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Therefore, we examined if changes in neurocellular GMFB\nexpression and release can be used to assess brain injury following ischaemia.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods and Results:<\/jats:title>\n<jats:p> Immunofluorescence staining, Western blotting, immunohistochemistry and\nELISA were used to measure GMFB in cultured neurons and astrocytes, rat brain tissues and plasma\nsamples from stroke model rats and stroke patients, while cell viability assays, TTC staining and micro-\nPET were used to assess neural cell death and infarct severity. Immunofluorescence and immunohistochemistry\nrevealed GMFB expression mainly in astrocyte and neuronal nuclei but also in neuronal\naxons and dendrites. Free GMFB concentration increased progressively in the culture medium during\nhypoxia-hypoglycaemia treatment. Plasma GMFB concentration increased in rats subjected to middle\ncerebral artery occlusion (MCAO, a model of stroke-reperfusion) and in stroke patients. Plasma\nGMFB in MCAO model rats was strongly correlated with infarct size (R2=0.9582). Plasma GMFB\nconcentration was also markedly elevated in stroke patients within 24 h of onset and remained elevated\nfor more than one week. Conversely, plasma GMFB elevations were not significant in myocardial infarct\npatients and stroke patients without infarction.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>GMFB has the prerequisite stability, expression specificity and response dynamics to\nserve as a reliable indicator of ischaemic injury in animal models and stroke patients. Plasma GMFB\nmay be a convenient non-invasive adjunct to neuroimaging for stroke diagnosis and prognosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201021666200210102425","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T14:21:15Z","timestamp":1581344475000},"page":"955-963","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of the Clinical Diagnostic Value of GMFB in Cerebral Infarction"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-8550","authenticated-orcid":true,"given":"Zhaohu","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion, Guangzhou First People\u2019s Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-5557","authenticated-orcid":true,"given":"Zhiwu","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Laboratory Science, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Guangzhou First People\u2019s Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9622-3193","authenticated-orcid":true,"given":"Huikuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Guangzhou First People\u2019s Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.bbapap.2018.06.007","volume":"1866","author":"Maheshwari D.","year":"2018","unstructured":"Maheshwari D.; Shukla V.K.; Jain A.; Tripathi S.; Kumar D.; Arora A.; Solution structure and dynamics of glia maturation factor from Caenorhabditis elegans. 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