{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T07:46:16Z","timestamp":1773560776750,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDM"],"published-print":{"date-parts":[[2020,5,14]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Naphthalene ingestion and skin or inhalational exposure (accidental or deliberate) is an\nunder-recognized cause of a severe toxidrome in regions where it is commonly used (e.g., mothballs in households).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>This review is an update for the clinicians to understand the pharmacology, clinical features, laboratory\nevaluation, and treatment for naphthalene toxicity. High-quality literature for the past eight decades was collected\nand reviewed in this article. Several landmark articles were reviewed using PubMed, EMBASE Ovid, and the Cochrane\nLibrary, which have essential implications in the current toxicology practice.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results and Conclusion:<\/jats:title>\n<jats:p> Naphthalene toxicity usually occurs abruptly and leads to acute hemolysis, methemoglobinemia,\nrenal failure, respiratory depression, and acute brain dysfunction that are difficult to manage. The toxicity is\nmore marked in patients with G6PD deficiency and associated with high morbidity and mortality. The management\nshould mainly focus on high-quality supportive care; however, severe methemoglobinemia (&gt;20-30%) requires specific\ntherapy with intravenous methylene blue. Methylene blue is a highly effective agent but contraindicated in\nsevere G6PD deficiency.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389200220666191122110036","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T11:40:16Z","timestamp":1574422816000},"page":"63-66","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Naphthalene Toxicity in Clinical Practice"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-3478","authenticated-orcid":true,"given":"Ashok Kumar","family":"Pannu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5005-730X","authenticated-orcid":true,"given":"Vidhi","family":"Singla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Drug Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/176916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T16:50:07Z","timestamp":1589561407000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/176916\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,14]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,5,14]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389200220666191122110036","relation":{},"ISSN":["1389-2002"],"issn-type":[{"value":"1389-2002","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5,14]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}