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Blood\nsamples were collected to extract total DNAs, followed by target sequencing based on next-generation sequencing\ntechnology. The MPA area under the curve (AUC) was calculated according to the formula established in our center.\nThe general linear model and linear regression model were used to analyze the association between SNPs and MPA\nAUC.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>A total of 689 SNPs were detected in our study, and 90 tagger SNPs were selected after quality control and\nlinkage disequilibrium analysis. The general linear model analysis showed that 9 SNPs significantly influenced MPA\nAUC. A forward linear regression was conducted, and the model with the highest identical degree (r2=0.55) included\n4 SNPs (SLCO1B1: rs4149036 [P &lt; 0.0001], ABCC2: rs3824610 [P = 0.005], POR: rs4732514 [P = 0.006], ABCC2:\nrs4148395 [P = 0.007]) and 6 clinical factors (age [P &lt; 0.0001], gender [P &lt; 0.0001], the incident of acute rejection\n(AR) [P = 0.001], albumin [P &lt; 0.0001], duration after renal transplantation [P = 0.01], lymphocyte numbers [P =\n0.026]). The most relevant SNP to MPA AUC in this model was rs4149036. The subgroup analysis showed that\nrs4149036 had a significant influence on MPA AUC in the older group (P = 0.02), high-albumin group (P = 0.01),\nmale group (P = 0.046), and both within-36-month group (P = 0.029) and after-36-month group (P = 0.041). The\nsystematic review included 4 studies, and 2 of them showed that the mutation in SLCO1B1 resulted in lower MPA\nAUC, which was contrary to our study.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>A total of 4 SNPs (rs4149036, rs3824610, rs4148395, and rs4732514) were identified to be significantly\ncorrelated with MPA AUC. Rs4149036, located in SLCO1B1, was suggested to be the most relevant SNP to MPA\nAUC, which had a stronger influence on recipients who were elder, male, or with high serum albumin. Furthermore,\n6 clinical factors, including age, gender, occurrence of acute rejection, serum albumin, time from kidney transplantation,\nand blood lymphocyte numbers, were found to affect the concentration of MPA.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389200224666230124121304","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T15:14:31Z","timestamp":1675437271000},"page":"114-123","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Influence of SLCO1B1 Polymorphisms on the Pharmacokinetics of Mycophenolic\nAcid in Renal Transplant Recipients"],"prefix":"10.2174","volume":"24","author":[{"given":"Jiawen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyun","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China"},{"name":"Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of\nMedical Quality Management, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Wei","sequence":"additional","affiliation":[{"name":"Department\nof Emergency Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeping","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","volume":"395","author":"Bikbov B.","year":"2020","unstructured":"Bikbov B.; 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