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The influence of CA on the hepatic CYPs and their gene expression was analyzed in\nrat liver by quantitative real-time polymerase chain reaction.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The plasma protein binding was found to be 84.81 \u00b1 7.70 and 96.34 \u00b1 3.12, blood-to-plasma ratio of 0.62 \u00b1\n0.16 and 0.80 \u00b1 0.23 at 1 \u03bcM and 10 \u03bcM concentrations, respectively. Again, the absolute oral bioavailability of CA\nat 100 mg\/kg was found to be 37.56 \u00b1 7.3%. The in-vivo pharmacokinetic profile of probe drugs revealed CA to have\nsignificant inducing effects on CYP1A2, 2C11, 2D2, and 2E1 after 14 days, which correlates to both in-vitro rat\nmicrosomal data and gene expression results.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Altogether, pharmacokinetic parameters reveal CA to have an affinity to distribute across different\nextravascular tissues and induce rat liver CYP enzymes.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389200224666230817101950","type":"journal-article","created":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T05:12:35Z","timestamp":1692335555000},"page":"587-598","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Preclinical Pharmacokinetics and CYP Modulation Activity of Chebulinic Acid: A\nPotent Molecule Against Metabolic Disease"],"prefix":"10.2174","volume":"24","author":[{"given":"Arpon","family":"Biswas","sequence":"first","affiliation":[{"name":"Pharmaceutics and Pharmacokinetic Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India"},{"name":"Jawaharlal Nehru\nUniversity, New Delhi, 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvesh","family":"Kumar Verma","sequence":"additional","affiliation":[{"name":"Pharmaceutics and Pharmacokinetic Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India"},{"name":"Jawaharlal Nehru\nUniversity, New Delhi, 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv","family":"Kumar","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201002, India"},{"name":"Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, 226031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tripti","family":"Mishra","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru\nUniversity, New Delhi, 110067, India"},{"name":"Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, 226031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Pharmaceutics and Pharmacokinetic Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India"},{"name":"Jawaharlal Nehru\nUniversity, New Delhi, 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Deb  Choudhury","sequence":"additional","affiliation":[{"name":"Pharmaceutics and Pharmacokinetic Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India"},{"name":"Jawaharlal Nehru\nUniversity, New Delhi, 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sristi","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Pharmaceutics and Pharmacokinetic Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin Nashik","family":"Sanap","sequence":"additional","affiliation":[{"name":"Pharmaceutics and Pharmacokinetic Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amol Chhatrapati","family":"Bisen","sequence":"additional","affiliation":[{"name":"Pharmaceutics and Pharmacokinetic Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Mishra","sequence":"additional","affiliation":[{"name":"Pharmaceutics and Pharmacokinetic Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadigoppula","family":"Narender","sequence":"additional","affiliation":[{"name":"Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, 226031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabi Sankar","family":"Bhatta","sequence":"additional","affiliation":[{"name":"Pharmaceutics and Pharmacokinetic Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.5530\/ijpi.2020.1.5","volume":"10","author":"Rimpi A.","year":"2020","unstructured":"Rimpi A.; 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