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Cardiovascular disorders are treated with stenting, coronary bypass surgery grafting, anticoagulants, antiplatelet agents, and other pharmacological and surgical procedures; however, these have limitations due to their ad-verse effects. Fibrinolytic agents degrade fibrin through enzymatic and biochemical processes. There are various enzymes that are currently used as a treatment for CVDs, like streptokinase, nattokinase, staphylokinase, urokinase, etc. These enzymes are derived from various sources, like bacteria, fungi, algae, marine organisms, plants, snakes, and other organisms. This review deals with the fibrinolytic enzymes, their mechanisms, sources, and their therapeutic potential.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201023666220104143113","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T07:58:07Z","timestamp":1641369487000},"page":"1336-1345","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Fibrinolytic Enzyme - An Overview"],"prefix":"10.2174","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1914-1378","authenticated-orcid":true,"given":"Devika","family":"Rengaswamy","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Aarupadai Institute of Technology, Vinayaka Missions University, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-2393","authenticated-orcid":true,"given":"Parveen","family":"Abdul Rahim","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Aarupadai Institute of Technology, Vinayaka Missions University, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1016\/j.biotechadv.2015.02.014","volume":"33","author":"Choi J.M.","year":"2015","unstructured":"Choi J.M.; Han S.S.; Kim H.S.; Industrial applications of enzyme biocatalysis: Current status and future aspects. 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