{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T18:04:47Z","timestamp":1792865087060,"version":"4.5.0"},"reference-count":71,"publisher":"Bentham Science Publishers Ltd.","issue":"14","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDM"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Nanostructured lipid carriers (NLCs) are in high demand in the existing pharmaceutical\ndomain due to its high versatility. It is the newer generation of lipid nanoparticulate systems having a solid\nmatrix and greater stability at room temperature.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>To review the evidence related to the current state of the art of the NLCs system and its drug delivery\nperspectives to the brain.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Scientific data search, review of the current state of the art and drug delivery perspectives to the brain\nfor NLCs were undertaken to assess the applicability of NLCs in the management of neurological disorders\nthrough an intranasal route of drug administration<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>NLCs are designed to fulfill all the industrial needs like simple technology, low cost, scalability, and\nquantifications. Biodegradable and biocompatible lipids and surfactants used for NLCs have rendered them acceptable\nfrom regulatory perspectives as well. Apart from these, NLCs have unique properties of high drug payload,\nmodulation of drug release profile, minimum drug expulsion during storage, and incorporation in various\ndosage forms like gel, creams, granules, pellets, powders for reconstitution and colloidal dispersion. Ease of surface-\nmodification of NLCs enhances targeting efficiency and reduces systemic toxicity by providing site-specific\ndelivery to the brain through the intranasal route of drug administration.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The present review encompasses the in-depth discussion over the current state of the art of NLCs,\nnose-to-brain drug delivery perspectives, and its theranostic application as useful tools for better management\nof various neurological disorders. Further, pharmacokinetic consideration and toxicity concern is also discussed\nspecifically for the NLCs system exploited in nose-to-brain delivery.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389200221666200719003304","type":"journal-article","created":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T10:38:54Z","timestamp":1595155134000},"page":"1136-1143","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Nanostructured Lipid Carriers (NLCs): Nose-to-Brain Delivery and Theranostic Application"],"prefix":"10.2174","volume":"21","author":[{"given":"Javed","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, Najran University, Najran,Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Rizwanullah","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education &amp; Research, Jamia Hamdard, New Delhi-110062,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education &amp; Research, Jamia Hamdard, New Delhi-110062,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musarrat Husain","family":"Warsi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif-Al-Haweiah 21974,Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Zaki","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, Najran University, Najran,Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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