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ZIKV infection is\nassociated with a range of neurological complications such as the Congenital Zika Syndrome and Guillain\nBarr\u00e9 Syndrome. Despite the magnitude of recent outbreaks, there is no specific therapy to prevent\nor to alleviate disease pathology.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>To investigate the role of P-MAPA immunomodulator in Zika-infected THP-1 cells.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>THP-1 cells were subjected to Zika virus infection (Multiplicity of Infection = 0.5) followed\nby treatment with P-MAPA for until 96 hours post-infection. After that, the cell death was analyzed by\nannexin<jats:sup>+<\/jats:sup>\/ PI<jats:sup>+<\/jats:sup> and caspase 3\/ 7<jats:sup>+<\/jats:sup> staining by flow cytometry. In addition, virus replication and cell proliferation\nwere accessed by RT-qPCR and Ki67 staining, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>We demonstrate that P-MAPA in vitro treatment significantly reduces Zika virus-induced cell\ndeath and caspase-3\/7 activation on THP-1 infected cells, albeit it has no role in virus replication and\ncell proliferation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>Our study reveals that P-MAPA seems to be a satisfactory alternative to inhibit the effects\nof Zika virus infection in mammalian cells.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201021666200602140005","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T18:29:40Z","timestamp":1591122580000},"page":"514-522","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The P-MAPA Immunomodulator Partially Prevents Apoptosis Induced by Zika Virus Infection in THP-1 Cells"],"prefix":"10.2174","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9844-8270","authenticated-orcid":true,"given":"Morganna C.","family":"Lima","sequence":"first","affiliation":[{"name":"Department of Virology and Experimental Therapy, Aggeu Magalhaes Institute, Oswaldo Cruz Foundation\/FIOCRUZ, Recife,Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa A.N.","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Virology and Experimental Therapy, Aggeu Magalhaes Institute, Oswaldo Cruz Foundation\/FIOCRUZ, Recife,Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0887-8163","authenticated-orcid":true,"given":"Clarice N.L.","family":"de Morais","sequence":"additional","affiliation":[{"name":"Department of Virology and Experimental Therapy, Aggeu Magalhaes Institute, Oswaldo Cruz Foundation\/FIOCRUZ, Recife,Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-3353","authenticated-orcid":true,"given":"Larissa I.O.","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Cesmac University Center, Maceio,Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6792-0288","authenticated-orcid":true,"given":"Bruno M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Biological Sciences Institute, Pernambuco University, Recife,Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2818-3107","authenticated-orcid":true,"given":"Iseu N.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Farmabrasilis R&amp;D Division, Sao Paulo,Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1846-6007","authenticated-orcid":true,"given":"Rafael F.O.","family":"Franca","sequence":"additional","affiliation":[{"name":"Department of Virology and Experimental Therapy, Aggeu Magalhaes Institute, Oswaldo Cruz Foundation\/FIOCRUZ, Recife,Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1002\/jmv.24563","volume":"88","author":"Ramos da Silva S.","year":"2016","unstructured":"Ramos da Silva S.; Gao S-J.; Zika virus: An update on epidemiology, pathology, molecular biology, and animal model. 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