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The expression of TUBB4A in SKCM cell line was verified by RT-qPCR, and the immunohistochemistry of TUBB4A in SKCM and normal skin tissues were gained from Human Protein Atlas. Seven target prediction databases predicted potential microRNAs(miRNAs), and upstream long non-coding RNAs(lncRNAs) were predicted by starBase. The co-expressed gene of TUBB4A was obtained using the two online analysis sites UALCAN and starBase. These co-expressed genes were performed by enrichment analysis and immune infiltration result was obtained by the TIMER2 online database. The receiver operating characteristic(ROC) curve was applied to evaluate the diagnostic value of TUBB4A in the SKCM group and normal skin group, and a new nomogram about TUBB4A was constructed to forecast the survival rate of SKCM patients at 1, 3, and 5 years.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Firstly, we found DLL3 and TUBB4A were significantly higher expressed in skin cutaneous melanoma compared with normal skin. Subsequently, by analyzing progress free interval(PFI), disease-specific survival(DSS), and disease-free survival(DFS), only TUBB4A was the most potent gene for inhibiting shin cutaneous melanoma progression. In gene ontology(GO)\/ kyoto encyclopedia of genes and genomes(KEGG) analysis, TUBB4A may be a key role in the progression of skin cutaneous melanoma by regulating mitochondrial function and affecting cellular metabolism, possibly related to the immune infiltration of CD4+Th1 cells and NK cells. The upstream non-coding RNA(ncRNA) acts through the SNHG16-hsa-let-7b-5p-TUBB4A axis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>In conclusion, we elucidated the regulatory role of the SNHG16-hsa-let-7b-5p-TUBB4A axis in the progression of skin cutaneous melanoma by modulating mitochondrial function to affect cellular metabolism. TUBB4A may be a promising diagnostic biomarker and therapeutic target for skin cutaneous melanoma.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201023666220928120902","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T11:33:13Z","timestamp":1664451193000},"page":"791-809","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A\n(mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma"],"prefix":"10.2174","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9338-5859","authenticated-orcid":true,"given":"Jia","family":"Yan","sequence":"first","affiliation":[{"name":"Digestive Department, University-Town Hospital of Chongqing Medical University, Chongqing 401331, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8653-0616","authenticated-orcid":true,"given":"Guanghua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center\nfor Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing\nKey Laboratory of Child Infection and Immunity, Chongqing 400014, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrg3074","volume":"12","author":"Esteller M.","year":"2011","unstructured":"Esteller M.; Non-coding RNAs in human disease. 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