{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T17:17:24Z","timestamp":1756574244335,"version":"3.40.5"},"reference-count":38,"publisher":"Bentham Science Publishers Ltd.","issue":"13","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2020,11,28]]},"abstract":"<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Heart dysfunctions are the major complications of trastuzumab in patients with\nHuman Epidermal growth factor Receptor-2 (HER2)-positive breast cancers.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> In this study, the cytotoxicity of trastuzumab on H9c2 cardiomyoblasts was demonstrated,\nand the proteome changes of cells were investigated by a tandem mass tagging quantitative approach.\nThe Differentially Abundant Proteins (DAPs) were identified and functionally enriched.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>We determined that carvedilol, a non-selective beta-blocker, could effectively inhibit\ntrastuzumab toxicity when administrated in a proper dose and at the same time. The proteomics analysis\nof carvedilol co-treated cardiomyoblasts showed complete or partial reversion in expressional levels\nof trastuzumab-induced DAPs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Downregulation of proteins involved in the translation biological process is one of the\nmost important changes induced by trastuzumab and reversed by carvedilol. These findings provide\nnovel insights to develop new strategies for the cardiotoxicity of trastuzumab.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201021666200515135548","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T10:13:50Z","timestamp":1589537630000},"page":"1377-1385","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Proteomics Analysis of Trastuzumab Toxicity in the H9c2 Cardiomyoblast Cell Line and its Inhibition by Carvedilol"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6550-0036","authenticated-orcid":true,"given":"Elham","family":"Beiranvand","sequence":"first","affiliation":[{"name":"Protein Chemistry and Proteomics Laboratory, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-1144","authenticated-orcid":true,"given":"Fatemeh","family":"Torkashvand","sequence":"additional","affiliation":[{"name":"Protein Chemistry and Proteomics Laboratory, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5476-8010","authenticated-orcid":true,"given":"Seyed N.","family":"Ostad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-4984","authenticated-orcid":true,"given":"Mehdi","family":"Mirzaie","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3636-0780","authenticated-orcid":true,"given":"Esmat M.","family":"Ardakani","sequence":"additional","affiliation":[{"name":"Protein Chemistry and Proteomics Laboratory, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4139-5948","authenticated-orcid":true,"given":"Fatemeh","family":"Zandi","sequence":"additional","affiliation":[{"name":"Protein Chemistry and Proteomics Laboratory, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2080-7402","authenticated-orcid":true,"given":"Soroush","family":"Sardari","sequence":"additional","affiliation":[{"name":"Protein Chemistry and Proteomics Laboratory, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-4721","authenticated-orcid":true,"given":"Ghasem H.","family":"Salekdeh","sequence":"additional","affiliation":[{"name":"Department of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5123-4155","authenticated-orcid":true,"given":"Mohammad A.","family":"Shokrgozar","sequence":"additional","affiliation":[{"name":"National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0295-5922","authenticated-orcid":true,"given":"Behrouz","family":"Vaziri","sequence":"additional","affiliation":[{"name":"Protein Chemistry and Proteomics Laboratory, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s12885-018-4183-2","volume":"18","author":"M\u00fcller V.","year":"2018","unstructured":"M\u00fcller V.; Clemens M.; Jassem J.; Al-Sakaff N.; Auclair P.; N\u00fcesch E.; Holloway D.; Shing M.; Bang Y-J.; Long-term trastuzumab (Herceptin\u00ae) treatment in a continuation study of patients with HER2-positive breast cancer or HER2-positive gastric cancer. BMC Cancer 2018,18(1),295","journal-title":"BMC Cancer"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"227","DOI":"10.5114\/aoms.2012.28549","volume":"8","author":"Piotrowski G.","year":"2012","unstructured":"Piotrowski G.; Gawor R.; Stasiak A.; Gawor Z.; Potemski P.; Banach M.; Cardiac complications associated with trastuzumab in the setting of adjuvant chemotherapy for breast cancer overexpressing human epidermal growth factor receptor type 2 - a prospective study. Arch Med Sci 2012,8(2),227-235","journal-title":"Arch Med Sci"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1161\/CIRCULATIONAHA.107.690487","volume":"116","author":"Lemmens K.","year":"2007","unstructured":"Lemmens K.; Doggen K.; De Keulenaer G.W.; Role of neuregulin-1\/ErbB signaling in cardiovascular physiology and disease: Implications for therapy of heart failure. Circulation 2007,116(8),954-9460","journal-title":"Circulation"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1007\/s00018-019-03340-w","volume":"77","author":"Leemasawat K.","year":"2020","unstructured":"Leemasawat K.; Phrommintikul A.; Chattipakorn S.C.; Chattipakorn N.; Mechanisms and potential interventions associated with the cardiotoxicity of ErbB2-targeted drugs: Insights from in vitro, in vivo, and clinical studies in breast cancer patients. Cell Mol Life Sci 2020,77(8),1571-1589","journal-title":"Cell Mol Life Sci"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.biopha.2017.06.033","volume":"93","author":"Kabel A.M.","year":"2017","unstructured":"Kabel A.M.; Elkhoely A.A.; Targeting proinflammatory cytokines, oxidative stress, TGF-\u03b21 and STAT-3 by rosuvastatin and ubiquinone to ameliorate trastuzumab cardiotoxicity. Biomed Pharmacother 2017,93,17-26","journal-title":"Biomed Pharmacother"},{"key":"ref=6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079543","volume":"8","author":"ElZarrad M.K.","year":"2013","unstructured":"ElZarrad M.K.; Mukhopadhyay P.; Mohan N.; Enkui H.; Milos D.; Dianne S.H.; Yi S.; Pal P.; Wen J.W.; Trastuzumab alters the expression of genes essential for cardiac function and induces ultrastructural changes of cardiomyocytes in mice. PLoS One 2013,8(11)","journal-title":"PLoS One"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1074\/jbc.M804570200","volume":"284","author":"Gordon L.I.","year":"2009","unstructured":"Gordon L.I.; Burke M.A.; Singh A.T.; Prachand S.; Lieberman E.D.; Sun L.; Naik T.J.; Prasad S.V.N.; Ardehali H.; Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways. J Biol Chem 2009,284(4),2080-2087","journal-title":"J Biol Chem"},{"key":"ref=8","first-page":"70","volume":"16","author":"Zeglinski M.","year":"2011","unstructured":"Zeglinski M.; Ludke A.; Jassal D.S.; Singal P.K.; Trastuzumab-induced cardiac dysfunction: A \u2018dual-hit\u2019. Exp Clin Cardiol 2011,16(3),70-74","journal-title":"Exp Clin Cardiol"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"289","DOI":"10.5966\/sctm.2011-0016","volume":"1","author":"Barth A.S.","year":"2012","unstructured":"Barth A.S.; Zhang Y.; Li T.; Smith R.R.; Chimenti I.; Terrovitis I.; Davis D.R.; Kizana E.; Ho A.S.; O\u2019Rourke B.; Wolff A.C.; Gerstenblith G.; Marb\u00e1n E.; Functional impairment of human resident cardiac stem cells by the cardiotoxic antineoplastic agent trastuzumab. Stem Cells Transl Med 2012,1(4),289-297","journal-title":"Stem Cells Transl Med"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.breast.2017.10.010","volume":"37","author":"Gujral D.M.","year":"2018","unstructured":"Gujral D.M.; Lloyd G.; Bhattacharyya S.; Effect of prophylactic betablocker or ACE inhibitor on cardiac dysfunction","journal-title":"Breast"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.yjmcc.2004.05.024","volume":"37","author":"Spallarossa P.","year":"2004","unstructured":"Spallarossa P.; Garibaldi S.; Altieri P.; et al Carvedilol prevents doxorubicin-induced free radical release and apoptosis in cardiomyocytes in vitro. J Mol Cell Cardiol 2004,37(4),837-846","journal-title":"J Mol Cell Cardiol"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/S0024-3205(99)00362-8","volume":"65","author":"Matsui H.","year":"1999","unstructured":"Matsui H.; Morishima I.; Numaguchi Y.; Toki Y.; Okumura K.; Hayakawa T.; Protective effects of carvedilol against doxorubicin-induced cardiomyopathy in rats. Life Sci 1999,65(12),1265-1274","journal-title":"Life Sci"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1016\/j.jacc.2006.07.052","volume":"48","author":"Kalay N.","year":"2006","unstructured":"Kalay N.; Basar E.; Ozdogru I.; et al Protective effects of carvedilol against anthracycline-induced cardiomyopathy. J Am Coll Cardiol 2006,48(11),2258-2262","journal-title":"J Am Coll Cardiol"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"5913","DOI":"10.1002\/jcb.27880","volume":"120","author":"Zhang Y.","year":"2019","unstructured":"Zhang Y.; Deng H.; Zhou H.; et al A novel agent attenuates cardiotoxicity and improves antitumor activity of doxorubicin in breast cancer cells. J Cell Biochem 2019,120(4),5913-5922","journal-title":"J Cell Biochem"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.mrgentox.2019.03.004","volume":"841","author":"Arbo M.D.","year":"2019","unstructured":"Arbo M.D.; Altknecht L.F.; Cattani S.; et al in vitro cardiotoxicity evaluation of graphene oxide. Mutat Res 2019,841,8-13","journal-title":"Mutat Res"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/2050-6511-14-46","volume":"14","author":"Enayetallah A.E.","year":"2013","unstructured":"Enayetallah A.E.; Puppala D.; Ziemek D.; Fischer J.E.; Kantesaria S.; Pletcher M.T.; Assessing the translatability of in vivo cardiotoxicity mechanisms to in vitro models using causal reasoning. BMC Pharmacol Toxicol 2013,14,46","journal-title":"BMC Pharmacol Toxicol"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"Mosmann T.","year":"1983","unstructured":"Mosmann T.; Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983,65(1-2),55-63","journal-title":"J Immunol Methods"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"12685","DOI":"10.1038\/s41598-017-12858-7","volume":"7","author":"Mirzaei M.","year":"2017","unstructured":"Mirzaei M.; Gupta V.B.; Chick J.M.; et al Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes. Sci Rep 2017,7(1),12685","journal-title":"Sci Rep"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fnmol.2019.00024","volume":"12","author":"Deng L.","year":"2019","unstructured":"Deng L.; Pushpitha K.; Joseph C.; et al amyloid \u03b2 induces early changes in the ribosomal machinery, cytoskeletal organization and oxidative phosphorylation in retinal photoreceptor cells. Front Mol Neurosci 2019,12,24","journal-title":"Front Mol Neurosci"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-1-4939-6740-7_5","author":"Mirzaei M.","year":"2017","unstructured":"Mirzaei M.; Pascovici D.; Wu J.X.; Chick J.; Wu Y.; Cooke B.; Haynes P.; Molloy M.P.; TMT one-stop shop: From reliable sample preparation to computational analysis platform. Proteome Bioinformat 2017,45-66","journal-title":"Proteome Bioinformat"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1016\/j.jacc.2019.03.495","volume":"73","author":"Guglin M.","year":"2019","unstructured":"Guglin M.; Krischer J.; Tamura R.; et al Randomized trial of lisinopril versus carvedilol to prevent trastuzumab cardiotoxicity in patients with breast cancer. J Am Coll Cardiol 2019,73(22),2859-2868","journal-title":"J Am Coll Cardiol"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"16657","DOI":"10.1073\/pnas.0707936104","volume":"104","author":"Wisler J.W.","year":"2007","unstructured":"Wisler J.W.; DeWire S.M.; Whalen E.J.; et al A unique mechanism of \u03b2-blocker action: Carvedilol stimulates \u03b2-arrestin signaling. Proc Natl Acad Sci USA 2007,104(42),16657-16662","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1172\/JCI31901","volume":"117","author":"Noma T.","year":"2007","unstructured":"Noma T.; Lemaire A.; Naga P.S.V.; et al Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J Clin Invest 2007,117(9),2445-2458","journal-title":"J Clin Invest"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"14555","DOI":"10.1073\/pnas.0804745105","volume":"105","author":"Kim I-M.","year":"2008","unstructured":"Kim I-M.; Tilley D.G.; Chen J.; et al \u03b2-blockers alprenolol and carvedilol stimulate \u03b2-arrestin-mediated EGFR transactivation. Proc Natl Acad Sci USA 2008,105(38),14555-14560","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1159\/000450825","volume":"136","author":"Zheng W.","year":"2017","unstructured":"Zheng W.; Shang X.; Zhang C.; Gao X.; Robinson B.; Liu J.; The effects of carvedilol on cardiac function and the AKT\/XIAP signaling pathway in diabetic cardiomyopathy rats. Cardiology 2017,136(3),204-211","journal-title":"Cardiology"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/sj.bjc.6604901","volume":"100","author":"Xu Y.","year":"2009","unstructured":"Xu Y.; Benlimame N.; Su J.; He Q.; Alaoui-Jamali M.A.; Regulation of focal adhesion turnover by ErbB signalling in invasive breast cancer cells. Br J Cancer 2009,100(4),633-643","journal-title":"Br J Cancer"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1093\/toxsci\/kfu150","volume":"141","author":"Eldridge S.","year":"2014","unstructured":"Eldridge S.; Guo L.; Mussio J.; Furniss M.; Hamre J.; III, Davis, M. Examining the protective role of ErbB2 modulation in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci 2014,141(2),547-559","journal-title":"Toxicol Sci"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12967-016-0885-x","volume":"14","author":"Peng H.","year":"2016","unstructured":"Peng H.; Gong P.G.; Li J.B.; et al The important role of the receptor for activated C kinase 1 (RACK1) in nasopharyngeal carcinoma progression. J Transl Med 2016,14(1),131","journal-title":"J Transl Med"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"e1120382","DOI":"10.1080\/21690731.2015.1120382","volume":"3","author":"Gallo S.","year":"(Austin) 2015","unstructured":"Gallo S.; Manfrini N.; Working hard at the nexus between cell signaling and the ribosomal machinery: An insight into the roles of RACK1 in translational regulation Translation (Austin) 2015,3(2),e1120382","journal-title":"Translation"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/aas.12282","volume":"58","author":"Annborn M.","year":"2014","unstructured":"Annborn M.; Dankiewicz J.; Nielsen N.; et al CT-proAVP (copeptin), MR-proANP and Peroxiredoxin 4 after cardiac arrest: Release profiles and correlation to outcome. Acta Anaesthesiol Scand 2014,58(4),428-436","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s11481-017-9733-x","volume":"12","author":"Kim E.A.","year":"2017","unstructured":"Kim E.A.; Na J.M.; Kim J.; Choi S.Y.; Ahn J.Y.; Cho S.W.; Neuroprotective effect of 3-(naphthalen-2-yl(propoxy)methyl)-azetidine hydrochloride on brain ischaemia\/reperfusion injury. J Neuroimmune Pharmacol 2017,12(3),447-461","journal-title":"J Neuroimmune Pharmacol"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1016\/j.bbalip.2016.02.011","volume":"1861","author":"Zlobine I.","year":"2016","unstructured":"Zlobine I.; Gopal K.; Ussher J.R.; Lipotoxicity in obesity and diabetes-related cardiac dysfunction. Biochim Biophys Acta 2016,1861(10),1555-1568","journal-title":"Biochim Biophys Acta"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1159\/000276567","volume":"25","author":"Zamorano-Le\u00f3n J.J.","year":"2010","unstructured":"Zamorano-Le\u00f3n J.J.; Modrego J.; Mateos-C\u00e1ceres P.J.; et al A proteomic approach to determine changes in proteins involved in the myocardial metabolism in left ventricles of spontaneously hypertensive rats. Cell Physiol Biochem 2010,25(2-3),347-358","journal-title":"Cell Physiol Biochem"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"190","DOI":"10.2174\/157488407781668776","volume":"2","author":"Fragasso G.","year":"2007","unstructured":"Fragasso G.; Spoladore R.; Cuko A.; Palloshi A.; Modulation of fatty acids oxidation in heart failure by selective pharmacological inhibition of 3-ketoacyl coenzyme-A thiolase. Curr Clin Pharmacol 2007,2(3),190-196","journal-title":"Curr Clin Pharmacol"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1054\/jcaf.2002.130238","volume":"8","author":"Podbregar M.","year":"2002","unstructured":"Podbregar M.; Voga G.; Effect of selective and nonselective beta-blockers on resting energy production rate and total body substrate utilization in chronic heart failure. J Card Fail 2002,8(6),369-378","journal-title":"J Card Fail"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"H971","DOI":"10.1152\/ajpheart.00360.2018","volume":"316","author":"Zhuang L.","year":"2019","unstructured":"Zhuang L.; Li C.; Chen Q.; et al Fatty acid-binding protein 3 contributes to ischemic heart injury by regulating cardiac myocyte apoptosis and MAPK pathways. Am J Physiol Heart Circ Physiol 2019,316(5),H971-H984","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"H716","DOI":"10.1152\/ajpheart.00455.2011","volume":"302","author":"Su C.C.","year":"2012","unstructured":"Su C.C.; Yang J.Y.; Leu H.B.; Chen Y.; Wang P.H.; Mitochondrial Akt-regulated mitochondrial apoptosis signaling in cardiac muscle cells. Am J Physiol Heart Circ Physiol 2012,302(3),H716-H723","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref=38","first-page":"126","volume":"66","author":"Krischer J.","year":"(Stuttg) 2016","unstructured":"Krischer J.; Tamura R.; Fink A.; Bello-Matricaria L.; McCaskill-Stevens M.; Munster P.N.; Carvedilol suppresses apoptosis and ion channel remodelling of HL-1 cardiac myocytes expressing E334K cMyBPC Drug Res (Stuttg) 2016,66(3),126-129","journal-title":"Drug Res"}],"container-title":["Current Pharmaceutical Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/181992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/181992\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/181992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T13:53:39Z","timestamp":1626962019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/181992\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,28]]},"references-count":38,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,11,28]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389201021666200515135548","relation":{},"ISSN":["1389-2010"],"issn-type":[{"type":"print","value":"1389-2010"}],"subject":[],"published":{"date-parts":[[2020,11,28]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}