{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:45:29Z","timestamp":1773103529996,"version":"3.50.1"},"reference-count":124,"publisher":"Bentham Science Publishers Ltd.","issue":"3","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670851"],"award-info":[{"award-number":["31670851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1306605"],"award-info":[{"award-number":["2016YFC1306605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDM"],"published-print":{"date-parts":[[2021,4,21]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Neuropathic pain (NP) is an egregious problem worldwide. Due to the side-effects of\noral drugs, drugs delivered directly to the affected area of pain are preferred.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Capsaicin, a chemical compound isolated from chili peppers, is used as an analgesic in topical ointments\nand dermal patches to alleviate pain. Objective of the study is to review the application and functionality\nof topical capsaicin in treatment of neuropathic pain.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Data sources:<\/jats:title>\n<jats:p>To systematically review capsaicin\u2019s functions on NP, we retrieved articles from the PubMed\ndatabase published in the last ten years.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Study eligibility criteria:<\/jats:title>\n<jats:p>The inclusion criteria were capsaicin and the use of capsaicin for the treatment of NP;\non the other hand, articles were excluded according to the mentioned criteria such as abstracts, articles written\nin any language other than English, incomplete articles, and conference papers.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Participants and interventions:<\/jats:title>\n<jats:p>Out of 265 articles, 108 articles were selected after filtering through the inclusion\nand exclusion criteria. The data and knowledge currently existing for capsaicin treatment in NP are summarized.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>This review indicates that capsaicin effectively improves NP treatment without affecting the motor\nand large nerve fibres involved in sensory function. Transient receptor potential channel vanilloid type 1 (TRPV1)\nis the capsaicin receptor expressed in central and peripheral terminals of a sensitive primary nerve cell.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions and implications of key findings:<\/jats:title>\n<jats:p>Topical capsaicin has a sensible safety profile and is effective\nin reducing NP. Therefore, studies over the last decade suggest that capsaicin might be a potential drug for NP\ntreatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389200221999201116143701","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:00:23Z","timestamp":1605600023000},"page":"198-207","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Topical Capsaicin for the Treatment of Neuropathic Pain"],"prefix":"10.2174","volume":"22","author":[{"given":"Adiba","family":"Sultana","sequence":"first","affiliation":[{"name":"Center for Systems Biology, Soochow University, Suzhou, 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3353-7897","authenticated-orcid":true,"given":"Rajeev K.","family":"Singla","sequence":"additional","affiliation":[{"name":"Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"He","sequence":"additional","affiliation":[{"name":"Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Shahin","family":"Alam","sequence":"additional","affiliation":[{"name":"Center for Systems Biology, Soochow University, Suzhou, 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-1531","authenticated-orcid":true,"given":"Bairong","family":"Shen","sequence":"additional","affiliation":[{"name":"Center for Systems Biology, Soochow University, Suzhou, 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neurol.2018.09.016","volume":"175","author":"Bouhassira D.","year":"2019","unstructured":"Bouhassira D.; Neuropathic pain: Definition, assessment and epidemiology. Rev Neurol (Paris) 2019,175(1-2),16-25","journal-title":"Rev Neurol (Paris)"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"17002","DOI":"10.1038\/nrdp.2017.2","volume":"3","author":"Colloca L.","year":"2017","unstructured":"Colloca L.; Ludman T.; Bouhassira D.; Baron R.; Dickenson A.H.; Yarnitsky D.; Freeman R.; Truini A.; Attal N.; Finnerup N.B.; Eccleston C.; Kalso E.; Bennett D.L.; Dworkin R.H.; Raja S.N.; Neuropathic pain. Nat Rev Dis Primers 2017,3,17002","journal-title":"Nat Rev Dis Primers"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1016\/j.pain.2011.06.017","volume":"152","author":"Jensen T.S.","year":"2011","unstructured":"Jensen T.S.; Baron R.; Haanp\u00e4 M.; Kalso E.; Loeser J.D.; Rice A.S.; Treede R.D.; A new definition of neuropathic pain. Pain 2011,152(10),2204-2205","journal-title":"Pain"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1097\/j.pain.0000000000000492","volume":"157","author":"Finnerup N.B.","year":"2016","unstructured":"Finnerup N.B.; Haroutounian S.; Kamerman P.; Baron R.; Bennett D.L.; Bouhassira D.; Cruccu G.; Freeman R.; Hansson P.; Nurmikko T.; Raja S.N.; Rice A.S.; Serra J.; Smith B.H.; Treede R.D.; Jensen T.S.; Neuropathic pain: an updated grading system for research and clinical practice. Pain 2016,157(8),1599-1606","journal-title":"Pain"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jviscsurg.2019.09.004","volume":"157","author":"Prudhomme M.","year":"2020","unstructured":"Prudhomme M.; Legras A.; Delorme C.; Lansaman T.; Lanteri-Minet M.; Medioni J.; Navez M.; Perrot S.; Pickering G.; Serrie A.; Viel E.; Management of neuropathic pain induced by surgery: review of the literature by a group of experts specialized in pain management, anesthesia and surgery. J Visc Surg 2020,157(1),43-52","journal-title":"J Visc Surg"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1007\/s40265-019-01132-x","volume":"79","author":"Blanton H.L.","year":"2019","unstructured":"Blanton H.L.; Brelsfoard J.; DeTurk N.; Pruitt K.; Narasimhan M.; Morgan D.J.; Guindon J.; Cannabinoids: current and future options to treat chronic and chemotherapy-induced neuropathic pain. Drugs 2019,79(9),969-995","journal-title":"Drugs"},{"key":"ref=7","first-page":"1963","volume":"17","author":"Yang X.D.","year":"2019","unstructured":"Yang X.D.; Fang P.F.; Xiang D.X.; Yang Y.Y.; Topical treatments for diabetic neuropathic pain. Exp Ther Med 2019,17(3),1963-1976","journal-title":"Exp Ther Med"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3344\/kjp.2018.31.3.155","volume":"31","author":"Thapa P.","year":"2018","unstructured":"Thapa P.; Euasobhon P.; Chronic postsurgical pain: current evidence for prevention and management. Korean J Pain 2018,31(3),155-173","journal-title":"Korean J Pain"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"537","DOI":"10.2217\/pmt-2017-0020","volume":"7","author":"Knezevic N.N.","year":"2017","unstructured":"Knezevic N.N.; Tverdohleb T.; Nikibin F.; Knezevic I.; Candido K.D.; Management of chronic neuropathic pain with single and compounded topical analgesics. Pain Manag 2017,7(6),537-558","journal-title":"Pain Manag"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/tbj.12739","volume":"23","author":"Larsson I.M.","year":"2017","unstructured":"Larsson I.M.; Ahm S\u00f8rensen J.; Bille C.; The post-mastectomy pain syndrome-a systematic review of the treatment modalities. Breast J 2017,23(3),338-343","journal-title":"Breast J"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s40122-015-0033-y","volume":"4","author":"Hagen E.M.","year":"2015","unstructured":"Hagen E.M.; Rekand T.; Management of neuropathic pain associated with spinal cord injury. Pain Ther 2015,4(1),51-65","journal-title":"Pain Ther"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"557","DOI":"10.2165\/11588940-000000000-00000","volume":"71","author":"Smith H.S.","year":"2011","unstructured":"Smith H.S.; Argoff C.E.; Pharmacological treatment of diabetic neuropathic pain. Drugs 2011,71(5),557-589","journal-title":"Drugs"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00702-020-02145-7","volume":"127","author":"Rosenberger D.C.","year":"2020","unstructured":"Rosenberger D.C.; Blechschmidt V.; Timmerman H.; Wolff A.; Treede R.D.; Challenges of neuropathic pain: focus on diabetic neuropathy. J Neural Transm (Vienna) 2020,127(4),589-624","journal-title":"J Neural Transm (Vienna)"},{"key":"ref=14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074195","volume":"8","author":"Bouhassira D.","year":"2013","unstructured":"Bouhassira D.; Letanoux M.; Hartemann A.; Chronic pain with neuropathic characteristics in diabetic patients: a French cross-sectional study. PLoS One 2013,8(9)","journal-title":"PLoS One"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1212\/01.wnl.0000259085.61898.9e","volume":"68","author":"Jensen M.P.","year":"2007","unstructured":"Jensen M.P.; Chodroff M.J.; Dworkin R.H.; The impact of neuropathic pain on health-related quality of life: review and implications. Neurology 2007,68(15),1178-1182","journal-title":"Neurology"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0304-3959(02)00452-9","volume":"103","author":"Siddall P.J.","year":"2003","unstructured":"Siddall P.J.; McClelland J.M.; Rutkowski S.B.; Cousins M.J.; A longitudinal study of the prevalence and characteristics of pain in the first 5 years following spinal cord injury. Pain 2003,103(3),249-257","journal-title":"Pain"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1212\/01.WNL.0000137047.85868.D6","volume":"63","author":"Solaro C.","year":"2004","unstructured":"Solaro C.; Brichetto G.; Amato M.P.; Cocco E.; Colombo B.; D\u2019Aleo G.; Gasperini C.; Ghezzi A.; Martinelli V.; Milanese C.; Patti F.; Trojano M.; Verdun E.; Mancardi G.L.; Pa I.M.S.S.G.; The prevalence of pain in multiple sclerosis: a multicenter cross-sectional study. Neurology PaIMS Study Group2004,63(5),919-921","journal-title":"Neurology"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.pain.2010.12.030","volume":"152","author":"Klit H.","year":"2011","unstructured":"Klit H.; Finnerup N.B.; Andersen G.; Jensen T.S.; Central poststroke pain: a population-based study. Pain 2011,152(4),818-824","journal-title":"Pain"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1177\/0269216312464408","volume":"27","author":"Rayment C.","year":"2013","unstructured":"Rayment C.; Hjermstad M.J.; Aass N.; Kaasa S.; Caraceni A.; Strasser F.; Heitzer E.; Fainsinger R.; Bennett M.I.; Neuropathic cancer pain: prevalence, severity, analgesics and impact from the European Palliative Care Research Collaborative-Computerised Symptom Assessment study. Palliat Med European Palliative Care Research Collaborative (EPCRC)2013,27(8),714-721","journal-title":"Palliat Med"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.pain.2011.10.028","volume":"153","author":"Bennett M.I.","year":"2012","unstructured":"Bennett M.I.; Rayment C.; Hjermstad M.; Aass N.; Caraceni A.; Kaasa S.; Prevalence and aetiology of neuropathic pain in cancer patients: a systematic review. Pain 2012,153(2),359-365","journal-title":"Pain"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.jpain.2012.03.009","volume":"13","author":"Gaskin D.J.","year":"2012","unstructured":"Gaskin D.J.; Richard P.; The economic costs of pain in the United States. J Pain 2012,13(8),715-724","journal-title":"J Pain"},{"key":"ref=22","author":"Christelis N.","year":"2017","unstructured":"Christelis N.;  Neuropathy, Neuropathic Pain, and Painful Peripheral Neuropathy: Many Kinds, Causes, and Treatments 2017","journal-title":"Neuropathy, Neuropathic Pain, and Painful Peripheral Neuropathy: Many Kinds, Causes, and Treatments"},{"key":"ref=23","first-page":"79","volume":"76","author":"Filimon C.","year":"1970","unstructured":"Filimon C.; [Various considerations on the results of enterocystoplasty]. J Urol Nephrol (Paris) 1970,76(1),79-89","journal-title":"J Urol Nephrol (Paris)"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/papr.12496","volume":"17","author":"Cheung C.W.","year":"2017","unstructured":"Cheung C.W.; Choi S.W.; Wong S.S.C.; Lee Y.; Irwin M.G.; Changes in prevalence, outcomes, and help-seeking behavior of chronic pain in an aging population over the last decade. Pain Pract 2017,17(5),643-654","journal-title":"Pain Pract"},{"key":"ref=25","doi-asserted-by":"publisher","DOI":"10.1177\/2058738419838383","volume":"33","author":"Cavalli E.","year":"2019","unstructured":"Cavalli E.; Mammana S.; Nicoletti F.; Bramanti P.; Mazzon E.; The neuropathic pain: an overview of the current treatment and future therapeutic approaches. Int J Immunopathol Pharmacol 2019,33","journal-title":"Int J Immunopathol Pharmacol"},{"key":"ref=26","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7917528","volume":"2016","author":"Lim E.Y.","year":"2016","unstructured":"Lim E.Y.; Kim Y.T.; Food-derived natural compounds for pain relief in neuropathic pain. BioMed Res Int 2016,2016","journal-title":"BioMed Res Int"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nrd4510","volume":"14","author":"Harvey A.L.","year":"2015","unstructured":"Harvey A.L.; Edrada-Ebel R.; Quinn R.J.; The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov 2015,14(2),111-129","journal-title":"Nat Rev Drug Discov"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"E931","DOI":"10.3390\/molecules21080931","volume":"21","author":"Chapa-Oliver A.M.","year":"2016","unstructured":"Chapa-Oliver A.M.; Mej\u00eda-Teniente L.; Capsaicin: From Plants to a Cancer-Suppressing Agent. Molecules 2016,21(8),E931","journal-title":"Molecules"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"E966","DOI":"10.3390\/molecules21080966","volume":"21","author":"Basith S.","year":"2016","unstructured":"Basith S.; Cui M.; Hong S.; Choi S.; Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases. Molecules 2016,21(8),E966","journal-title":"Molecules"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"E844","DOI":"10.3390\/molecules21070844","volume":"21","author":"Fattori V.","year":"2016","unstructured":"Fattori V.; Hohmann M.S.; Rossaneis A.C.; Pinho-Ribeiro F.A.; Verri W.A.; Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses. Molecules 2016,21(7),E844","journal-title":"Molecules"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1139\/apnm-2018-0622","volume":"44","author":"Tanr\u0131kulu-K\u00fc\u00e7\u00fck S.","year":"2019","unstructured":"Tanr\u0131kulu-K\u00fc\u00e7\u00fck S.; Ba\u015faran-K\u00fc\u00e7\u00fckgergin C.; Seyithano\u011flu M.; Do\u011fru-Abbaso\u011flu S.; Ko\u00e7ak H.; Beyhan-\u00d6zda\u015f \u015e.; \u00d6ner-\u0130yido\u011fan Y.; Effect of dietary curcumin and capsaicin on testicular and hepatic oxidant-antioxidant status in rats fed a high-fat diet. Appl Physiol Nutr Metab 2019,44(7),774-782","journal-title":"Appl Physiol Nutr Metab"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.ijpharm.2019.01.043","volume":"559","author":"Ghiasi Z.","year":"2019","unstructured":"Ghiasi Z.; Esmaeli F.; Aghajani M.; Ghazi-Khansari M.; Faramarzi M.A.; Amani A.; Enhancing analgesic and anti-inflammatory effects of capsaicin when loaded into olive oil nanoemulsion: an in vivo study. Int J Pharm 2019,559,341-347","journal-title":"Int J Pharm"},{"key":"ref=33","doi-asserted-by":"crossref","first-page":"155","DOI":"10.29252\/ibj.24.3.155","volume":"24","author":"Payab M.","year":"2020","unstructured":"Payab M.; Hasani-Ranjbar S.; Baeeri M.; Rahimifard M.; Arjmand B.; Haghi-Aminjan H.; Abdollahi M.; Larijani B.; Development of a novel anti-obesity compound with inhibiting properties on the lipid accumulation in 3T3-L1 adipocytes. Iran Biomed J 2020,24(3),155-63","journal-title":"Iran Biomed J"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/jcpt.13039","volume":"45","author":"Zhang S.","year":"2020","unstructured":"Zhang S.; Wang D.; Huang J.; Hu Y.; Xu Y.; Application of capsaicin as a potential new therapeutic drug in human cancers. J Clin Pharm Ther 2020,45(1),16-28","journal-title":"J Clin Pharm Ther"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1007\/s40265-018-0982-7","volume":"78","author":"Blair H.A.","year":"2018","unstructured":"Blair H.A.; Capsaicin 8% dermal patch: a review in peripheral neuropathic pain. Drugs 2018,78(14),1489-1500","journal-title":"Drugs"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.2147\/PPA.S76506","volume":"10","author":"Laklouk M.","year":"2016","unstructured":"Laklouk M.; Baranidharan G.; Profile of the capsaicin 8% patch for the management of neuropathic pain associated with postherpetic neuralgia: safety, efficacy, and patient acceptability. Patient Prefer Adherence 2016,10,1913-1918","journal-title":"Patient Prefer Adherence"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-3-0348-0828-6_4","volume":"68","author":"Schumacher M.","year":"2014","unstructured":"Schumacher M.; Pasvankas G.; Topical capsaicin formulations in the management of neuropathic pain. Prog Drug Res 2014,68,105-128","journal-title":"Prog Drug Res"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2147\/JPR.S9492","volume":"4","author":"Jorge L.L.","year":"2010","unstructured":"Jorge L.L.; Feres C.C.; Teles V.E.; Topical preparations for pain relief: efficacy and patient adherence. J Pain Res 2010,4,11-24","journal-title":"J Pain Res"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"Moher D.","year":"2009","unstructured":"Moher D.; Liberati A.; Tetzlaff J.; Altman D.G.; Group P.; Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med PRISMA Group2009,6(7),e1000097","journal-title":"PLoS Med"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"e709","DOI":"10.1097\/PR9.0000000000000709","volume":"4","author":"Forstenpointner J.","year":"2019","unstructured":"Forstenpointner J.; Naleschinski D.; Wasner G.; H\u00fcllemann P.; Binder A.; Baron R.; Sensitized vasoactive C-nociceptors: key fibers in peripheral neuropathic pain. Pain Rep 2019,4(1),e709","journal-title":"Pain Rep"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1002\/ejp.1378","volume":"23","author":"Perrot S.","year":"2019","unstructured":"Perrot S.; Lant\u00e9ri-Minet M.; Patients\u2019 global impression of change in the management of peripheral neuropathic pain: clinical relevance and correlations in daily practice. Eur J Pain 2019,23(6),1117-1128","journal-title":"Eur J Pain"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1080\/03007995.2018.1558850","volume":"35","author":"Lant\u00e9ri-Minet M.","year":"2019","unstructured":"Lant\u00e9ri-Minet M.; Perrot S.; QAPSA: post-marketing surveillance of capsaicin 8% patch for long-term use in patients with peripheral neuropathic pain in France. Curr Med Res Opin 2019,35(3),417-426","journal-title":"Curr Med Res Opin"},{"key":"ref=43","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4861491","volume":"2018","author":"Wang C.","year":"2018","unstructured":"Wang C.; Gu L.; Ruan Y.; Gegen T.; Yu L.; Zhu C.; Yang Y.; Zhou Y.; Yu G.; Tang Z.; Pirt together with TRPV1 is involved in the regulation of neuropathic pain. Neural Plast 2018,2018","journal-title":"Neural Plast"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1002\/ejp.1180","volume":"22","author":"Hansson P.","year":"2018","unstructured":"Hansson P.; Jensen T.S.; Kvarstein G.; Str\u00f6mberg M.; Pain-relieving effectiveness, quality of life and tolerability of repeated capsaicin 8% patch treatment of peripheral neuropathic pain in Scandinavian clinical practice. Eur J Pain 2018,22(5),941-950","journal-title":"Eur J Pain"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12883-017-0836-z","volume":"17","author":"Mankowski C.","year":"2017","unstructured":"Mankowski C.; Poole C.D.; Ernault E.; Thomas R.; Berni E.; Currie C.J.; Treadwell C.; Calvo J.I.; Plastira C.; Zafeiropoulou E.; Odeyemi I.; Effectiveness of the capsaicin 8% patch in the management of peripheral neuropathic pain in European clinical practice: the ASCEND study. BMC Neurol 2017,17(1),80","journal-title":"BMC Neurol"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"E42","DOI":"10.1111\/papr.12143","volume":"14","author":"Kern K.U.","year":"2014","unstructured":"Kern K.U.; Nowack W.; Poole C.; Treatment of neuropathic pain with the capsaicin 8% patch: is pretreatment with lidocaine necessary? Pain Pract 2014,14(2),E42-E50","journal-title":"Pain Pract"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"365","DOI":"10.2147\/JPR.S24810","volume":"4","author":"Shenoy R.","year":"2011","unstructured":"Shenoy R.; Roberts K.; Papadaki A.; McRobbie D.; Timmers M.; Meert T.; Anand P.; Functional MRI brain imaging studies using the Contact Heat Evoked Potential Stimulator (CHEPS) in a human volunteer topical capsaicin pain model. J Pain Res 2011,4,365-371","journal-title":"J Pain Res"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1097\/AJP.0000000000000473","volume":"33","author":"G\u00e1lvez R.","year":"2017","unstructured":"G\u00e1lvez R.; Navez M.L.; Moyle G.; Maih\u00f6fner C.; Stoker M.; Ernault E.; Nurmikko T.J.; Attal N.; Capsaicin 8% patch repeat treatment in nondiabetic peripheral neuropathic pain: a 52-week, open-label, single-arm, safety study. Clin J Pain 2017,33(10),921-931","journal-title":"Clin J Pain"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/AJP.0b013e31829a4ced","volume":"30","author":"Mou J.","year":"2014","unstructured":"Mou J.; Paillard F.; Turnbull B.; Trudeau J.; Stoker M.; Katz N.P.; Qutenza (capsaicin) 8% patch onset and duration of response and effects of multiple treatments in neuropathic pain patients. Clin J Pain 2014,30(4),286-294","journal-title":"Clin J Pain"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1016\/j.pain.2013.04.044","volume":"154","author":"Mou J.","year":"2013","unstructured":"Mou J.; Paillard F.; Turnbull B.; Trudeau J.; Stoker M.; Katz N.P.; Efficacy of Qutenza\u00ae (capsaicin) 8% patch for neuropathic pain: a meta-analysis of the Qutenza Clinical Trials Database. Pain 2013,154(9),1632-1639","journal-title":"Pain"},{"key":"ref=51","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007393.pub3","author":"Derry S.","year":"2013","unstructured":"Derry S.; Sven-Rice A.; Cole P.; Tan T.; Moore R.A.; Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev 2013(2)","journal-title":"Cochrane Database Syst Rev"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1185\/03007995.2013.781019","volume":"29","author":"Treede R.D.","year":"2013","unstructured":"Treede R.D.; Wagner T.; Kern K.U.; Husstedt I.W.; Arendt G.; Birklein F.; Cegla T.; Freynhagen R.; Gockel H.H.; Heskamp M.L.; Jager H.; Joppich R.; Maier C.; Leffler A.; Nagelein H.H.; Rolke R.; Seddigh S.; Sommer C.; Stander S.; Wasner G.; Baron R.; Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8% cutaneous patch in patients with localized neuropathic pain. Curr Med Res Opin 2013,29(5),527-538","journal-title":"Curr Med Res Opin"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1471-2296-14-28","volume":"14","author":"Hall G.C.","year":"2013","unstructured":"Hall G.C.; Morant S.V.; Carroll D.; Gabriel Z.L.; McQuay H.J.; An observational descriptive study of the epidemiology and treatment of neuropathic pain in a UK general population. BMC Fam Pract 2013,14,28","journal-title":"BMC Fam Pract"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2147\/JPR.S25272","volume":"5","author":"Webster L.R.","year":"2012","unstructured":"Webster L.R.; Peppin J.F.; Murphy F.T.; Tobias J.K.; Vanhove G.F.; Tolerability of NGX-4010, a capsaicin 8% patch, in conjunction with three topical anesthetic formulations for the treatment of neuropathic pain. J Pain Res 2012,5,7-13","journal-title":"J Pain Res"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"385","DOI":"10.2147\/JPR.S22954","volume":"4","author":"Peppin J.F.","year":"2011","unstructured":"Peppin J.F.; Majors K.; Webster L.R.; Simpson D.M.; Tobias J.K.; Vanhove G.F.; Tolerability of NGX-4010, a capsaicin 8% patch for peripheral neuropathic pain. J Pain Res 2011,4,385-392","journal-title":"J Pain Res"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.diabres.2011.04.010","volume":"93","author":"Webster L.R.","year":"2011","unstructured":"Webster L.R.; Peppin J.F.; Murphy F.T.; Lu B.; Tobias J.K.; Vanhove G.F.; Efficacy, safety, and tolerability of NGX-4010, capsaicin 8% patch, in an open-label study of patients with peripheral neuropathic pain. Diabetes Res Clin Pract 2011,93(2),187-197","journal-title":"Diabetes Res Clin Pract"},{"key":"ref=57","first-page":"E213","volume":"17","author":"Zis P.","year":"2014","unstructured":"Zis P.; Apsokardos A.; Isaia C.; Sykioti P.; Vadalouca A.; Posttraumatic and postsurgical neuropathic pain responsive to treatment with capsaicin 8% topical patch. Pain Physician 2014,17(2),E213-E218","journal-title":"Pain Physician"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s13760-014-0395-7","volume":"115","author":"Raber J.M.","year":"2015","unstructured":"Raber J.M.; Reichelt D.; Gr\u00fcneberg-Oelker U.; Philipp K.; Stubbe- Dr\u00e4ger B.; Husstedt I.W.; Capsaicin 8 % as a cutaneous patch (Qutenza\u2122): analgesic effect on patients with peripheral neuropathic pain. Acta Neurol Belg 2015,115(3),335-343","journal-title":"Acta Neurol Belg"},{"key":"ref=59","doi-asserted-by":"crossref","first-page":"E1049","DOI":"10.36076\/ppj\/2016.19.E1049","volume":"19","author":"Zis P.","year":"2016","unstructured":"Zis P.; Bernali N.; Argira E.; Siafaka I.; Vadalouka A.; Effectiveness and impact of capsaicin 8% patch on quality of life in patients with lumbosacral pain: an open-label study. Pain Physician 2016,19(7),E1049-E1053","journal-title":"Pain Physician"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"E161","DOI":"10.36076\/2017.1.E161","volume":"20","author":"Levesque A.","year":"2017","unstructured":"Levesque A.; Riant T.; Labat J.J.; Ploteau S.; Use of high-concentration capsaicin patch for the treatment of pelvic pain: observational study of 60 inpatients. Pain Physician 2017,20(1),E161-E167","journal-title":"Pain Physician"},{"key":"ref=61","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.clinthera.2017.02.010","volume":"39","author":"van Nooten F.","year":"2017","unstructured":"van Nooten F.; Treur M.; Pantiri K.; Stoker M.; Charokopou M.; Capsaicin 8% patch versus oral neuropathic pain medications for the treatment of painful diabetic peripheralneuropathy: a systematic literature review and network meta-analysis. Clin Ther 2017,39(4),787-803","journal-title":"Clin Ther"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1080\/17425255.2016.1184648","volume":"12","author":"Tajti J.","year":"2016","unstructured":"Tajti J.; Szok D.; Majl\u00e1th Z.; Cs\u00e1ti A.; Petrovics-Balog A.; V\u00e9csei L.; Alleviation of pain in painful diabetic neuropathy. Expert Opin Drug Metab Toxicol 2016,12(7),753-764","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/pme.12283","volume":"15","author":"McCormick Z.","year":"2014","unstructured":"McCormick Z.; Chang-Chien G.; Marshall B.; Huang M.; Harden R.N.; Phantom limb pain: a systematic neuroanatomical-based review of pharmacologic treatment. Pain Med 2014,15(2),292-305","journal-title":"Pain Med"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1002\/ejp.1155","volume":"22","author":"Cruccu G.","year":"2018","unstructured":"Cruccu G.; Nurmikko T.J.; Ernault E.; Riaz F.K.; McBride W.T.; Haanp\u00e4 M.; Superiority of capsaicin 8% patch versus oral pregabalin on dynamic mechanical allodynia in patients with peripheral neuropathic pain. Eur J Pain 2018,22(4),700-706","journal-title":"Eur J Pain"},{"key":"ref=65","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1097\/j.pain.0000000000000544","volume":"157","author":"Campbell C.M.","year":"2016","unstructured":"Campbell C.M.; Diamond E.; Schmidt W.K.; Kelly M.; Allen R.; Houghton W.; Brady K.L.; Campbell J.N.; A randomized, double-blind, placebo-controlled trial of injected capsaicin for pain in Morton\u2019s neuroma. Pain 2016,157(6),1297-1304","journal-title":"Pain"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"370","DOI":"10.2334\/josnusd.18-0355","volume":"61","author":"Okada S.","year":"2019","unstructured":"Okada S.; Katagiri A.; Saito H.; Lee J.; Ohara K.; Iinuma T.; Iwata K.; Functional involvement of nucleus tractus solitarii neurons projecting to the parabrachial nucleus in trigeminal neuropathic pain. J Oral Sci 2019,61(2),370-378","journal-title":"J Oral Sci"},{"key":"ref=67","first-page":"547","volume":"7","author":"Zhang K.","year":"2014","unstructured":"Zhang K.; Ramamurthy S.; Prihoda T.J.; Eckmann M.S.; Effect of delayed intrathecal administration of capsaicin on neuropathic pain induced by chronic constriction injury of the sciatic nerve in rats. J Pain Res 2014,7,547-554","journal-title":"J Pain Res"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1631\/jzus.B1400189","volume":"16","author":"Sa\u0142at K.","year":"2015","unstructured":"Sa\u0142at K.; Filipek B.; Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. J Zhejiang Univ Sci B 2015,16(3),167-178","journal-title":"J Zhejiang Univ Sci B"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1744-8069-8-51","volume":"8","author":"Nakao A.","year":"2012","unstructured":"Nakao A.; Takahashi Y.; Nagase M.; Ikeda R.; Kato F.; Role of capsaicin-sensitive C-fiber afferents in neuropathic pain-induced synaptic potentiation in the nociceptive amygdala. Mol Pain 2012,8,51","journal-title":"Mol Pain"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s40266-019-00739-9","volume":"37","author":"Pickering G.","year":"2020","unstructured":"Pickering G.; Lucchini C.; Topical treatment of localized neuropathic pain in the elderly. Drugs Aging 2020,37(2),83-89","journal-title":"Drugs Aging"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1159\/000339944","volume":"68","author":"Haanp\u00e4 M.","year":"2012","unstructured":"Haanp\u00e4 M.; Treede R.D.; Capsaicin for neuropathic pain: linking traditional medicine and molecular biology. Eur Neurol 2012,68(5),264-275","journal-title":"Eur Neurol"},{"key":"ref=72","first-page":"83","volume":"19","author":"Gajria C.","year":"2011","unstructured":"Gajria C.; Murray J.; Birger R.; Banarsee R.; Bennett D.L.; Tan K.; Field M.; Rice A.S.; Majeed A.; Identification of patients with neuropathic pain using electronic primary care records. Inform Prim Care 2011,19(2),83-90","journal-title":"Inform Prim Care"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1185\/030079906X80404","volume":"22","author":"van Seventer R.","year":"2006","unstructured":"van Seventer R.; Feister H.A.; Young J.P.; Stoker M.; Versavel M.; Rigaudy L.; Efficacy and tolerability of twice-daily pregabalin for treating pain and related sleep interference in postherpetic neuralgia: a 13-week, randomized trial. Curr Med Res Opin 2006,22(2),375-384","journal-title":"Curr Med Res Opin"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1111\/j.1526-4637.2009.00655.x","volume":"10","author":"Toth C.","year":"2009","unstructured":"Toth C.; Lander J.; Wiebe S.; The prevalence and impact of chronic pain with neuropathic pain symptoms in the general population. Pain Med 2009,10(5),918-929","journal-title":"Pain Med"},{"key":"ref=75","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.neurol.2018.08.005","volume":"175","author":"Attal N.","year":"2019","unstructured":"Attal N.; Pharmacological treatments of neuropathic pain: The latest recommendations. Rev Neurol (Paris) 2019,175(1-2),46-50","journal-title":"Rev Neurol (Paris)"},{"key":"ref=76","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1185\/03007995.2015.1129321","volume":"32","author":"Allegri M.","year":"2016","unstructured":"Allegri M.; Baron R.; Hans G.; Correa-Illanes G.; Mayoral Rojals V.; Mick G.; Serpell M.; A pharmacological treatment algorithm for localized neuropathic pain. Curr Med Res Opin 2016,32(2),377-384","journal-title":"Curr Med Res Opin"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","volume":"14","author":"Finnerup N.B.","year":"2015","unstructured":"Finnerup N.B.; Attal N.; Haroutounian S.; McNicol E.; Baron R.; Dworkin R.H.; Gilron I.; Haanp\u00e4 M.; Hansson P.; Jensen T.S.; Kamerman P.R.; Lund K.; Moore A.; Raja S.N.; Rice A.S.; Rowbotham M.; Sena E.; Siddall P.; Smith B.H.; Wallace M.; Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 2015,14(2),162-173","journal-title":"Lancet Neurol"},{"key":"ref=78","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3410\/M2-52","volume":"2","author":"Finnerup N.B.","year":"2010","unstructured":"Finnerup N.B.; Sindrup S.H.; Jensen T.S.; Recent advances in pharmacological treatment of neuropathic pain. F1000 Med Rep 2010,2,52","journal-title":"F1000 Med Rep"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.4065\/mcp.2009.0649","volume":"85","author":"Dworkin R.H.","year":"2010","unstructured":"Dworkin R.H.; O\u2019Connor A.B.; Audette J.; Baron R.; Gourlay G.K.; Haanp\u00e4 M.L.; Kent J.L.; Krane E.J.; Lebel A.A.; Levy R.M.; Mackey S.C.; Mayer J.; Miaskowski C.; Raja S.N.; Rice A.S.; Schmader K.E.; Stacey B.; Stanos S.; Treede R.D.; Turk D.C.; Walco G.A.; Wells C.D.; Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc 2010,85(3)(Suppl.),S3-S14","journal-title":"Mayo Clin Proc"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.nrl.2016.11.009","volume":"34","author":"Alc\u00e1ntara Montero A.","year":"2019","unstructured":"Alc\u00e1ntara Montero A.; S\u00e1nchez Carnerero C.I.; Eslicarbazepine acetate for neuropathic pain, headache, and cranial neuralgia: evidence and experience. Neurologia 2019,34(6),386-395","journal-title":"Neurologia"},{"key":"ref=81","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.2165\/11596280-000000000-00000","volume":"25","author":"Vorobeychik Y.","year":"2011","unstructured":"Vorobeychik Y.; Gordin V.; Mao J.; Chen L.; Combination therapy for neuropathic pain: a review of current evidence. CNS Drugs 2011,25(12),1023-1034","journal-title":"CNS Drugs"},{"key":"ref=82","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3344\/kjp.2010.23.2.99","volume":"23","author":"Park H.J.","year":"2010","unstructured":"Park H.J.; Moon D.E.; Pharmacologic management of chronic pain. Korean J Pain 2010,23(2),99-108","journal-title":"Korean J Pain"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/SPC.0000000000000271","volume":"11","author":"Paisley P.","year":"2017","unstructured":"Paisley P.; Serpell M.; The role of topiceuticals in cancer pain. Curr Opin Support Palliat Care 2017,11(2),93-98","journal-title":"Curr Opin Support Palliat Care"},{"key":"ref=84","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1080\/21548331.2015.1000794","volume":"43","author":"Pollack C. V.","year":"2015","unstructured":"Pollack C. V.; Viscusi E. R.; Improving acute pain management in emergency medicine Hosp Pract 2015,43(1),36-45","journal-title":"Hosp Pract"},{"key":"ref=85","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1080\/00325481.2013.1110567111","volume":"125","author":"Stanos S.P.","year":"2013","unstructured":"Stanos S.P.; Galluzzi K.E.; Topical therapies in the management of chronic pain. Postgrad Med 2013,125(4)(Suppl. 1),25-33","journal-title":"Postgrad Med"},{"key":"ref=86","volume":"96","author":"Crawford P.","year":"2017","unstructured":"Crawford P.; Xu Y.; Topical capsaicin for treatment of chronic neuropathic pain in adults. Am Fam Physician 2017,96(11)","journal-title":"Am Fam Physician"},{"key":"ref=87","doi-asserted-by":"publisher","first-page":"CD007393","DOI":"10.1002\/14651858.CD007393.pub4","volume":"1","author":"Derry S.","year":"2017","unstructured":"Derry S.; Rice A.S.; Cole P.; Tan T.; Moore R.A.; Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev 2017,1,CD007393","journal-title":"Cochrane Database Syst Rev"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.jpainsymman.2016.09.015","volume":"53","author":"Sommer C.","year":"2017","unstructured":"Sommer C.; Cruccu G.; Topical treatment of peripheral neuropathic pain: applying the evidence. J Pain Symptom Manage 2017,53(3),614-629","journal-title":"J Pain Symptom Manage"},{"key":"ref=89","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1007\/s40266-014-0218-9","volume":"31","author":"Sawynok J.","year":"2014","unstructured":"Sawynok J.; Topical analgesics for neuropathic pain in the elderly: current and future prospects. Drugs Aging 2014,31(12),853-862","journal-title":"Drugs Aging"},{"key":"ref=90","first-page":"88","volume":"7","author":"Cobzaru A.","year":"2012","unstructured":"Cobzaru A.; High-concentration capsaicin patch (qutenza) - a new step in treatment of neuropathic pain. Maedica (Buchar) 2012,7(1),88-89","journal-title":"Maedica (Buchar)"},{"key":"ref=91","doi-asserted-by":"publisher","first-page":"E66","DOI":"10.3390\/ph9040066","volume":"9","author":"Chung M.K.","year":"2016","unstructured":"Chung M.K.; Campbell J.N.; Use of capsaicin to treat pain: mechanistic and therapeutic considerations. Pharmaceuticals (Basel) 2016,9(4),E66","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref=92","doi-asserted-by":"publisher","first-page":"239","DOI":"10.2217\/pmt.12.13","volume":"2","author":"Wagner T.","year":"2012","unstructured":"Wagner T.; Roth-Daniek A.; Sell A.; England J.; Kern K.U.; Capsaicin 8% patch for peripheral neuropathic pain: review of treatment best practice from \u2018real-world\u2019 clinical experience. Pain Manag 2012,2(3),239-250","journal-title":"Pain Manag"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bbi.2013.03.002","volume":"30","author":"Hutchinson M.R.","year":"2013","unstructured":"Hutchinson M.R.; Buijs M.; Tuke J.; Kwok Y.H.; Gentgall M.; Williams D.; Rolan P.; Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection. Brain Behav Immun 2013,30,3-11","journal-title":"Brain Behav Immun"},{"key":"ref=94","first-page":"27","volume":"20","author":"Moon J.Y.","year":"2017","unstructured":"Moon J.Y.; Lee P.B.; Kim Y.C.; Lee S.C.; Nahm F.S.; Choi E.; Efficacy and safety of 0.625% and 1.25% capsaicin patch in peripheral neuropathic pain: multi-center, randomized, and semi-double blind controlled study. Pain Physician 2017,20(2),27-35","journal-title":"Pain Physician"},{"key":"ref=95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044023","volume":"7","author":"Zakir H.M.","year":"2012","unstructured":"Zakir H.M.; Mostafeezur R.M.; Suzuki A.; Hitomi S.; Suzuki I.; Maeda T.; Seo K.; Yamada Y.; Yamamura K.; Lev S.; Binshtok A.M.; Iwata K.; Kitagawa J.; Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation. PLoS One 2012,7(9)","journal-title":"PLoS One"},{"key":"ref=96","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s40265-015-0520-9","volume":"76","author":"Burness C.B.","year":"2016","unstructured":"Burness C.B.; McCormack P.L.; Capsaicin 8 % patch: a review in peripheral neuropathic pain. Drugs 2016,76(1),123-134","journal-title":"Drugs"},{"key":"ref=97","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s40122-014-0027-1","volume":"3","author":"\u00dc\u00e7eyler N.","year":"2014","unstructured":"\u00dc\u00e7eyler N.; Sommer C.; High-dose capsaicin for the treatment of neuropathic pain: what we know and what we need to know. Pain Ther 2014,3(2),73-84","journal-title":"Pain Ther"},{"key":"ref=98","doi-asserted-by":"publisher","first-page":"51","DOI":"10.21037\/jovs.2018.02.06","volume":"4","author":"Tamburini N.","year":"2018","unstructured":"Tamburini N.; Bollini G.; Volta C.A.; Cavallesco G.; Maniscalco P.; Spadaro S.; Qurantotto F.; Ragazzi R.; Capsaicin patch for persistent postoperative pain after thoracoscopic surgery, report of two cases. J Vis Surg 2018,4,51","journal-title":"J Vis Surg"},{"key":"ref=99","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1093\/bja\/aer260","volume":"107","author":"Anand P.","year":"2011","unstructured":"Anand P.; Bley K.; Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. Br J Anaesth 2011,107(4),490-502","journal-title":"Br J Anaesth"},{"key":"ref=100","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.2147\/DDDT.S142630","volume":"11","author":"Pickering G.","year":"2017","unstructured":"Pickering G.; Martin E.; Tiberghien F.; Delorme C.; Mick G.; Localized neuropathic pain: an expert consensus on local treatments. Drug Des Devel Ther 2017,11,2709-2718","journal-title":"Drug Des Devel Ther"},{"key":"ref=101","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11916-017-0615-y","volume":"21","author":"Casale R.","year":"2017","unstructured":"Casale R.; Symeonidou Z.; Bartolo M.; Topical treatments for localized neuropathic pain. Curr Pain Headache Rep 2017,21(3),15","journal-title":"Curr Pain Headache Rep"},{"key":"ref=102","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1002\/ejp.838","volume":"20","author":"Baron R.","year":"2016","unstructured":"Baron R.; Binder A.; Attal N.; Casale R.; Dickenson A.H.; Treede R.D.; Neuropathic low back pain in clinical practice. Eur J Pain 2016,20(6),861-873","journal-title":"Eur J Pain"},{"key":"ref=103","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/1471-2253-14-120","volume":"14","author":"Gim\u00e9nez-Mil\u00e0 M.","year":"2014","unstructured":"Gim\u00e9nez-Mil\u00e0 M.; Videla S.; Navarro M.A.; Faul\u00ed A.; Ojeda A.; Bogdanovich A.; Moreno L.A.; Hern\u00e1ndez-Cera C.; Busquets C.; Assessment of the feasibility of high-concentration capsaicin patches in the pain unit of a tertiary hospital for a population of mixed refractory peripheral neuropathic pain syndromes in non-diabetic patients. BMC Anesthesiol 2014,14,120","journal-title":"BMC Anesthesiol"},{"key":"ref=104","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/j.1532-2149.2013.00415.x","volume":"18","author":"Maih\u00f6fner C.G.","year":"2014","unstructured":"Maih\u00f6fner C.G.; Heskamp M.L.; Treatment of peripheral neuropathic pain by topical capsaicin: impact of pre-existing pain in the QUEPP-study. Eur J Pain 2014,18(5),671-679","journal-title":"Eur J Pain"},{"key":"ref=105","doi-asserted-by":"publisher","first-page":"e0150973","DOI":"10.1371\/journal.pone.0150973","volume":"11","author":"Mankowski C.","year":"2016","unstructured":"Mankowski C.; Patel S.; Trueman D.; Bentley A.; Poole C.; Cost-effectiveness of capsaicin 8% patch compared with pregabalin for the treatment of patients with peripheral neuropathic pain in Scotland. PLoS One 2016,11(3),e0150973","journal-title":"PLoS One"},{"key":"ref=106","first-page":"129","volume":"68","author":"Smith H.","year":"2014","unstructured":"Smith H.; Brooks J.R.; Capsaicin-based therapies for pain control. Prog Drug Res 2014,68,129-146","journal-title":"Prog Drug Res"},{"key":"ref=107","doi-asserted-by":"publisher","first-page":"107753","DOI":"10.1016\/j.neuropharm.2019.107753","volume":"160","author":"Uta D.","year":"2019","unstructured":"Uta D.; Yoshimura M.; Koga K.; Chronic pain models amplify transient receptor potential vanilloid 1 (TRPV1) receptor responses in adult rat spinal dorsal horn. Neuropharmacology 2019,160,107753","journal-title":"Neuropharmacology"},{"key":"ref=108","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1111\/bph.14044","volume":"175","author":"Moran M.M.","year":"2018","unstructured":"Moran M.M.; Szallasi A.; Targeting nociceptive transient receptor potential channels to treat chronic pain: current state of the field. Br J Pharmacol 2018,175(12),2185-2203","journal-title":"Br J Pharmacol"},{"key":"ref=109","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ejphar.2013.03.003","volume":"716","author":"Brederson J.D.","year":"2013","unstructured":"Brederson J.D.; Kym P.R.; Szallasi A.; Targeting TRP channels for pain relief. Eur J Pharmacol 2013,716(1-3),61-76","journal-title":"Eur J Pharmacol"},{"key":"ref=110","doi-asserted-by":"publisher","first-page":"238","DOI":"10.11607\/ofph.1973","volume":"32","author":"Claudino R.","year":"2018","unstructured":"Claudino R.; Nones C.; Araya E.; Chichorro J.; Analgesic effects of intranasal ketamine in rat models of facial pain. J Oral Facial Pain Headache 2018,32(3),238-346","journal-title":"J Oral Facial Pain Headache"},{"key":"ref=111","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/ALN.0b013e318260de41","volume":"117","author":"Shen J.","year":"2012","unstructured":"Shen J.; Fox L.E.; Cheng J.; Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats. Anesthesiology 2012,117(2),365-380","journal-title":"Anesthesiology"},{"key":"ref=112","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.mayocp.2012.11.015","volume":"88","author":"Argoff C.E.","year":"2013","unstructured":"Argoff C.E.; Topical analgesics in the management of acute and chronic pain. Mayo Clin Proc 2013,88(2),195-205","journal-title":"Mayo Clin Proc"},{"key":"ref=113","doi-asserted-by":"publisher","first-page":"926","DOI":"10.12968\/bjon.2011.20.15.926","volume":"20","author":"England J.","year":"2011","unstructured":"England J.; Wagner T.; Kern K.U.; Roth-Daniek A.; Sell A.; The capsaicin 8% patch for peripheral neuropathic pain. Br J Nurs 2011,20(15),926-931","journal-title":"Br J Nurs"},{"key":"ref=114","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007393.pub2","author":"Derry S.","year":"2009","unstructured":"Derry S.; Lloyd R.; Moore R.A.; McQuay H.J.; Topical capsaicin for chronic neuropathic pain in adults. Cochrane Database Syst Rev 2009(4)","journal-title":"Cochrane Database Syst Rev"},{"key":"ref=115","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1159\/000487444","volume":"101","author":"Tenreiro Pinto J.","year":"2018","unstructured":"Tenreiro Pinto J.; Pereira F.C.; Loureiro M.C.; Gama R.; Fernandes H.L.; Efficacy analysis of capsaicin 8% patch in neuropathic peripheral pain treatment. Pharmacology 2018,101(5-6),290-297","journal-title":"Pharmacology"},{"key":"ref=116","doi-asserted-by":"publisher","first-page":"9703036","DOI":"10.1155\/2016\/9703036","volume":"2016","author":"Bauchy F.","year":"2016","unstructured":"Bauchy F.; Mouraux A.; Deumens R.; Leerink M.; Ulpiano Trillig A.; le Polain de Waroux B.; Steyaert A.; Jo\u00eblle Q.L.; Forget P.; Feasibility of topical applications of natural high-concentration capsaicinoid solutions in patients with peripheral neuropathic pain: a retrospective analysis. Pain Res Manag 2016,2016,9703036","journal-title":"Pain Res Manag"},{"key":"ref=117","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/ejp.731","volume":"20","author":"Haanp\u00e4 M.","year":"2016","unstructured":"Haanp\u00e4 M.; Cruccu G.; Nurmikko T.J.; McBride W.T.; Docu Axelarad A.; Bosilkov A.; Chambers C.; Ernault E.; Abdulahad A.K.; Capsaicin 8% patch versus oral pregabalin in patients with peripheral neuropathic pain. Eur J Pain 2016,20(2),316-328","journal-title":"Eur J Pain"},{"key":"ref=118","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1177\/0333102414550107","volume":"35","author":"Gaul C.","year":"2015","unstructured":"Gaul C.; Resch S.; Application of the capsaicin 8% cutaneous patch in neuropathic pain of the head and face: a case series. Cephalalgia 2015,35(6),545-550","journal-title":"Cephalalgia"},{"key":"ref=119","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1002\/j.1532-2149.2014.00479.x","volume":"18","author":"Jensen T.S.","year":"2014","unstructured":"Jensen T.S.; H\u00f8ye K.; Fricov\u00e1 J.; Vanelderen P.; Ernault E.; Siciliano T.; Marques S.; Tolerability of the capsaicin 8% patch following pretreatment with lidocaine or tramadol in patients with peripheral neuropathic pain: a multicentre, randomized, assessor-blinded study. Eur J Pain 2014,18(9),1240-1247","journal-title":"Eur J Pain"},{"key":"ref=120","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1185\/03007995.2013.869491","volume":"30","author":"H\u00f6per J.","year":"2014","unstructured":"H\u00f6per J.; Helfert S.; Heskamp M.L.; Maih\u00f6fner C.G.; Baron R.; High concentration capsaicin for treatment of peripheral neuropathic pain: effect on somatosensory symptoms and identification of treatment responders. Curr Med Res Opin 2014,30(4),565-574","journal-title":"Curr Med Res Opin"},{"key":"ref=121","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1016\/j.pain.2013.08.001","volume":"154","author":"Knolle E.","year":"2013","unstructured":"Knolle E.; Zadrazil M.; Kovacs G.G.; Medwed S.; Scharbert G.; Schemper M.; Comparison of cooling and EMLA to reduce the burning pain during capsaicin 8% patch application: a randomized, double-blind, placebo- controlled study. Pain 2013,154(12),2729-2736","journal-title":"Pain"},{"key":"ref=122","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1111\/pme.12143","volume":"14","author":"Wagner T.","year":"2013","unstructured":"Wagner T.; Poole C.; Roth-Daniek A.; The capsaicin 8% patch for neuropathic pain in clinical practice: a retrospective analysis. Pain Med 2013,14(8),1202-1211","journal-title":"Pain Med"},{"key":"ref=123","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.sjpain.2013.04.001","volume":"4","author":"Gustorff B.","year":"2013","unstructured":"Gustorff B.; Poole C.; Kloimstein H.; Hacker N.; Likar R.; Treatment of neuropathic pain with the capsaicin 8% patch: quantitative sensory testing (QST) in a prospective observational study identifies potential predictors of response to capsaicin 8% patch treatment. Scand J Pain 2013,4(3),138-145","journal-title":"Scand J Pain"},{"key":"ref=124","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.jocn.2010.11.015","volume":"18","author":"Roberts K.","year":"2011","unstructured":"Roberts K.; Shenoy R.; Anand P.; A novel human volunteer pain model using contact heat evoked potentials (CHEP) following topical skin application of transient receptor potential agonists capsaicin, menthol and cinnamaldehyde. J Clin Neurosci 2011,18(7),926-932","journal-title":"J Clin Neurosci"}],"container-title":["Current Drug Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/188017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/188017\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/188017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T16:49:24Z","timestamp":1632502164000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/188017\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":124,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,4,21]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389200221999201116143701","relation":{},"ISSN":["1389-2002"],"issn-type":[{"value":"1389-2002","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4,21]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}