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The indiscriminate use of antibiotics, due to the development of antimicrobial resistance, poses an unprecedented prob-lem for human civilization. Bacterial infections are difficult to cure because of the propensity of microbes to acquire resistance to a wide range of antimicrobial drugs. New compounds are being explored and quantified for possible antibacterial activity with little or no side effects. Research-ers are investigating the range of therapeutic plants mentioned in Unani, Ayurveda, and Siddha around the globe. Known and commonly acclaimed global databases such as PubMed, Research Gate, Science Direct, Google Scholar were searched using different search strings such as Indian medicinal plants, multidrug resistance (MDR), thin layer chromatography (TLC), antimicrobials, and Synergism were used in diverse combinations to reclaim numerous citations associated with this area. Thus, the current review aims to shed a light on the information of medicinal plants as a potential foundation of herbal drugs and elucidate how synergism and TLC bioautography play a crucial role in finding antimicrobial compounds.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1389201023666220126115656","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T23:59:52Z","timestamp":1643241592000},"page":"1527-1540","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Synergy based Extracts of Medicinal Plants: Future Antimicrobials to Combat\nMultidrug Resistance"],"prefix":"10.2174","volume":"23","author":[{"given":"Syed Akhtar","family":"Husain","sequence":"first","affiliation":[{"name":"Department of Biosciences,\nJamia Millia Islamia, New Delhi, 110025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeed","family":"Ahmad","sequence":"first","affiliation":[{"name":"Bioactive Natural Product Laboratory,\nSchool of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sageer","family":"Abass","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Jamia Millia Islamia, New Delhi, 110025, India"},{"name":"Bioactive Natural Product Laboratory,\nSchool of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India"},{"name":"Department of Biosciences,\nJamia Millia Islamia, New Delhi, 110025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabea","family":"Parveen","sequence":"additional","affiliation":[{"name":"Bioactive Natural Product Laboratory,\nSchool of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India"},{"name":"Department of Biosciences,\nJamia Millia Islamia, New Delhi, 110025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Irfan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Jamia Millia Islamia, New Delhi, 110025, India"},{"name":"Bioactive Natural Product Laboratory,\nSchool of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bisma","family":"Jan","sequence":"additional","affiliation":[{"name":"Bioactive Natural Product Laboratory,\nSchool of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"e1002184","DOI":"10.1371\/journal.pmed.1002184","volume":"13","author":"de Kraker M.E.","year":"2016","unstructured":"de Kraker M.E.; Stewardson A.J.; Harbarth S.; Will 10 million people die a year due to antimicrobial resistance by 2050? 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