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More than ten types of compounds-such as flavonoids, caffeinate esters, and volatile oils-have been identified in Erigeron breviscapus; however, it remains unknown as to which compounds are associated with clinical efficacy. In recent years, flavonoids and phenolic acids have been considered as the main effective components of Erigeron breviscapus. The metabolism and mechanisms of these compounds in vivo have been extensively studied to improve our understanding of the drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>In the present review, we summarize the relationships among these compounds, their metabolites, and their pharmacodynamics. Many methods have been implemented to improve the separation and bioavailability of these compounds from Erigeron breviscapus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>In China, Erigeron breviscapus has been used for many years. In recent years, through the study of its metabolism and the mechanisms of its effective components, the effects of Erigeron breviscapus in the treatment of various diseases have been extensively studied. Findings have indicated that Erigeron breviscapus improves cardiovascular and cerebrovascular function and that one of its ingredients, scutellarin, has potential value in the treatment of Alzheimer's disease, cancer, diabetic vascular complications, and other conditions. In addition, phenolic acid compounds and their metabolites also play an important role in anti-oxidation, anti-inflammation, and improving blood lipids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Erigeron breviscapus plays an important role in the prevention and treatment of cardiovascular\/ cerebrovascular diseases, neuroprotection, and cancer through many different mechanisms of action. Further investigation of its efficacious components and metabolites may provide more possibilities for the clinical application of traditional Chinese medicine and the development of novel drugs.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1389200221666201217093255","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T07:26:13Z","timestamp":1608276373000},"page":"24-39","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Metabolism and Pharmacological Mechanisms of Active Ingredients in Erigeron breviscapus"],"prefix":"10.2174","volume":"22","author":[{"given":"Hua","family":"Fan","sequence":"first","affiliation":[{"name":"Liaoning Inspection, Examination & Certification Centre, Shenyang110036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lin","sequence":"additional","affiliation":[{"name":"Liaoning Inspection, Examination & Certification Centre, Shenyang110036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Kang","sequence":"additional","affiliation":[{"name":"Liaoning Inspection, Examination & Certification Centre, Shenyang110036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Long","family":"Zhao","sequence":"additional","affiliation":[{"name":"Liaoning Inspection, Examination & Certification Centre, Shenyang110036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Wang","sequence":"additional","affiliation":[{"name":"Liaoning Inspection, Examination & Certification Centre, Shenyang110036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Liaoning University of Traditional Chinese Medicine, Shenyang110847, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"393","volume":"41","author":"Guo X.","year":"2009","unstructured":"Guo X.; Lin S.; Wu L.M.; Tian X.H.; Progress in the study of chemical constituents and pharmacological effects of Erigeron breviscapus. 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