{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T05:14:14Z","timestamp":1721970854073},"reference-count":104,"publisher":"Bentham Science Publishers Ltd.","issue":"5","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDM"],"published-print":{"date-parts":[[2019,6,20]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> Vitamin D has an immunoregulatory action in Inflammatory Bowel Disease (IBD) as well\nas other immune-mediated disorders. Its influence on intestinal permeability, innate and adaptive immunity, and the\ncomposition and diversity of the microbiota contribute to the maintenance of intestinal homeostasis. Patients with\nIBD have a greater prevalence of vitamin D deficiency than the general population, and a possible association between\nthis deficit and a worse course of the disease. However, intervention studies in patients with IBD have proved\ninconclusive.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>To review all the evidence concerning the role of vitamin D as an important factor in the pathophysiology\nof IBD, review the associations found between its deficiency and the prognosis of the disease, and draw conclusions\nfor the practical application from the main intervention studies undertaken.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Method:<\/jats:title>\n<jats:p>Structured search and review of basic, epidemiological, clinical and intervention studies evaluating the\ninfluence of vitamin D in IBD, following the basic principles of scientific data.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Vitamin D deficiency is associated with disease activity, quality of life, the consumption of social and\nhealthcare resources, and the durability of anti-TNF\u03b1 biological treatment. Determination of new metabolites of\nvitamin D, measurement of its absorption capacity and questionnaires about sun exposure could help identify groups\nof IBD patients with a special risk of vitamin D deficiency.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Well-designed intervention studies are needed in IBD, with probably higher objective plasma doses of\nvitamin D to establish its efficacy as a therapeutic agent with immunomodulatory properties. Meanwhile, vitamin D\ndeficiency should be screened for and corrected in affected patients in order to achieve adequate bone and phosphocalcic\nmetabolism.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389200220666190520112003","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T23:47:52Z","timestamp":1558396072000},"page":"390-398","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Vitamin D in Inflammatory Bowel Disease: Biological, Clinical and Therapeutic  Aspects"],"prefix":"10.2174","volume":"20","author":[{"given":"Ra\u00fal Vicente","family":"Olmedo-Mart\u00edn","sequence":"first","affiliation":[{"name":"Clinical Management Unit of Digestive Diseases, Regional University Hospital of Malaga, Malaga, Spain; Faculty of Medicine, University of Malaga, Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Gonz\u00e1lez-Molero","sequence":"additional","affiliation":[{"name":"Clinical Management Unit of Endocrinology and Nutrition, Regional University Hospital of Malaga; Institute of Biomedical Research in Malaga (IBIMA), Malaga, Spain; Faculty of Medicine, University of Malaga; CIBERDEM, Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Olveira","sequence":"additional","affiliation":[{"name":"Clinical Management Unit of Endocrinology and Nutrition, Regional University Hospital of Malaga; Institute of Biomedical Research in Malaga (IBIMA), Malaga, Spain; Faculty of Medicine, University of Malaga; CIBERDEM, Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Amo-Trillo","sequence":"additional","affiliation":[{"name":"Clinical Management Unit of Digestive Diseases, Regional University Hospital of Malaga, Malaga, Spain; Faculty of Medicine, University of Malaga, Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Jim\u00e9nez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Clinical Management Unit of Digestive Diseases, Regional University Hospital of Malaga, Malaga, Spain; Faculty of Medicine, University of Malaga, Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000358131","volume":"32","author":"Dom\u00e8nech E.","year":"2014","unstructured":"Dom\u00e8nech E, Ma\u00f1osa M, Cabr\u00e9 E.  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