{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:23:00Z","timestamp":1747207380244,"version":"3.40.5"},"reference-count":66,"publisher":"Bentham Science Publishers Ltd.","issue":"13","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2020,11,28]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Aplastic Anemia (AA) is also known as idiopathic aplastic anemia (IAA) and the production\nof new blood cells ceases in AA, which leads to an abnormal hematological syndrome such as pancytopenia\nand suppression of hypo-cellular bone marrow. The pathophysiology of AA in most cases is\nimmune-mediated and is stimulated by type 1 cytotoxic T cells. Reliable early diagnostic tests of IAA\nare not yet available, therefore most of the cases are identified in advanced stages. Recently, abnormal\nimmune response and hematopoietic cell deficiencies are defined genetically, such as in target cells of\ntelomere repair gene mutations and by the dysregulation of T-cell activation pathways. Importantly,\nanti-thymocyte globulins and cyclosporine-associated immunosuppression are successful treatments\nfor restoring blood cell production in most of the cases, however, clonal hematologic diseases remain\nchallenging. In the current review, we have discussed the common practices in the treatment, pathophysiology,\ndiagnosis, and management of AA.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201021666191210141426","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T13:10:46Z","timestamp":1575983446000},"page":"1282-1288","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Idiopathic Aplastic Anemia in Children and Adults: Diagnosis, Treatments, and Management - A Review"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6446-3571","authenticated-orcid":true,"given":"Fatmah S.","family":"Alqahtany","sequence":"first","affiliation":[{"name":"Department of Pathology, Hematopathology Unit, College of Medicine, King Saud University, King Saud University Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.146522","volume":"101","author":"Cuglievan B.","year":"2016","unstructured":"Cuglievan B.; DePombo A.; De Angulo G.; Aplastic anemia: The correct nomenclature matters. 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