{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:06:29Z","timestamp":1769162789508,"version":"3.49.0"},"reference-count":29,"publisher":"Bentham Science Publishers Ltd.","issue":"1","funder":[{"DOI":"10.13039\/501100002412","name":"First Affiliated Hospital of Xi\u2019an JiaoTong University","doi-asserted-by":"publisher","award":["2017QN-21"],"award-info":[{"award-number":["2017QN-21"]}],"id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xjj2018119"],"award-info":[{"award-number":["xjj2018119"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009103","name":"Education Department of Shaanxi Province","doi-asserted-by":"publisher","award":["14JK1752"],"award-info":[{"award-number":["14JK1752"]}],"id":[{"id":"10.13039\/501100009103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603305"],"award-info":[{"award-number":["81603305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972814"],"award-info":[{"award-number":["81972814"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Antidepressants and antipsychotics are widely prescribed drugs for the treatment\nof mental diseases. Therapeutic drug monitoring (TDM) is recommended for patients taking these\ndrugs to ensure pharmaceutical efficacy, medication compliance and prevent toxicity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>An ultra-high performance liquid chromatography\/tandem-mass spectrometry (UPLC-MS\/\nMS) method was developed for simultaneous determination of two Antidepressants-Fluoxetine (FLU)\nand Escitalopram (ESC), and two antipsychotics-risperidone (RIS) and aripiprazole (ARI), in human\nplasma.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The sample was processed by simple protein precipitation and the targeted analytes were\nseparated on a C18 column by gradient elution with a mobile phase containing 0.1% formic acid (v\/v)\nand acetonitrile. All the analytes were qualitative and quantitative measured by electrospray ionization\nsource with Multiple Reaction Monitoring (MRM) in positive ion mode. A total of 56 plasma samples\nwere obtained from out- or in-patients who were taking the cited four drugs for further analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The calibration curves for FLU, ESC, RIS and ARI were linear in the range of 45-1800,\n4-320, 2-200 and 50-1800 ng\/mL, respectively. The entire analytical time for the analytes was 7.0 min\nfor each run and the extraction efficiency was more than 90%. The sample was stable within various\nstorage conditions. The trough concentrations in patients were measured with the validated method.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>The developed method was successfully used for simultaneous determination of FLU,\nESC, RIS and ARI in the plasma of the patients, which provides effective technical support for routine\nTDM of these four drugs and is of great clinic value for individual therapy.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201020666190830150549","type":"journal-article","created":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T00:05:41Z","timestamp":1567209941000},"page":"60-69","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A UPLC-MS\/MS Assay for Simultaneous Determination of Two Antipsychotics and Two Antidepressants in Human Plasma and Its Application in Clinic"],"prefix":"10.2174","volume":"21","author":[{"given":"Houli","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/S0140-6736(18)32271-2","volume":"392","author":"Frankish H.","year":"2018","unstructured":"Frankish H.; Boyce N.; Horton R.; Mental health for all: A global goal. Lancet 2018,392(10157),1493-1494","journal-title":"Lancet"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1007\/s00127-016-1269-5","volume":"51","author":"Liu Z.","year":"2016","unstructured":"Liu Z.; Huang Y.; Lv P.; Zhang T.; Wang H.; Li Q.; Yan J.; Yu Y.; Kou C.; Xu X.; Lu J.; Wang Z.; Qiu H.; Xu Y.; He Y.; Li T.; Guo W.; Tian H.; Xu G.; Xu X.; Ma Y.; Wang L.; Wang L.; Yan Y.; Wang B.; Xiao S.; Zhou L.; Li L.; Tan L.; Chen H.; Ma C.; The China mental health survey: II. Design and field procedures. Soc Psychiatry Psychiatr Epidemiol 2016,51(11),1547-1557","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4103\/psychiatry.IndianJPsychiatry_102_17","volume":"59","author":"Murthy R.S.","year":"2017","unstructured":"Murthy R.S.; National mental health survey of India 2015u2016. Indian J Psychiatry 2017,59(1),21-26","journal-title":"Indian J Psychiatry"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1192\/bjp.bp.116.188078","volume":"210","author":"Thornicroft G.","year":"2017","unstructured":"Thornicroft G.; Chatterji S.; Evans-Lacko S.; Gruber M.; Sampson N.; Aguilar-Gaxiola S.; Al-Hamzawi A.; Alonso J.; Andrade L.; Borges G.; Bruffaerts R.; Bunting B.; de Almeida J.M.C.; Florescu S.; de Girolamo G.; Gureje O.; Haro J.M.; He Y.; Hinkov H.; Karam E.; Kawakami N.; Lee S.; Navarro-Mateu F.; Piazza M.; Posada-Villa J.; de Galvis Y.T.; Kessler R.C.; Under treatment of people with major depressive disorder in 21 countries. Br J Psychiatry 2017,210(2),119-124","journal-title":"Br J Psychiatry"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1016\/S0140-6736(18)31612-X","volume":"392","author":"Patel V.","year":"2018","unstructured":"Patel V.; Saxena S.; Lund C.; Thornicroft G.; Baingana F.; Bolton P.; Chisholm D.; Collins P.Y.; Cooper J.L.; Eaton J.; Herrman H.; Herzallah M.M.; Huang Y.; Jordans M.J.D.; Kleinman A.; Medina-Mora M.E.; Morgan E.; Niaz U.; Omigbodun O.; Prince M.; Rahman A.; Saraceno B.; Sarkar B.K.; De Silva M.; Singh I.; Stein D.J.; Sunkel C.; Un\u00dctzer, J. The Lancet Commission on global mental health and sustainable development. Lancet 2018,392(10157),1553-1598","journal-title":"Lancet"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s00406-005-0579-5","volume":"255","author":"Adli M.","year":"2005","unstructured":"Adli M.; Baethge C.; Heinz A.; Langlitz N.; Bauer M.; Is dose escalation of antidepressants a rational strategy after a medium-dose treatment has failed? A systematic review. Eur Arch Psychiatry Clin Neurosci 2005,255(6),387-400","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1038\/sj.npp.1301390","volume":"32","author":"Trivedi M.H.","year":"2007","unstructured":"Trivedi M.H.; Rush A.J.; Gaynes B.N.; Stewart J.W.; Wisniewski S.R.; Warden D.; Ritz L.; Luther J.F.; Stegman D.; Deveaugh-Geiss J.; Howland R.; Maximizing the adequacy of medication treatment in controlled trials and clinical practice: STAR(*)D measurement-based care. Neuropsychopharmacology 2007,32(12),2479-2489","journal-title":"Neuropsychopharmacology"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1176\/ps.2009.60.9.1164","volume":"60","author":"Addington D.","year":"2009","unstructured":"Addington D.; Best practices: Improving quality of care for patients with first-episode psychosis. Psychiatr Serv 2009,60(9),1164-1166","journal-title":"Psychiatr Serv"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1056\/NEJMoa051688","volume":"363","author":"Lieberman J.A.","year":"2010","unstructured":"Lieberman J.A.; Stroup T.S.; McEvoy J.P.; Swartz M.S.; Rosenheck R.A.; Perkins D.O.; Keefe R.S.; Davis S.M.; Davis C.E.; Lebowitz B.D.; Severe J.; Hsiao J.K.; Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators2010,363(11),1092-1093","journal-title":"N Engl J Med"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3904\/kjim.2009.24.1.1","volume":"24","author":"Kang J-S.","year":"2009","unstructured":"Kang J-S.; Lee M-H.; Overview of therapeutic drug monitoring. Korean J Intern Med (Korean Assoc Intern Med) 2009,24(1),1-10","journal-title":"Korean J Intern Med (Korean Assoc Intern Med)"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/cpt.298","volume":"99","author":"Jang S.H.","year":"2016","unstructured":"Jang S.H.; Yan Z.; Lazor J.A.; Therapeutic drug monitoring: A patient management tool for precision medicine. Clin Pharmacol Ther 2016,99(2),148-150","journal-title":"Clin Pharmacol Ther"},{"key":"ref=12","author":"Hiemke C.","unstructured":"Hiemke C.; Bergemann N.; Clement H.W.; Conca A.; Deckert J.; Domschke K.; Eckermann G.; Egberts K.; Gerlach M.; Greiner C.; Gr\u00fcnder G.; Haen E.; Havemann-Reinecke U.; Hefner G.; Helmer R.; Janssen G.; Jaquenoud E.; Laux G.; Messer T.; M\u00f6ssner R.; M\u00fcller M.J.; Paulzen M.; Pfuhlmann B.; Riederer P.; Saria A.; Schoppek B.; Schoretsanitis G.; Schwarz M.; Gracia M.S.; Stegmann B.; Steimer W.; Stingl J.C.; Uhr M.; Ulrich S.; Unterecker S.; Waschgler R.; Zernig G.; Zurek G.; Baumann P.;  Consensus Guidelines for Therapeutic Drug Monitoring\n\tin Neuropsychopharmacology: Update 2017. Pharmacopsychiatry,\n\t2018, 51(1-02), 9-62.\n                     https:\/\/www.thieme-connect.de\/products\/ejournals\/abstract\/10.1055\/s-0037-1600991"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1080\/15622975.2018.1439595","volume":"19","author":"Schoretsanitis G.","year":"2018","unstructured":"Schoretsanitis G.; Paulzen M.; Unterecker S.; Schwarz M.; Conca A.; Zernig G.; Gr\u00fcnder G.; Haen E.; Baumann P.; Bergemann N.; Clement H.W.; Domschke K.; Eckermann G.; Egberts K.; Gerlach M.; Greiner C.; Havemann-Reinecke U.; Hefner G.; Helmer R.; Janssen G.; Jaquenoud-Sirot E.; Laux G.; Messer T.; M\u00f6ssner R.; M\u00fcller M.J.; Pfuhlmann B.; Riederer P.; Saria A.; Schoppek B.; Silva Gracia M.; Stegmann B.; Steimer W.; Stingl J.C.; Uhr M.; Ulrich S.; Waschgler R.; Zurek G.; Hiemke C.; TDM in psychiatry and neurology: A comprehensive summary of the consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology, update 2017; a tool for clinicians<sup\/>. World J Biol Psychiatry 2018,19(3),162-174","journal-title":"World J Biol Psychiatry"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/S0140-6736(17)32802-7","volume":"391","author":"Cipriani A.","year":"2018","unstructured":"Cipriani A.; Furukawa T.A.; Salanti G.; Chaimani A.; Atkinson L.Z.; Ogawa Y.; Leucht S.; Ruhe H.G.; Turner E.H.; Higgins J.P.T.; Egger M.; Takeshima N.; Hayasaka Y.; Imai H.; Shinohara K.; Tajika A.; Ioannidis J.P.A.; Geddes J.R.; Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis. Lancet 2018,391(10128),1357-1366","journal-title":"Lancet"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1001\/jama.292.7.807","volume":"292","author":"March J.","year":"2004","unstructured":"March J.; Silva S.; Petrycki S.; Curry J.; Wells K.; Fairbank J.; Burns B.; Domino M.; McNulty S.; Vitiello B.; Severe J.; Treatment for Adolescents With Depression Study (TADS) Team. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents With Depression Study (TADS) randomized controlled trial. JAMA 2004,292(7),807-820","journal-title":"JAMA"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0278-5846(02)00338-X","volume":"27","author":"Vaswani M.","year":"2003","unstructured":"Vaswani M.; Linda F.K.; Ramesh S.; Role of selective serotonin reuptake inhibitors in psychiatric disorders: A comprehensive review. Prog Neuropsychopharmacol Biol Psychiatry 2003,27(1),85-102","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13034-018-0243-2","volume":"12","author":"Dodsworth T.","year":"2018","unstructured":"Dodsworth T.; Kim D.D.; Procyshyn R.M.; Ross C.J.; Honer W.G.; Barr A.M.; A systematic review of the effects of CYP2D6 phenotypes on risperidone treatment in children and adolescents. Child Adolesc Psychiatry Ment Health 2018,12,37","journal-title":"Child Adolesc Psychiatry Ment Health"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jad.2018.06.043","volume":"241","author":"Calabrese J.R.","year":"2018","unstructured":"Calabrese J.R.; Sanchez R.; Jin N.; Amatniek J.; Cox K.; Johnson B.; Perry P.P.; Hertel P.; Such P.; McQuade R.D.; Nyilas M.; Carson W.H.; The safety and tolerability of aripiprazole once-monthly as maintenance treatment for bipolar I disorder: A double-blind, placebo-controlled, randomized withdrawal study. J Affect Disord 2018,241,425-432","journal-title":"J Affect Disord"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.pharep.2016.09.010","volume":"69","author":"Kami\u0144ska K.","year":"2017","unstructured":"Kami\u0144ska K.; Noworyta-Soko\u0142owska K.; Jurczak A.; G\u00f3rska A.; Rog\u00f3\u017c Z.; Go\u0142embiowska K.; Risperidone and escitalopram co-administration: A potential treatment of schizophrenia symptoms with less side effects. Pharmacol Rep 2017,69(1),13-21","journal-title":"Pharmacol Rep"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.pharep.2018.04.009","volume":"70","author":"Kami\u0144ska K.","year":"2018","unstructured":"Kami\u0144ska K.; G\u00f3rska A.; Noworyta-Soko\u0142owska K.; Wojtas A.; Rog\u00f3\u017c Z.; Go\u0142embiowska K.; The effect of chronic co-treatment with risperidone and novel antidepressant drugs on the dopamine and serotonin levels in the rats frontal cortex. Pharmacol Rep 2018,70(5),1023-1031","journal-title":"Pharmacol Rep"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.pharep.2018.02.022","volume":"70","author":"Rog\u00f3\u017c Z.","year":"2018","unstructured":"Rog\u00f3\u017c Z.; W\u0105sik A.; Lorenc-Koci E.; Combined treatment with aripiprazole and antidepressants reversed some MK-801-induced schizophrenia-like symptoms in mice. Pharmacol Rep 2018,70(4),623-630","journal-title":"Pharmacol Rep"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neuropharm.2018.11.006","volume":"146","author":"Ebrahimzadeh M.","year":"2019","unstructured":"Ebrahimzadeh M.; El Mansari M.; Blier P.; Synergistic effect of aripiprazole and escitalopram in increasing serotonin but not norepinephrine neurotransmission in the rat hippocampus. Neuropharmacology 2019,146,12-18","journal-title":"Neuropharmacology"},{"key":"ref=23","author":"Canbolat F.","year":"2018","unstructured":"Canbolat F.; Erinc D.M.T.; Evrensel A.; Aydin A.; Tarhan K.N.; Quantitation of escitalopram and its metabolites by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS\/MS) in psychiatric patients: New metabolic ratio establishmet. Basic Clin Pharmacol Toxicol 2018","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.clinbiochem.2017.10.002","volume":"52","author":"da Silva A.C.C.","year":"2018","unstructured":"da Silva A.C.C.; Raasch J.R.; Vargas T.G.; Peteffi G.P.; Hahn R.Z.; Antunes M.V.; Perassolo M.S.; Linden R.; Simultaneous determination of fluoxetine and norfluoxetine in dried blood spots using high-performance liquid chromatography-tandem mass spectrometry. Clin Biochem 2018,52,85-93","journal-title":"Clin Biochem"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1093\/chromsci\/bmy024","volume":"56","author":"Miroshnichenko I.I.","year":"2018","unstructured":"Miroshnichenko I.I.; Baymeeva N.V.; Simultaneous determination of antipsychotic drugs and their active metabolites by LC-MS-MS and its application to therapeutic drug monitoring. J Chromatogr Sci 2018,56(6),510-517","journal-title":"J Chromatogr Sci"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.jchromb.2018.05.026","volume":"1092","author":"Ni X-J.","year":"2018","unstructured":"Ni X-J.; Wang Z-Z.; Shang D-W.; Lu H-Y.; Zhang M.; Wen Y-G.; Simultaneous analysis of olanzapine, fluoxetine, and norfluoxetine in human plasma using liquid chromatography-mass spectrometry and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci 2018,1092,506-514","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref=27","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5187084","volume":"2017","author":"Ezzeldin E.","year":"2017","unstructured":"Ezzeldin E.; Abo-Talib N.F.; Tammam M.H.; UPLC-Tandem Mass Spectrometry Method for simultaneous determination of fluoxetine, risperidone, and its active metabolite 9-hydroxyrisperidone in plasma: Application to pharmacokinetics study in rats. J Anal Methods Chem 2017,2017","journal-title":"J Anal Methods Chem"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.2174\/1389201019666180209164444","volume":"18","author":"Shaikh A.S.","year":"2017","unstructured":"Shaikh A.S.; Guo R.; Therapeutic drug monitoring of phenytoin by simple, rapid, accurate, highly sensitive and novel method and its clinical applications. Curr Pharm Biotechnol 2017,18(13),1098-1105","journal-title":"Curr Pharm Biotechnol"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jpba.2012.01.016","volume":"64-65","author":"Wang C.","year":"2012","unstructured":"Wang C.; Li S.; Tang Y.; Wang S.; Zhang Y.; Fan G.; Li L.; Zhang Y.; Microdialysis combined with liquid chromatography-tandem mass spectrometry for the determination of levo-tetrahydropalmatine in the rat striatum. J Pharm Biomed Anal 2012,64-65,1-7","journal-title":"J Pharm Biomed Anal"}],"container-title":["Current Pharmaceutical Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/174583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T14:12:33Z","timestamp":1581084753000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/174583\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,7]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,7]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389201020666190830150549","relation":{},"ISSN":["1389-2010"],"issn-type":[{"value":"1389-2010","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1,7]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-22","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}