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The patients taking loop diuretics may receive other medications\nto treat comorbidities leading to drug interactions.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The literature was searched in databases such as Medline\/PMC\/PubMed, Google Scholar, Cochrane Library,\nScience Direct, EMBASE, Web of science, Ebsco, Directory of open access journals (DOAJ) and reference\nlists were used to spot relevant articles using keywords Drug interactions, Pharmacodynamic interactions, Loop\ndiuretics, Bumetanide, Ethacrynic acid, Furosemide, and Torsemide.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Loop diuretics are associated with hypokalemia, ototoxicity and other adverse effects. The drugs affected by\nhypokalemia and having the potential of inducing ototoxicity could interact with loop diuretics pharmacodynamically.\nLoop diuretics can interact with drugs such as amphotericin B, digoxin, angiotensin-converting enzyme inhibitors\n(ACE inhibitors), antidiabetic drugs, antifungal agents, dobutamine, gossypoland sotalol due to diuretic associated\nhypokalemia. In addition, the risk of ototoxicity could be enhanced by the concomitant use of loop diuretics and\ncisplatin, aminoglycoside antibiotics or phosphodiesterase 5 (PDE 5) inhibitors. Loop diuretics may also interact\npharmacodynamically with drugs like cephalosporins, ceritinib, levothyroxine, pixantrone, probenecid, lithium, nonsteroidal\nanti-inflammatory drugs (NSAIDs), sulfonylureas and herbal drugs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Clinicians, pharmacists and other health care providers should take responsibility for the safe use of\nmedications. In addition, they are required to be aware of the drugs interacting with loop diuretics to prevent adverse\ndrug interactions.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389200223666220401092112","type":"journal-article","created":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T18:09:36Z","timestamp":1649009376000},"page":"188-199","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Comprehensive Review of the Pharmacologic Perspective on Loop Diuretic Drug\nInteractions with Therapeutically Used Drugs"],"prefix":"10.2174","volume":"23","author":[{"given":"Naina Mohamed Pakkir","family":"Maideen","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Dubai Health Authority, Dubai, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkapoor","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, J.K.K. 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