{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:36:57Z","timestamp":1780054617932,"version":"3.54.0"},"reference-count":59,"publisher":"Bentham Science Publishers Ltd.","issue":"11","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2020,9,21]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> Probiotics can be used for the treatment of viral gastroenteritis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This systematic review is to evaluate the evidence regarding the effect of probiotics on human\ncases of viral gastroenteritis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The objective of this review is to evaluate the effectiveness of probiotics against placebo or\nstandard treatment for viral gastroenteritis. A comprehensive search of Cochrane Library, EMBASE,\nMEDLINE via PubMed and Ovid databases, and unpublished studies (till 27 January 2018) was conducted\nfollowed by a process of study selection and critical appraisal by two independent reviewers.\nRandomized controlled trials assessing probiotic administration in human subjects infected with any\nspecies of gastroenteritis viruses were considered for inclusion. Only studies with a confirmed viral\ncause of infection were included. This study was developed using the JBI methodology for systematic\nreviews, which is in accordance with the PRISMA guideline. Meta-analysis was conducted where feasible.\nData were pooled using the inverse variance method with random effects models and expressed\nas Mean Differences (MDs) with 95% Confidence Intervals (CIs). Heterogeneity was assessed by\nCochran Q statistic and quantified by the I2 statistic. We included 17 RCTs, containing 3,082 patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Probiotics can improve symptoms of viral gastroenteritis, including the duration of diarrhea\n(mean difference 0.7 days, 95% CI 0.31 to 1.09 days, n = 740, ten trials) and duration of hospitalization\n(mean difference 0.76 days, 95% CI 0.61 to 0.92 days, n = 329, four trials).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The results of this review show that the administration of probiotics in patients with viral\ngastroenteritis should be considered.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201021666200416123931","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T11:31:01Z","timestamp":1587036661000},"page":"1042-1051","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Systematic Review and Meta-Analysis: The Effectiveness of Probiotics for Viral Gastroenteritis"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8554-1276","authenticated-orcid":true,"given":"Fereshteh","family":"Ansari","sequence":"first","affiliation":[{"name":"Research Center for Evidence-Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5879-6166","authenticated-orcid":true,"given":"Fariba","family":"Pashazadeh","sequence":"additional","affiliation":[{"name":"Research Center for Evidence-Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaheh","family":"Nourollahi","sequence":"additional","affiliation":[{"name":"Research Center for Evidence-Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1494-7097","authenticated-orcid":true,"given":"Sakineh","family":"Hajebrahimi","sequence":"additional","affiliation":[{"name":"Research Center for Evidence-Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7091-5842","authenticated-orcid":true,"given":"Zachary","family":"Munn","sequence":"additional","affiliation":[{"name":"The Joanna Briggs Institute, The University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9113-794X","authenticated-orcid":true,"given":"Hadi","family":"Pourjafar","sequence":"additional","affiliation":[{"name":"Department of Food Sciences and Nutrition, Maragheh University of Medical Sciences, Maragheh, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","author":"Wiener C.","year":"2008","unstructured":"Wiener C.; Fauci A.S.; Braunwald E.; Kasper D.L.; Hauser S.L.; Longo D.L.; Jameson J.L.; Loscalzo J.;  Harrison\u2019s principles of internal medicine, self-assessment and board review 2008","journal-title":"Harrison\u2019s principles of internal medicine, self-assessment and board review"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.3389\/fmicb.2019.01957","volume":"10","author":"Malik Y.S.","year":"2019","unstructured":"Malik Y.S.; Verma A.K.; Kumar N.; Touil N.; Karthik K.; Tiwari R.; Bora D.P.; Dhama K.; Ghosh S.; Hemida M.G.; Abdel-Moneim A.S.; B\u00e1nyai K.; Vlasova A.N.; Kobayashi N.; Singh R.K.; Advances in diagnostic approaches for viral etiologies of diarrhea: From the lab to the field. 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