{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:22:45Z","timestamp":1747207365758,"version":"3.40.5"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"9","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDM"],"published-print":{"date-parts":[[2020,12,14]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Chronic respiratory diseases (CRDs) are increasing in prevalence, as reported by the\nWorld Health Organization (WHO). Patients with CRDs usually require co-administration of multiple drugs\ndue to the complex pathogenic mechanisms of CRDs and the existence of concomitant diseases. Polypharmacy\n(co-administration of more than four medications) is the main risk factor of the occurrence of drug-drug interactions\n(DDIs) that may lead to reducing treatment efficacy and\/or increasing adverse effects.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>This literature-based review focuses on metabolism-based DDIs, the most prevalent DDIs responsible\nfor difficulties in therapeutic management in patients with CRDs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Clinically relevant metabolism-based DDIs occur between drugs used for the treatment of respiratory\ndiseases (corticosteroids, orally inhaled bronchodilators, methylxanthines, anti-leukotrienes, antimicrobials, endothelin\nreceptor antagonists, phosphodiesterase inhibitors, antitussives, and antineoplastic agents) and drugs affecting\ncytochrome P450 (CYP) (inducers and inhibitors). Considering alternative therapies, adjusting medication\ndoses, or monitoring patients during treatment are recommended to prevent the harmful consequences of\nthese interactions.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Providing information on clinically relevant interactions of drugs more likely prescribed in daily\npractices of physicians is essential to improve patient safety. A list of known metabolism-based interactions of\ndrugs affecting the respiratory systems should be available for physicians engaged in the treatment of CRDs.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389200221999200820164038","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T04:16:12Z","timestamp":1608005772000},"page":"704-713","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolism-based Drug-drug Interactions in Patients with Chronic Respiratory Diseases: A Review Focusing on Drugs Affecting the Respiratory System"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3918-0104","authenticated-orcid":true,"given":"Shadi","family":"Baniasadi","sequence":"first","affiliation":[{"name":"Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Drug Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/185181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/185181\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/185181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T13:40:06Z","timestamp":1608385206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/185181\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,14]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,12,14]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389200221999200820164038","relation":{},"ISSN":["1389-2002"],"issn-type":[{"type":"print","value":"1389-2002"}],"subject":[],"published":{"date-parts":[[2020,12,14]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}