{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:39:47Z","timestamp":1759963187072,"version":"3.37.3"},"reference-count":60,"publisher":"Bentham Science Publishers Ltd.","issue":"3","funder":[{"DOI":"10.13039\/501100013076","name":"National Major Scientific and Technological Special Project","doi-asserted-by":"publisher","award":["2018ZX09735006"],"award-info":[{"award-number":["2018ZX09735006"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703665","81773874","81973476","81903807"],"award-info":[{"award-number":["81703665","81773874","81973476","81903807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDM"],"published-print":{"date-parts":[[2021,4,21]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> The roots of Polygonum multiflorum (PM) are a well-known traditional Chinese\nmedicine, widely used to treat a variety of conditions in Southeast Asia, South Korea, Japan and other countries.\nIt is known that Polygoni Multiflori Radix Praeparata (PMRP) may enhance the efficacy and reduce the\ntoxicity of PM. However, reports of adverse reactions, such as hepatotoxicity, caused by PM or PMRP, have\ncontinuously appeared around the world, which increased the known risks of the medication and gradually\ngained the extensive attention of many researchers. The chemical constituents of PM that cause hepatotoxicity\nhave not been distinctly elucidated using the traditional phytochemical screening. Recently, with the rapid development\nof metabolomics, there has been a growing need to explore the potential hepatotoxic components\nand mechanisms of PM.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The metabolites and metabolomics of PM were searched by the Web of Science, PubMed, Google\nscholar and some Chinese literature databases.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>A brief description of metabolites and metabolomics of PM is followed by a discussion on the metabolite-\ninduced toxicity in this review. More than 100 metabolites were tentatively identified and this will contribute\nto further understanding of the potential hepatotoxic components of PM. Meanwhile, some toxic compounds\nwere identified and could be used as potential toxic markers of PM.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>This review mainly outlines the metabolites and metabolomics of PM that have been identified in\nrecent years. This study could help to clarify the potential hepatotoxic components and metabolic mechanisms\nof PM and provide a scientific reference for its safe clinical use in the future.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389200221666201201091345","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T04:07:31Z","timestamp":1606882051000},"page":"165-172","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Advances in Understanding the Metabolites and Metabolomics of Polygonum multiflorum Thunb: A Mini-review"],"prefix":"10.2174","volume":"22","author":[{"given":"Jian-Bo","family":"Yang","sequence":"first","affiliation":[{"name":"Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Yu","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Fei","family":"Song","sequence":"additional","affiliation":[{"name":"Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang-Cheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-Long","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, National Institutes for Food and Drug Control, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"journal-title":"Pharmacopoeia of the People\u2019s Republic of China","year":"2015","key":"ref=1","unstructured":"Pharmacopoeia of the People\u2019s Republic of China Chinese Pharmacopoeia Commission2015"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jep.2014.11.009","volume":"159","author":"Lin L.","year":"2015","unstructured":"Lin L.; Ni B.; Lin H.; Zhang M.; Li X.; Yin X.; Qu C.; Ni J.; Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review. J Ethnopharmacol 2015,159,158-183","journal-title":"J Ethnopharmacol"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1002\/jssc.201600913","volume":"40","author":"Yu X.A.","year":"2017","unstructured":"Yu X.A.; Ge A.H.; Zhang L.; Li J.; An M.; Cao J.; He J.; Gao X.M.; Chang Y.X.; Influence of different processing times on the quality of Polygoni multiflora Radix by metabolomics based on ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry. J Sep Sci 2017,40(9),1928-1941","journal-title":"J Sep Sci"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ctim.2013.12.008","volume":"22","author":"Dong H.","year":"2014","unstructured":"Dong H.; Slain D.; Cheng J.; Ma W.; Liang W.; Eighteen cases of liver injury following ingestion of Polygonum multiflorum. Complement Ther Med 2014,22(1),70-74","journal-title":"Complement Ther Med"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"459749","DOI":"10.1155\/2015\/459749","volume":"2015","author":"Lei X.","year":"2015","unstructured":"Lei X.; Chen J.; Ren J.; Li Y.; Zhai J.; Mu W.; Zhang L.; Zheng W.; Tian G.; Shang H.; Liver damage associated with Polygonum multiflorum Thunb.; a systematic review of case reports and case series. Evid Based Complement Alternat Med 2015,2015,459749","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3389\/fphar.2017.00349","volume":"8","author":"Lin L.","year":"2017","unstructured":"Lin L.; Li H.; Lin H.; Zhang M.; Qu C.; Yan L.; Yin X.; Ni J.; A new perspective on liver injury by traditional chinese herbs such as Polygonum multiflorum: the geographical area of harvest as an important contributory factor. Front Pharmacol 2017,8,349","journal-title":"Front Pharmacol"},{"key":"ref=7","first-page":"382","volume":"15","author":"Niu X.P.","year":"1996","unstructured":"Niu X.P.; A severe liver damage case induced by Shou Wu Pian though oral administration. Chinese J New Drugs Clin Rem 1996,15,382-386","journal-title":"Chinese J New Drugs Clin Rem"},{"key":"ref=8","first-page":"280","volume":"38","author":"But P.P.","year":"1996","unstructured":"But P.P.; Tomlinson B.; Lee K.L.; Hepatitis related to the Chinese medicine Shou-wu-pian manufactured from Polygonum multiflorum. Vet Hum Toxicol 1996,38(4),280-282","journal-title":"Vet Hum Toxicol"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1046\/j.1440-1746.2001.02309.x","volume":"16","author":"Park G.J.","year":"2001","unstructured":"Park G.J.; Mann S.P.; Ngu M.C.; Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum. J Gastroenterol Hepatol 2001,16(1),115-117","journal-title":"J Gastroenterol Hepatol"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"W30","DOI":"10.7326\/0003-4819-140-7-200404060-00042-w3","volume":"140","author":"Mazzanti G.","year":"2004","unstructured":"Mazzanti G.; Battinelli L.; Daniele C.; Mastroianni C.M.; Lichtner M.; Coletta S.; Costantini S.; New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum multiflorum. Ann Intern Med 2004,140(7),W30","journal-title":"Ann Intern Med"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1097\/MCG.0b013e3181492515","volume":"42","author":"Laird A.R.","year":"2008","unstructured":"Laird A.R.; Ramchandani N.; deGoma E.M.; Avula B.; Khan I.A.; Gesundheit N.; Acute hepatitis associated with the use of an herbal supplement (Polygonum multiflorum) mimicking iron-overload syndrome. J Clin Gastroenterol 2008,42(7),861-862","journal-title":"J Clin Gastroenterol"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1248\/jhs.55.720","volume":"55","author":"Noda T.","year":"2009","unstructured":"Noda T.; Yamada T.; Ohkubo T.; Omura T.; Ono T.; Adachi T.; Awaya T.; Tasaki Y.; Shimizu K.; Matsubara K.; Hot-water-extracts of Polygonum multiflorum do not induce any toxicity but elicit limited beneficial effects on the liver in Mice. J Health Sci 2009,55(5),720-725","journal-title":"J Health Sci"},{"key":"ref=13","first-page":"S25","volume":"14","author":"Wang Z.Z.","year":"2014","unstructured":"Wang Z.Z.; Potential liver damage induced by Polygonum multiflorum and its set prescription preparation. Yaoxue Fuwu Yu Yanjiu 2014,14(6),S25-S26","journal-title":"Yaoxue Fuwu Yu Yanjiu"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.4103\/0974-8490.157957","volume":"7","author":"Bounda G.A.","year":"2015","unstructured":"Bounda G.A.; Feng Y.U.; Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds. Pharmacognosy Res 2015,7(3),225-236","journal-title":"Pharmacognosy Res"},{"key":"ref=15","first-page":"459749","author":"Lei X.","year":"2015","unstructured":"Lei X.; Chen J.; Li Y.; Zhai J.B.; Zheng W.K.; Ren J.T.; Mu W.; Zhang L.; Tian G.H.; Shang H.C.; Liver damage associated with Polygonum multiflorum Thunb.: A systematic review of case reports and case series. Evid-Based Complementary Altern Med 2015,459749","journal-title":"Evid-Based Complementary Altern Med"},{"key":"ref=16","first-page":"192","volume":"25","author":"Wang H.","year":"2019","unstructured":"Wang H.; Yang J.; Zhou L.Y.; Lou B.; Cheng X.X.; Zhang C.R.; Tang X.M.; Pan L.M.; Liu L.; Yang Q.; Chemical compositions and pharmacological activities of Polygoni multiflori Radix. Chin J Exp Tradit Med Form 2019,25(13),192-205","journal-title":"Chin J Exp Tradit Med Form"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1080\/10286020.2016.1171758","volume":"18","author":"Yang J.B.","year":"2016","unstructured":"Yang J.B.; Li L.; Dai Z.; Wu Y.; Geng X.C.; Li B.; Ma S.C.; Wang A.G.; Su Y.L.; Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb. J Asian Nat Prod Res 2016,18(9),813-822","journal-title":"J Asian Nat Prod Res"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.fitote.2016.11.009","volume":"117","author":"Yang J.B.","year":"2017","unstructured":"Yang J.B.; Tian J.Y.; Dai Z.; Ye F.; Ma S.C.; Wang A.G.; a-Glucosidase inhibitors extracted from the roots of Polygonum multiflorum Thunb. Fitoterapia 2017,117,65-70","journal-title":"Fitoterapia"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s12272-016-0816-7","volume":"41","author":"Yang J.","year":"2018","unstructured":"Yang J.; Yan Z.; Ren J.; Dai Z.; Ma S.; Wang A.; Su Y.; Polygonumnolides A1-B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb. Arch Pharm Res 2018,41(6),617-624","journal-title":"Arch Pharm Res"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jpba.2019.03.049","volume":"172","author":"Yang J.B.","year":"2019","unstructured":"Yang J.B.; Liu Y.; Wang Q.; Ma S.C.; Wang A.G.; Cheng X.L.; Wei F.; Characterization and identification of the chemical constituents of Polygonum multiflorum Thunb. by high-performance liquid chromatography coupled with ultraviolet detection and linear ion trap FT-ICR hybrid mass spectrometry. J Pharm Biomed Anal 2019,172,149-166","journal-title":"J Pharm Biomed Anal"},{"key":"ref=21","first-page":"744","volume":"30","author":"Quan Y.Y.","year":"2018","unstructured":"Quan Y.Y.; Zhou Y.M.; Liu M.C.; Li Y.X.; Hepatotoxicity evaluation of eighteen compounds in Polygoni multiflora with zebrafish (Danio rerio) model. Nat Prod Res Dev 2018,30,744-752","journal-title":"Nat Prod Res Dev"},{"key":"ref=22","first-page":"694","volume":"35","author":"Song Q.","year":"2016","unstructured":"Song Q.; Ma Z.J.; Wang J.B.; Xiao X.H.; Zhao K.J.; Study on the effect of Polygonum multiflorum and its main components against L02 cells. Beijing J Tradit Chin Med 2016,35(7),694-697","journal-title":"Beijing J Tradit Chin Med"},{"key":"ref=23","first-page":"1041","volume":"52","author":"Zhang L.","year":"2017","unstructured":"Zhang L.; Bai Z.F.; Li C.Y.; Huhuang W.Y.; Sha M.C.; Liu Z.X.; He Q.; Li Y.M.; Liu Y.P.; Xiao X.H.; Wang J.B.; Study on idiosyncratic liver injury and content of cis-2,3,5,4\u2032-tetrahydroxystilbene-2-O-\u03b2-D-glucoside in radix Polygoni multiflori Preparata. Yao Xue Xue Bao 2017,52(7),1041-1047","journal-title":"Yao Xue Xue Bao"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.biopha.2018.01.033","volume":"99","author":"Yang J.B.","year":"2018","unstructured":"Yang J.B.; Li W.F.; Liu Y.; Wang Q.; Cheng X.L.; Wei F.; Wang A.G.; Jin H.T.; Ma S.C.; Acute toxicity screening of different extractions, components and constituents of Polygonum multiflorum Thunb. on zebrafish (Danio rerio) embryos in vivo. Biomed Pharmacother 2018,99,205-213","journal-title":"Biomed Pharmacother"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.tig.2008.10.010","volume":"25","author":"Fernie A.R.","year":"2009","unstructured":"Fernie A.R.; Schauer N.; Metabolomics-assisted breeding: a viable option for crop improvement? Trends Genet 2009,25(1),39-48","journal-title":"Trends Genet"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"6429","DOI":"10.1021\/ac300829f","volume":"84","author":"Roux A.","year":"2012","unstructured":"Roux A.; Xu Y.; Heilier J.F.; Olivier M.F.; Ezan E.; Tabet J.C.; Junot C.; Annotation of the human adult urinary metabolome and metabolite identification using ultra high performance liquid chromatography coupled to a linear quadrupole ion trap-orbitrap mass spectrometer. Anal Chem 2012,84(15),6429-6437","journal-title":"Anal Chem"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.trac.2013.08.003","volume":"52","author":"Armitage E.G.","year":"2013","unstructured":"Armitage E.G.; Rup\u00e9rez F.J.; Barbas C.; Metabolomics of dietrelated diseases using mass spectrometry. Trac Trends Analyt Chem 2013,52,61-73","journal-title":"Trac Trends Analyt Chem"},{"key":"ref=28","first-page":"351","volume":"34","author":"Gan H.","year":"2007","unstructured":"Gan H.; Dou G.F.; Advances in research on the reactive metabolites. Int J Pharm Res 2007,34(5),351-355","journal-title":"Int J Pharm Res"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.2174\/1389200221666200103090757","volume":"20","author":"Rathaur P.","year":"2019","unstructured":"Rathaur P.; S R J.K.; Metabolism and pharmacokinetics of phytochemicals in the human body. Curr Drug Metab 2019,20(14),1085-1102","journal-title":"Curr Drug Metab"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S1089-3261(05)70097-0","volume":"4","author":"Zimmerman H.J.","year":"2000","unstructured":"Zimmerman H.J.; Drug-induced liver disease. Clin Liver Dis 2000,4(1),73-96, vi","journal-title":"Clin Liver Dis"},{"key":"ref=31","first-page":"0357","volume":"16","author":"Huang J.","year":"2018","unstructured":"Huang J.; Zhang J.P.; Bai J.Q.; Wei M.J.; Zhang J.; Huang Z.H.; Qu G.H.; Xu W.; Qiu X.H.; Chemical profiles and metabolite study of raw and processed Polygoni multiflori Radix in rats by UPLC-LTQ-orbitrap MSn spectrometry. Chin J Nat Med 2018,16(5),0357-0400","journal-title":"Chin J Nat Med"},{"key":"ref=32","first-page":"2796","volume":"43","author":"Guo Z.H.","year":"2018","unstructured":"Guo Z.H.; Jia Z.X.; Chen K.K.; Liu J.; Xu W.J.; Duan F.P.; Xian Z.; Wei Z.Y.; Chen L.M.; Xiao H.B.; [Studies on constituents of Polygonum multiflorum extract in vivo and in vitro based on UPLC-Q-TOF-MS]. Zhongguo Zhongyao Zazhi 2018,43(13),2796-2805","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1002\/bmc.3456","volume":"29","author":"Lin L.","year":"2015","unstructured":"Lin L.; Lin H.; Yin X.; Zhao Y.; Xia Z.; Zhang M.; Li X.; Han J.; Qu C.; Ni J.; Characterization of the constituents in rat plasma after oral administration of radix Polygoni multiflori extracts by ultra-performance liquid chromatography\/quadrupole time-of-flight mass spectrometry. Biomed Chromatogr 2015,29(10),1541-1547","journal-title":"Biomed Chromatogr"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3389\/fphar.2019.00329","volume":"10","author":"Han L.","year":"2019","unstructured":"Han L.; Wang P.; Wang Y.; Zhao Q.; Zheng F.; Dou Z.; Yang W.; Hu L.; Liu C.; Rapid discovery of the potential toxic compounds in Polygonum multiflorum by UHPLC\/Q-orbitrap-MS-based metabolomics and correlation analysis. Front Pharmacol 2019,10,329","journal-title":"Front Pharmacol"},{"key":"ref=35","first-page":"1048","volume":"50","author":"Lin P.","year":"2015","unstructured":"Lin P.; Lu J.M.; Zhang G.Y.; Li Y.F.; Geng C.A.; Chen J.J.; Yue J.; Zhao R.H.; Study on absorption and metabolism of active compounds of Polygoni multiflori Radix in hepatic l-02 cells by liquid chromatography tandem-mass spectrometry. Chung Kuo Yao Hsueh Tsa Chih 2015,50(12),1048-1053","journal-title":"Chung Kuo Yao Hsueh Tsa Chih"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1021\/acs.chemrestox.8b00026","volume":"31","author":"Qin X.","year":"2018","unstructured":"Qin X.; Peng Y.; Zheng J.; \n                        In vitro and in vivo studies of the electrophilicity of physcion and its oxidative metabolites. Chem Res Toxicol 2018,31(5),340-349","journal-title":"Chem Res Toxicol"},{"key":"ref=37","first-page":"329","volume":"38","author":"Pei Y.H.","year":"2011","unstructured":"Pei Y.H.; Wu H.H.; Chen G.; Application of metabolomics in hepatotoxicity and nephrotoxicity evaluation of natural medicines. J Int Pharm Res 2011,38(5),329-335","journal-title":"J Int Pharm Res"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jchromb.2008.04.031","volume":"871","author":"Lu W.","year":"2008","unstructured":"Lu W.; Bennett B.D.; Rabinowitz J.D.; Analytical strategies for LC-MS-based targeted metabolomics. J Chromatogr B Analyt Technol Biomed Life Sci 2008,871(2),236-242","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref=39","first-page":"934\/1","volume":"9","author":"Liang L.","year":"2018","unstructured":"Liang L.; Xu J.; Zhou W.W.; Brand E.; Chen H.B.; Zhao Z.Z.; Integrating targeted and untargeted metabolomics to investigate the processing chemistry of Polygoni multiflori radix. Front Pharmacol 2018,9,934\/1-934\/19","journal-title":"Front Pharmacol"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3389\/fphar.2015.00217","volume":"6","author":"Dong Q.","year":"2015","unstructured":"Dong Q.; Li N.; Li Q.; Zhang C.E.; Feng W.W.; Li G.Q.; Li R.Y.; Tu C.; Han X.; Bai Z.F.; Zhang Y.M.; Niu M.; Ma Z.J.; Xiao X.H.; Wang J.B.; Screening for biomarkers of liver injury induced by Polygonum multiflorum: a targeted metabolomic study. Front Pharmacol 2015,6,217","journal-title":"Front Pharmacol"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1177\/0192623309332992","volume":"37","author":"Boudonck K.J.","year":"2009","unstructured":"Boudonck K.J.; Mitchell M.W.; N\u00e9met L.; Keresztes L.; Nyska A.; Shinar D.; Rosenstock M.; Discovery of metabolomics biomarkers for early detection of nephrotoxicity. Toxicol Pathol 2009,37(3),280-292","journal-title":"Toxicol Pathol"},{"key":"ref=42","first-page":"10986","volume":"8","author":"Zhang Y.","year":"2015","unstructured":"Zhang Y.; Wang N.; Zhang M.; Diao T.; Tang J.; Dai M.; Chen S.; Lin G.; Metabonomics study on Polygonum multiflorum induced liver toxicity in rats by GC-MS. Int J Clin Exp Med 2015,8(7),10986-10992","journal-title":"Int J Clin Exp Med"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jep.2017.03.046","volume":"203","author":"Xia X.H.","year":"2017","unstructured":"Xia X.H.; Yuan Y.Y.; Liu M.; The assessment of the chronic hepatotoxicity induced by Polygoni multiflori Radix in rats: a pilot study by using untargeted metabolomics method. J Ethnopharmacol 2017,203,182-190","journal-title":"J Ethnopharmacol"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.jep.2016.09.011","volume":"194","author":"Zhang C.E.","year":"2016","unstructured":"Zhang C.E.; Niu M.; Li Q.; Zhao Y.L.; Ma Z.J.; Xiong Y.; Dong X.P.; Li R.Y.; Feng W.W.; Dong Q.; Ma X.; Zhu Y.; Zou Z.S.; Cao J.L.; Wang J.B.; Xiao X.H.; Urine metabolomics study on the liver injury in rats induced by raw and processed Polygonum multiflorum integrated with pattern recognition and pathways analysis. J Ethnopharmacol 2016,194,299-306","journal-title":"J Ethnopharmacol"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13020-019-0268-3","volume":"14","author":"Zhang Z.","year":"2019","unstructured":"Zhang Z.; Yang L.; Huang X.; Gao Y.; Metabolomics profiling of Polygoni multiflori Radix and Polygoni multiflori Radix Preparata extracts using UPLC-Q\/TOF-MS. Chin Med 2019,14,46","journal-title":"Chin Med"},{"key":"ref=46","first-page":"152","volume":"42","author":"Ma Z.J.","year":"2017","unstructured":"Ma Z.J.; Li Q.; Zhao K.J.; Wang J.B.; Xiao X.H.; [Dynamic serum metabolomics study of liver injury in rats caused by Polygonum multifulorum]. Zhongguo Zhongyao Zazhi 2017,42(1),152-156","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3389\/fphar.2016.00483","volume":"7","author":"Li C.Y.","year":"2016","unstructured":"Li C.Y.; Tu C.; Gao D.; Wang R.L.; Zhang H.Z.; Niu M.; Li R.Y.; Zhang C.E.; Li R.S.; Xiao X.H.; Yang M.H.; Wang J.B.; Metabolomic study on idiosyncratic liver injury induced by different extracts of Polygonum multiflorum in rats integrated with pattern recognition and enriched pathways analysis. Front Pharmacol 2016,7,483","journal-title":"Front Pharmacol"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3389\/fphar.2018.00364","volume":"9","author":"Liu Y.","year":"2018","unstructured":"Liu Y.; Wang, Qi.; Yang, J.B.; Guo, X.X.; Liu, W.X.; Ma, S.C.; Li, S.P. Polygonum multiflorum Thunb.: A review on chemical analysis, processingn mechanism, quality evaluation, and hepatotoxicity. Front Pharmacol 2018,9,364","journal-title":"Front Pharmacol"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"493","DOI":"10.5009\/gnl.2011.5.4.493","volume":"5","author":"Jung K.A.","year":"2011","unstructured":"Jung K.A.; Min H.J.; Yoo S.S.; Kim H.J.; Choi S.N.; Ha C.Y.; Kim H.J.; Kim T.H.; Jung W.T.; Lee O.J.; Lee J.S.; Shim S.G.; Gut and and liver, drug-induced liver injury: twenty five cases of acute hepatitis following ingestion of Polygonum multiflorum Thunb. Gut Liver 2011,5(4),493-499","journal-title":"Gut Liver"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"17952","DOI":"10.1038\/s41598-017-18231-y","volume":"7","author":"Wang Q.","year":"2017","unstructured":"Wang Q.; Wang Y.; Li Y.; Wen B.; Dai Z.; Ma S.; Zhang Y.; Identification and characterization of the structure-activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum. Sci Rep 2017,7(1),17952","journal-title":"Sci Rep"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1039\/C4TX00246F","volume":"4","author":"Liu X.Y.","year":"2015","unstructured":"Liu X.Y.; Liu Y.Q.; Qu Y.; Cheng M.C.; Xiao H.B.; Metabolomic profiling of emodin-induced cytotoxicity in human liver cells and mechanistic study. Toxicol Res 2015,4(4),948-955","journal-title":"Toxicol Res"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s11684-017-0508-9","volume":"11","author":"Li C.","year":"2017","unstructured":"Li C.; Niu M.; Bai Z.; Zhang C.; Zhao Y.; Li R.; Tu C.; Li H.; Jing J.; Meng Y.; Ma Z.; Feng W.; Tang J.; Zhu Y.; Li J.; Shang X.; Zou Z.; Xiao X.; Wang J.; Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum. Front Med 2017,11(2),253-265","journal-title":"Front Med"},{"key":"ref=53","first-page":"379","volume":"43","author":"Meng Z.J.","year":"2019","unstructured":"Meng Z.J.; Ding X.S.; Recent advances in the study of Polygoni multiflori Radix: its absorbed components in rat blood, pharmacokinetics and metabolomic study of hepatotoxicity. Prog Pharm Sci 2019,43(5),379-383","journal-title":"Prog Pharm Sci"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00204-019-02595-3","volume":"94","author":"Zhang L.","year":"2020","unstructured":"Zhang L.; Niu M.; Wei A.W.; Tang J.F.; Tu C.; Bai Z.F.; Zou Z.S.; Xiao X.H.; Liu Y.P.; Wang J.B.; Risk profiling using metabolomic characteristics for susceptible individuals of drug-induced liver injury caused by Polygonum multiflorum. Arch Toxicol 2020,94(1),245-256","journal-title":"Arch Toxicol"},{"key":"ref=55","first-page":"1069","volume":"52","author":"Li C.Y.","year":"2017","unstructured":"Li C.Y.; Qin H.; Tang J.F.; Sha M.C.; Tu C.; Zhang L.; Liu Z.X.; Wang J.B.; Xiao X.H.; Metabolomic study on immunological stress-mediated hepatotoxicity of Polygonum multiflorum and its processed products of nine times steaming and nine times sunning. Yao Xue Xue Bao 2017,52(7),1069-1076","journal-title":"Yao Xue Xue Bao"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"791","DOI":"10.3389\/fphar.2017.00791","volume":"8","author":"Li Y.X.","year":"2017","unstructured":"Li Y.X.; Gong X.H.; Liu M.C.; Peng C.; Li P.; Wang Y.T.; Investigation of liver injury of Polygonum multiflorum Thunb. in rats by metabolomics and traditional approaches. Front Pharmacol 2017,8,791","journal-title":"Front Pharmacol"},{"key":"ref=57","first-page":"620","volume":"35","author":"Jiao C.L.","year":"2018","unstructured":"Jiao C.L.; Ou L.; Gao F.; Yu J.H.; Miao F.; Wang L.P.; Wei P.F.; Meng D.L.; Plasma metabolomics study on liver injury in kidney-yang deficiency syndrome rats induced by raw and processed Polygonum multiflorum. J Shenyang Pharm Univ 2018,35(8),620-627","journal-title":"J Shenyang Pharm Univ"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"10489","DOI":"10.1021\/acsomega.0c00647","volume":"5","author":"Yan Y.","year":"2020","unstructured":"Yan Y.; Shi N.; Han X.; Li G.; Wen B.; Gao J.; UPLC\/MS\/MS-based metabolomics study of the hepatotoxicity and nephrotoxicity in rats induced by Polygonum multiflorum Thunb. ACS Omega 2020,5(18),10489-10500","journal-title":"ACS Omega"},{"key":"ref=59","first-page":"128","volume":"28","author":"Zhang L.","year":"2019","unstructured":"Zhang L.; Wang L.Y.; Zhang K.X.; Wei G.H.; Yang Z.G.; Metabolomics databases for natural products research and development. Chem Anal Meter 2019,28,128-134","journal-title":"Chem Anal Meter"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s13765-013-3075-z","volume":"56","author":"Jiang X.","year":"2013","unstructured":"Jiang X.; Oh I.H.; Lee S.G.; Choi H.K.; The application of metabolomics to processed traditional Chinese medicine. J Korean Soc Appl Biol Chem 2013,56,475-481","journal-title":"J Korean Soc Appl Biol Chem"}],"container-title":["Current Drug Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/188535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/188535\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/188535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T16:48:55Z","timestamp":1632502135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/188535\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,4,21]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389200221666201201091345","relation":{},"ISSN":["1389-2002"],"issn-type":[{"type":"print","value":"1389-2002"}],"subject":[],"published":{"date-parts":[[2021,4,21]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}