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Its plasma half-life was approximately 6 h and resided at least 24 h in\nthe body. Moreover, 101BHG-D01 retained a significant amount in the nasal cavity. Finally, we found that 101BHGD01\nwas eliminated mainly in the form of stools in rats.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In conclusion, we provided pertinent reference information regarding the design and optimization of\ndrug delivery regimens for clinical trials.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389200224666221201123254","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T04:11:26Z","timestamp":1670213486000},"page":"1080-1088","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic\nReceptor Blocker, 101BHG-D01, in Dogs and Rats"],"prefix":"10.2174","volume":"23","author":[{"given":"Hao","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China"},{"name":"Department of Pulmonology, The Children\u2019s Hospital,\nNational Clinical Research Center For Child Health, Zhejiang University School of Medicine, Hangzhou, 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, The Children\u2019s Hospital,\nNational Clinical Research Center For Child Health, Zhejiang University School of Medicine, Hangzhou, 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongliang","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Respiratory Drugs Research, Zhejiang University School of Medicine, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Shen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Respiratory Drugs Research, Zhejiang University School of Medicine, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyou","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Showby Pharmaceutical Co., LTD, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[{"name":"Innovation Research Institute of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangmin","family":"Xie","sequence":"additional","affiliation":[{"name":"Key\nLaboratory of Respiratory Drugs Research, Zhejiang University School of Medicine, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Showby Pharmaceutical Co., LTD, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, The Children\u2019s Hospital,\nNational Clinical Research Center For Child Health, Zhejiang University School of Medicine, Hangzhou, 310052, China"},{"name":"Key Laboratory of Respiratory Drugs Research, Zhejiang University School of Medicine, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingshuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, The Children\u2019s Hospital,\nNational Clinical Research Center For Child Health, Zhejiang University School of Medicine, Hangzhou, 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/j.2042-7158.1960.tb12714.x","volume":"12","author":"Waser P.G.","year":"2011","unstructured":"Waser P.G.; The cholinergic receptor. 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