{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:15:49Z","timestamp":1780359349660,"version":"3.54.1"},"reference-count":21,"publisher":"Bentham Science Publishers Ltd.","issue":"10","funder":[{"DOI":"10.13039\/501100012155","name":"National Institutes for Medical Research Development (NIMAD), Tehran, Iran","doi-asserted-by":"publisher","award":["983297"],"award-info":[{"award-number":["983297"]}],"id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPB"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Chrysin (CH) is one of the important natural flavonoids with antioxidant\nand anti-inflammatory activity. The aim of this study was to assess the protective effects of CH on\nbiochemical indexes and histopathological changes in the liver of male Wistar rats exposed to chlorpyrifos\n(CPF).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>We induced sub-chronic toxicity in rats using CPF (10 mg\/kg\/day, orally) and administrated\nCH at 12.5, 25, and 50 mg\/kg\/day for 45 days.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>In this study, CPF increased liver enzyme activities compared with the control group (p &lt; \n0.05), and co-treated CH with CPF reduced them compared with the non-treated CPF group (p &lt; \n0.05). A significant reduction in the liver GSH concentration along with a significant elevation in the\nconcentrations of MDA and NO in the CPF group was observed compared with the control group (p\n&lt; 0.001). However, CH at a dose of 50 mg could reverse them nearly to the control group (p &lt; \n0.001). In the CPF, CPF + CH1, and CPF + CH2 groups, a marked (p &lt;  0.05) increase was found in\nthe serum concentration of IL-6 compared with the control animals. No significant changes were\nfound in the IL-6 concentration of the CPF + CH3 compared with the controls. Moreover, the coadministration\nof CH plus CPF induced histopathological alterations in liver.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>These results suggest that CH attenuates hepatic enzymes and histopathological alterations\ninduced by CPF via modulating oxidative stress and inflammatory indices in rats.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201024666221025094643","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T04:30:15Z","timestamp":1666758615000},"page":"1291-1296","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Protective Effect of Chrysin Against Chlorpyrifos-induced Hepatotoxicity\nin Rats: Biochemical and Histopathological Approaches in a Sub-chronic\nStudy"],"prefix":"10.2174","volume":"24","author":[{"given":"Saeed","family":"Samarghandian","sequence":"first","affiliation":[{"name":"Healthy Ageing Research Centre,\nNeyshabur University of Medical Sciences, Neyshabur, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Roshanravan","sequence":"additional","affiliation":[{"name":"Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahereh","family":"Farkhondeh","sequence":"additional","affiliation":[{"name":"Department of Toxicology and\nPharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Darroudi","sequence":"additional","affiliation":[{"name":"Department of Basic\nMedical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"110731","DOI":"10.1016\/j.ecoenv.2020.110731","volume":"200","author":"Huang X.","year":"2020","unstructured":"Huang X.; Cui H.; Duan W.; Ecotoxicity of chlorpyrifos to aquatic organisms: A review. 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