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In 50% of all acute liver failure\ncases, drug-induced hepatoxicity is the primary factor and 5% of all hospital admissions.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The various hepatotoxins used to induce hepatotoxicity in experimental animals include paracetamol, CCl4,\nisoniazid, thioacetamide, erythromycin, diclofenac, alcohol, etc. Among the various models used to induce hepatotoxicity\nin rats, every hepatotoxin causes toxicity by different mechanisms.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The drug-induced hepatotoxicity caused by paracetamol accounts for 39% of the cases and 13% hepatotoxicity\nis triggered by other hepatotoxic inducing agents.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Research carried out and the published papers revealed that hepatotoxins such as paracetamol and carbon-\ntetrachloride are widely used for experimental induction of hepatotoxicity in rats.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389200220666191105121653","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T09:30:50Z","timestamp":1573032650000},"page":"867-879","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Possible Pathways of Hepatotoxicity Caused by Chemical Agents"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5528-4907","authenticated-orcid":true,"given":"Roohi","family":"Mohi-ud-din","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Kashmir, Pharmacognosy Division, Hazratbal, Srinagar 190006, Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6825-1338","authenticated-orcid":true,"given":"Reyaz Hassan","family":"Mir","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar 190006, Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3003-9179","authenticated-orcid":true,"given":"Gifty","family":"Sawhney","sequence":"additional","affiliation":[{"name":"Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu-Tawi, Jammu 180001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Akbar","family":"Dar","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar 190006, Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulfiqar Ali","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Kashmir, Pharmacognosy Division, Hazratbal, Srinagar 190006, Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1056\/NEJMra052270","volume":"354","author":"Navarro V.J.","year":"2006","unstructured":"Navarro V.J.; Senior J.R.; Drug-related hepatotoxicity. 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