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However, traditional Body Surface Area (BSA)-based dosing\nis unsafe or ineffective, and a more accurate model-based approach is required.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>In this study, domestic swine were given 1 mg or 4 mg raltitrexed administered by an HAI with infusion\ntimes of 30, 60 and 120 min. Hepatic Artery (HA) and Peripheral Vein (PV) samples were collected, and a twocompartment\nmodel with an elimination pathway was established to describe the in vivo behavior of raltitrexed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> The clearance was 0.27 L\/min, and the volumes of distribution were 0.35 and 6.65 L for the HA and PV\ncompartments, respectively. The goodness-of-fit plots and visual predictive checks suggested that the proposed\npharmacokinetic model agreed well with the observations.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> The pharmacokinetic model could be helpful in quantitatively describing the detailed processes of raltitrexed\nactivity administered by HAI and determining an appropriate dosing regimen for preclinical and clinical\nstudies.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389200220666190618100847","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T03:21:59Z","timestamp":1561519319000},"page":"601-608","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hepatic Artery and Peripheral Vein Pharmacokinetics of Raltitrexed in Swine After the Administration of a Hepatic Arterial Infusion"],"prefix":"10.2174","volume":"20","author":[{"given":"Linzhong","family":"Zhu","sequence":"first","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Interventional Therapy, Peking University Cancer Hospital and Institute, Beijing 100142, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), National Drug Clinical Trial Center, Peking University Cancer Hospital and Institute, Beijing 100142, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Obstetrics and Gynecology Hospital, Beijing 100006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1016\/S0140-6736(02)08649-X","volume":"359","author":"Llovet J.M.","year":"2002","unstructured":"Llovet J.M.; Real M.I.; Monta\u00f1a X.; Planas R.; Coll S.; Aponte J.; Ayuso C.; Sala M.; Muchart J.; Sol\u00e0 R.; Rod\u00e9s J.; Bruix J.;  Arterial embolisation or chemoembolisation  versus  symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. 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