{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:12:05Z","timestamp":1763017925497},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"9","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2018,11,13]]},"abstract":"<jats:sec>\n<jats:title>Background: <\/jats:title>\n<jats:p>Common variable immunodeficiency (CVID) encompasses a heterogeneous\ngroup of primary antibody deficiency disorders characterized by recurrent infections, autoimmunity\nand malignancies. Gastrointestinal manifestations are frequently associated with CVID.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Objective: <\/jats:title>\n<jats:p>\nIn this cross-sectional study, we evaluated gastric and duodenal involvement in a cohort of\nadult patients with CVID.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>\n Upper gastrointestinal endoscopy was performed in 58 patients (26 males, mean age 47.8\u00b115.6\nyears), diagnosed with CVID according to 2014 ESID criteria. Random biopsies were collected from gastric\nantrum and descending duodenum for the all enrolled subjects. Intraepithelial lymphocytosis in descending\nduodenum was defined as the presence of 25 lymphocytes per 100 enterocytes.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results: <\/jats:title>\n<jats:p>\nThe major histopathological findings that we found were: a) chronic active gastritis (44.8%),\nHelicobacter pylori-associated (8.6%), b) chronic duodenitis (39.6%) with intraepithelial lymphocytosis\n(31%) and absence of plasma cells (18.9%) and c) autoimmune atrophic gastritis (5.2%). Three patients\n(5.2%) presented Intestinal Metaplasia (IM) of the gastric antrum. This finding was associated\nwith H. pylori infection and persisted after the eradication in one patient. IM was associated with autoimmune\natrophic gastritis in two cases. Giardia lamblia infection was observed in the duodenum samples\nfrom three patients (5.2%). A diagnosis of Gastric adenocarcinoma was made in a 58-year- old\nwoman diagnosed with gastric dysplasia one year earlier.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title \/>\n<jats:p>\nConclusion: In our cohort of CVID patients, gastro-duodenal histopathological findings, including malignancies,\nare frequent and can affect long-term prognosis. A rigorous endoscopic follow-up is needed\nin CVID patients irrespective of the gastrointestinal symptoms.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201019666181010170630","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T04:56:46Z","timestamp":1539925006000},"page":"734-741","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Gastroduodenal Disorders in Patients with CVID Undergoing Immunoglobulin Therapy"],"prefix":"10.2174","volume":"19","author":[{"given":"Gilda","family":"Varricchi","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences (DISMET), Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Pecoraro","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences (DISMET), Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovica","family":"Crescenzi","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences (DISMET), Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Marone","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Naples Federico II; Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Travaglino","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco Paolo","family":"D'Armiento","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Genovese","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences (DISMET), Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Spadaro","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences (DISMET), Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Pharmaceutical Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/166143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/166143\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/166143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T10:03:52Z","timestamp":1639130632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/166143\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,11,13]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389201019666181010170630","relation":{},"ISSN":["1389-2010"],"issn-type":[{"value":"1389-2010","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,13]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}