{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:38:17Z","timestamp":1777894697925,"version":"3.51.4"},"reference-count":34,"publisher":"Bentham Science Publishers Ltd.","issue":"13","funder":[{"DOI":"10.13039\/501100005317","name":"Kermanshah University of Medical Sciences","doi-asserted-by":"publisher","award":["3005193"],"award-info":[{"award-number":["3005193"]}],"id":[{"id":"10.13039\/501100005317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2019,10,28]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Periodontal disease is the most common oral condition that affects the tissue\nsurrounding the teeth. The oral cavity is colonized by an impressive array of micro-organisms, many of\nwhich can colonize the implants such as Guided Tissue Regeneration (GTR) often utilized in recovering\nprocedures that result in inflammation interfering with the bone regeneration.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> In the current study, a nano-hybrid GTR membrane is developed as a heliacal structure scaffold\nwith localized drug delivery function (Ibuprofen) as an anti-inflammatory agent. Polycaprolactone\n(PCL) and a blend of Polyvinyl alcohol (PVA)\/collagen (Col) (50\/50) were electrospun by electrospinning.\nIbuprofen (Ibu) was loaded once in the PCL context and once in the hydrophilic portion\n(PVA\/Col).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The in vitro release behavior was investigated in each case. Chemical and physical properties\nwere studied for each item. Morphology investigation indicated a heliacal structure with the total average\ndiameter of 1266 nm consististing of porous pores with the average diameter of 256nm.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The membranes indicated proper mechanical properties and appropriate biodegradation\nrate as a potential GTR membrane. The controlled and sustained release of Ibu was obtained from both\nPCL and PVA\/COL loaded membranes. Kinetic model study indicated the following zero-order and\nHiguchi models for the optimum case of PCL loaded and PVA\/Col Ibu loaded scaffolds respectively.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201020666190722161004","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T05:00:57Z","timestamp":1563858057000},"page":"1122-1133","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Fabrication and in-vitro Investigation of Polycaprolactone - (Polyvinyl Alcohol\/Collagen) Hybrid Nanofiber as Anti-Inflammatory Guided Tissue Regeneration Membrane"],"prefix":"10.2174","volume":"20","author":[{"given":"Mazdak","family":"Limoee","sequence":"first","affiliation":[{"name":"Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pouran","family":"Moradipour","sequence":"additional","affiliation":[{"name":"Nano Drug Delivery research center, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnaz","family":"Godarzi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Arkan","sequence":"additional","affiliation":[{"name":"Nano Drug Delivery research center, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Behbood","sequence":"additional","affiliation":[{"name":"Nano Drug Delivery research center, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/j.1600-0757.1994.tb00020.x","author":"Haffajee A.D.","year":"1994","unstructured":"Haffajee A.D.; Socransky S.S.;  Microbial etiological agents of destructive periodontal diseases 1994,78-111","journal-title":"Microbial etiological agents of destructive periodontal diseases"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","volume":"366","author":"Pihlstrom B.L.","year":"2005","unstructured":"Pihlstrom B.L.; Michalowicz B.S.; Johnson N.W.; Periodontal diseases. 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