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Their impaired functioning can be observed during the course of psoriatic\narthritis. Currently, the best-known class of biological drugs is the inhibitors of the proinflammatory\ncytokine TNF-\u03b1, including adalimumab.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The aim of this study was to assess changes in the expression of MAP kinase genes in\npatients with psoriatic arthritis treated with adalimumab, as well as to determine which of the analyzed\ntranscripts could be used as a diagnostic or therapeutic target.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>An analysis was performed on the total RNA extracted from PBMCs of patients with\npsoriatic arthritis before and after three months of adalimumab therapy as well as from a control\ngroup. Changes in the expression of the mitogen-activated protein kinase genes were assessed\nusing the HG-U133A 2.0 oligonucleotide microarray method, while the obtained results were validated\nusing the real-time RT-qPCR method.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Using the oligonucleotide microarray method, 14 genes coded for proteins from the\nMAPK group were identified with at least a two-fold change of expression in the control group\nand during adalimumab therapy. Validation of the results confirmed a statistically significant decrease\nin the transcriptional activity of the MAP2K2 gene in the group of patients three months\nafter the administration of adalimumab relative to the control group.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Adalimumab therapy alters the expression of MAPK-coding genes. The assessment\nof the number of MAP2K2 mRNA molecules can potentially be used in diagnostic analyses or in\nmonitoring adalimumab therapy.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201023666220628111644","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T11:50:59Z","timestamp":1656417059000},"page":"330-340","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The MAP2K2 Gene as Potential Diagnostic Marker in Monitoring\nAdalimumab Therapy of Psoriatic Arthritis"],"prefix":"10.2174","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9854-2569","authenticated-orcid":true,"given":"Barbara","family":"Strza\u0142ka-Mrozik","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Faculty of Pharmaceutical Sciences in\nSosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0706-0543","authenticated-orcid":true,"given":"Agata","family":"Krawczyk","sequence":"additional","affiliation":[{"name":"Department of Nutrigenomics and Bromatology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University\nof Silesia in Katowice, Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karol","family":"Juszczyk","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Faculty of Pharmaceutical Sciences in\nSosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-7006","authenticated-orcid":true,"given":"Magdalena","family":"Kimsa-Dudek","sequence":"additional","affiliation":[{"name":"Department of Nutrigenomics and Bromatology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University\nof Silesia in Katowice, Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0501-7592","authenticated-orcid":true,"given":"Dominika","family":"Wcis\u0142o-Dziadecka","sequence":"additional","affiliation":[{"name":"Department of Cosmetology, Faculty of\nPharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-0409","authenticated-orcid":true,"given":"Joanna","family":"Gola","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Faculty of Pharmaceutical Sciences in\nSosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"1","author":"Nadal-Ribelles M.","year":"2018","unstructured":"Nadal-Ribelles M.; Sole C.; Martinez-Cebrian G.; Posas F.; de Nadal E.;  Shaping the Transcriptional Landscape through MAPK Signaling 2018,1-22","journal-title":"Shaping the Transcriptional Landscape through MAPK Signaling"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.3390\/ijms21031102","volume":"21","author":"Lee S.","year":"2020","unstructured":"Lee S.; Rauch J.; Kolch W.; Targering MAPK signaling in cancer: Mechanism of drug resistance and sensitivity. 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