{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T03:34:23Z","timestamp":1779939263668,"version":"3.53.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"11","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Background: Rheumatoid Arthritis (RA) is a common connective tissue disease, characteristic\nof chronic and invasive synovitis in single or multiple joints and vasculitis. RA is a heterogeneous\ndisease with unclear pathogenesis. Therefore, exploring the etiology and pathogenesis of the disease is\nessential for identifying new promising treatment strategies for RA. Accumulated data have implicated\nthe significant role of non-coding RNA in RA, some of which are demonstrated to regulate inflammation\nand autoimmunity in RA through the Toll-Like Receptor (TLR) signaling pathway. To clarify the\nmechanism of non-coding RNA regulating the generation of proinflammatory mediators is helpful for\nunderstanding the pathogenesis of RA. Moreover, these well established non-coding RNAs can serve\nas novel biotargets for RA diagnosis and treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> Here, we summarize currently available data on non-coding RNAs, TLRs, and the underlying molecular mechanisms in RA. This review will provide insight into the potential use of non-coding RNA as disease diagnosis and treatment\nmarkers for RA.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201021666201001142829","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T13:24:37Z","timestamp":1601558677000},"page":"1490-1500","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutic Potential of Non-Coding RNAs and TLR Signalling Pathways in Rheumatoid Arthritis"],"prefix":"10.2174","volume":"22","author":[{"given":"Jingjing","family":"Liu","sequence":"first","affiliation":[{"name":"Clinical Medicine College, Weifang Medical University, Weifang 261000, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Medicine College, Weifang Medical University, Weifang 261000, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Experimental Training Center, Weifang Medical University, Weifang 261000, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5164-8112","authenticated-orcid":true,"given":"Fengxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Allergy of the First Affiliated Hospital, Weifang Medical University, Weifang 261000, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Pharmaceutical Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/186462","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/186462\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/186462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T16:45:13Z","timestamp":1628613913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/186462\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,8,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389201021666201001142829","relation":{},"ISSN":["1389-2010"],"issn-type":[{"value":"1389-2010","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}