{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:39:33Z","timestamp":1762508373568,"version":"3.40.5"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"12","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2021,9,2]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Since its origin in the Wuhan province of China in December 2019, Coronavirus Disease 19\n(COVID-19) has spread to most parts of the world and has infected millions of people. However, the\nsignificant variability in the mortality rate across the world indicates some underlying factors, especially\nthe immunity factors that may have a potential role in this variability. One such factor that is being\ndiscussed and tested is the Bacillus Calmette-Guerin (BCG) vaccine. The available evidence suggests\nthat BCG vaccination provides broad protection against respiratory infections as well as other infections.\nTherefore, BCG may prove to be a barrier for COVID-19 infection and may offer a ray of\nhope. In this review, we contrasted BCG vaccination program with COVID-19 mortality and analyzed\ntrained immunity and cross protection against unrelated pathogens due to BCG vaccination. On analyzing\nthe available data, we observed that countries without universal BCG vaccination policy are\nseverely affected, while countries having universal BCG policies are less affected. Based on these data,\nwe propose that the SARS-CoV-2 related qualified immunity, cross protection against unrelated pathogens\nand COVID-19 impact variations could be partly explained by the different national policies regarding\nBCG childhood vaccination. The combination of reduced morbidity and mortality may make\nBCG vaccination a potential new tool in the fight against COVID-19.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201022666210202142811","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T04:15:41Z","timestamp":1612325741000},"page":"1574-1583","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["BCG Vaccination Program Mitigates COVID19 Related Mortality: A Reality Check"],"prefix":"10.2174","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9222-6423","authenticated-orcid":true,"given":"Archana","family":"Pandita","sequence":"first","affiliation":[{"name":"Cancer Pharmacology Division, Indian Institute of Integrative Medicine (IIIM), Canal Road, Jammu-180001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-3910","authenticated-orcid":true,"given":"Audesh","family":"Bhat","sequence":"additional","affiliation":[{"name":"Centre for Molecular Biology, Central University of Jammu, Jammu-181143, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-9011","authenticated-orcid":true,"given":"Anita","family":"Koul","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, CMF College of Physiotherapy, Pune-411033, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8532-7421","authenticated-orcid":true,"given":"Shashank K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Cancer Pharmacology Division, Indian Institute of Integrative Medicine (IIIM), Canal Road, Jammu-180001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Pharmaceutical Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/191029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/191029\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/191029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T18:07:52Z","timestamp":1630951672000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/191029\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,2]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,9,2]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389201022666210202142811","relation":{},"ISSN":["1389-2010"],"issn-type":[{"type":"print","value":"1389-2010"}],"subject":[],"published":{"date-parts":[[2021,9,2]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}