{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:38:58Z","timestamp":1792795138031,"version":"4.5.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"12","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CAR"],"published-print":{"date-parts":[[2018,9,28]]},"abstract":"\n Background:<\/jats:title>\n Dysbiosis of intestinal microbiota in the elderly can cause a leaky gut, which\nmay result in silent systemic inflammation and promote neuroinflammation - a relevant pathomechanism\nin the early course of Alzheimer\u2019s disease.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n The rebalancing of the microbiome could benefically impact on gut inflammation and immune\nactivation.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In this study, routine laboratory tests in twenty outpatients (9 females, 11 males, aged 76.7 \u00b1\n9.6 years) with Alzheimer\u2019s disease were investigated. The mean Mini Mental State Examination score\nwas 18.5 \u00b1 7.7. Biomarkers of immune activation \u2013 serum neopterin and tryptophan breakdown - as\nwell as gut inflammation markers and microbiota composition in fecal specimens were analyzed in 18\npatients before and after probiotic supplementation for 4 weeks.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n After treatment a decline of fecal zonulin concentrations and an increase in Faecalibacterium\nprausnitzii compared to baseline were observed. At the same time, serum kynurenine concentrations\nincreased (p <0.05). Delta values (before - after) of neopterin and the kynurenine to tryptophan ratios\n(Kyn\/Trp) correlated significantly (p <0.05).<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Results show that the supplementation of Alzheimer\u2019s disease patients with a multispecies\nprobiotic influences gut bacteria composition as well as tryptophan metabolism in serum. The correlation\nbetween Kyn\/Trp and neopterin concentrations points to the activation of macrophages and\/or dendritic\ncells. Further studies are warranted to dissect the potential consequences of Probiotic supplementation\nin the course of Alzheimer\u2019s disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/1389200219666180813144834","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T05:20:13Z","timestamp":1535347213000},"page":"1106-1113","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":255,"title":["Probiotic Supplementation in Patients with Alzheimer\u2019s Dementia - An Explorative Intervention Study"],"prefix":"10.2174","volume":"15","author":[{"given":"Friedrich","family":"Leblhuber","sequence":"first","affiliation":[{"name":"Department of Gerontology, Neuromed Campus, Kepler University Clinic, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostja","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Neuromed Campus, Kepler University Clinic, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Schuetz","sequence":"additional","affiliation":[{"name":"Biovis Diagnostik MVZ GmbH, Limburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Division of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna M.","family":"Gostner","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Alzheimer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/164642","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/164642\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/164642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T11:01:43Z","timestamp":1609239703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/164642\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,28]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,9,28]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389200219666180813144834","relation":{},"ISSN":["1567-2050"],"issn-type":[{"value":"1567-2050","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9,28]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}