{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:07:45Z","timestamp":1792624065513,"version":"4.5.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"11","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Stem cell therapy efficiently targets the brain for most neurological disorders like migraine,\nParkinsonism, schizophrenia, Alzheimer\u2019s disease, and brain injury. The major obstacles in\npotential brain targeting are the physiological barriers like blood-brain-barrier and bloodcerebrospinal\nfluid barrier. The conventional injectable route or direct transplantation of stem cells\nresults in brain injury and is less feasible clinically. The alternative to these invasive routes is the\nintranasal route that is non-invasive, easily repeatable technique and highly effective in brain targeting\nwithout crossing the blood-brain barrier. Extensive research has been undertaken for the delivery\nof stem cells to the brain via the intranasal route that holds great potential in overcoming the existing\nbarriers. Nanotechnology is emerging as a novel interdisciplinary field in the arena of stem\ncell research. The combination of nanotechnology coupled with stem cell therapy has led to synergistic\noutcomes in diagnostic and therapeutic applications of neurological diseases. This review\nprovides insights into stem cell-based nanotherapy for brain targeting via the intranasal route.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201021666201218130947","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T05:56:05Z","timestamp":1608530165000},"page":"1466-1481","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Advances in Stem Cell Therapy for Brain Diseases via the Intranasal Route"],"prefix":"10.2174","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2035-5207","authenticated-orcid":true,"given":"Preeti","family":"Dali","sequence":"first","affiliation":[{"name":"Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM\u2019s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-7645","authenticated-orcid":true,"given":"Pravin","family":"Shende","sequence":"additional","affiliation":[{"name":"Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM\u2019s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Pharmaceutical Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/189254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189254\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/189254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T16:45:11Z","timestamp":1628613911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189254\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,8,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389201021666201218130947","relation":{},"ISSN":["1389-2010"],"issn-type":[{"value":"1389-2010","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}