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This multifaceted chemical entity has become a point of focus during recent years due to its\nnumerous pharmacological applications, e.g., anticancer, anti-inflammatory, antiviral, antioxidant, anti-adipogenic,\nanti-androgenic, antimicrobial, insecticidal, and neuroprotective. Germacrone is an effective inducer of cell cycle\narrest and apoptosis in various cancers (breast, brain, liver, skin, prostate, gastric, and esophageal) via modulation of\ndifferent cell signaling molecules and pathways involved in cancer proliferation. This is the first report highlighting\nthe wide spectrum of pharmacological activities exhibited by germacrone. The reported data collected from various\nshreds of evidences recommend that this multifaceted compound could serve as a potential drug candidate in the near\nfuture.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1389200221999200728144801","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T02:37:47Z","timestamp":1595990267000},"page":"1079-1090","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections"],"prefix":"10.2174","volume":"21","author":[{"given":"Ammara","family":"Riaz","sequence":"first","affiliation":[{"name":"Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000,Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhar","family":"Rasul","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000,Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazia","family":"Kanwal","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000,Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000,Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3471-184X","authenticated-orcid":true,"given":"Muhammad Ajmal","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000,Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqra","family":"Sarfraz","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000,Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubab","family":"Ishfaq","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000,Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Batool","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000,Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariha","family":"Rukhsar","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000,Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eevki","family":"Adem","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, \u00c7ank\u0131r\u0131 Karatekin \u00dcniversitesi \u00c7ank\u0131r\u0131, 18100,Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mam.2005.07.008","volume":"27","author":"Gurib-Fakim A.","year":"2006","unstructured":"Gurib-Fakim A.; Medicinal plants: traditions of yesterday and drugs of tomorrow. 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