{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:39:25Z","timestamp":1763037565050,"version":"3.37.3"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"12","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772094","81974289"],"award-info":[{"award-number":["81772094","81974289"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2021,9,2]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>N-Acetylcysteine (NAC) has been proposed to be used to treat Coronavirus Disease 2019\n(COVID-19). By reviewing the existing pathological studies of COVID-19, it was found that abundant\nmucus secretion, formation of a hyaline membrane (supportive of acute respiratory distress\nsyndrome), and interstitial fibrous exudation may be important characteristics of COVID-19 and\npathological targets of drug therapy. In addition, multiple extrapulmonary organ injuries in COVID-\n19 may be associated with cytokine storm. NAC is an important antioxidant and anti-inflammatory\ndrug. NAC has been demonstrated to have mucolytic effects in bronchitis, relieve respiratory failure\nin acute respiratory distress syndrome, and inhibit fibrous exudation in interstitial lung disease in\nclinical studies. These findings suggest that NAC may have a therapeutic effect on the pathological\ntargets of COVID-19. Furthermore, NAC decreases TNF-\u03b1, IL-1\u03b2, IL-6, IL-8, IL-10, and IL-17 serum\nlevels in patients with sepsis, severe burns, acute liver failure, or peritoneal dialysis and may\nalso reduce cytokine storm in COVID-19. The antiviral effect of NAC on other respiratory viruses\nmay also benefit COVID-19 patients. Summarizing the potential mechanisms of NAC in treating\nCOVID-19 suggests that the role of NAC in COVID-19 treatment is worthy of further research.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201021999201228212043","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T06:23:32Z","timestamp":1609223012000},"page":"1584-1590","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Potential Mechanism of N-acetylcysteine in Treating COVID-19"],"prefix":"10.2174","volume":"22","author":[{"given":"Nan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aie","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second People's Hospital of Yichang, Yichang 443000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenbing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Pharmaceutical Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/189560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189560\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/189560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T18:07:54Z","timestamp":1630951674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189560\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,2]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,9,2]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389201021999201228212043","relation":{},"ISSN":["1389-2010"],"issn-type":[{"type":"print","value":"1389-2010"}],"subject":[],"published":{"date-parts":[[2021,9,2]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}