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Glucocorticoids are the first choice\nof the treatment, but some hormone-resistant patients are not sensitive to glucocorticoid therapy. The\npathogenesis is not yet known. In this study, we aim to construct the HEI-OC1 cell line stably overexpressing\nGlucocorticoid Receptor Beta (GR\u03b2), and identify its exact role in the cases of glucocorticoidresistant\nsudden deafness.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>We used the endotoxin lipopolysaccharide-stimulated cochlear hair cells (HEI-OC1) to investigate\nthe relationship of inflammation factor IL-2, TNF alpha, and SRp30c with the high expression\nGR\u03b2. We built a stable GR\u03b2 high expression HEI-OC1 cell line and clarified its effects on the\ntherapeutic effect of dexamethasone. MTT assay, colony formation assay, CCK-8 assay, Western blot,\nand RT-qPCR were utilized for characterizations.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Dexamethasone reduced the LPS-induced inflammatory response from HEI-OC1 cells (p&lt;0.05),\ndetected by MTT assay. Dexamethasone could protect HEI-OC1 cells, but its protective effect was weakened\ndue to the transfection of SRp30c over-expression plasmid (p&lt;0.05). The transfection of SRp30c\nover-expression plasmid in HEI-OC1 cells could elevate the expressions of GR\u03b2 (p&lt;0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>: We clarified the mechanisms of high expression of GR\u03b2 in glucocorticoid-resistant sudden\nsensorineural hearing loss, and proved that the inhibition of SRp30c may act as a new treatment\nway of glucocorticoid-resistant sudden sensorineural hearing loss.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201021666201008163534","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T04:58:50Z","timestamp":1602219530000},"page":"1206-1215","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["GR\u03b2 Regulates Glucocorticoid Resistance in Sudden Sensorineural Hearing Loss"],"prefix":"10.2174","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2180-4652","authenticated-orcid":true,"given":"Xubo","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1681-1452","authenticated-orcid":true,"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese medicine, Nanchang, Jiangxi, 330004,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0840-1258","authenticated-orcid":true,"given":"Chunping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8682-0867","authenticated-orcid":true,"given":"Lihua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006,China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/MAO.0000000000002229","volume":"40","author":"Staecker H.","year":"2019","unstructured":"Staecker H.; Jokovic G.; Karpishchenko S.; Kienle-Gogolok A.; Krzyzaniak A.; Lin C-D.; Navratil P.; Tzvetkov V.; Wright N.; Meyer T.; Efficacy and safety of AM-111 in the treatment of acute unilateral sudden deafness-a double-blind, randomized, placebo-controlled phase 3 study. 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