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Furthermore, the data from\nthe experiment on gouty rats induced by intra-articular injection of MSU crystal confirmed that\nUTLOH-4e markedly ameliorated rat paw swelling, articular synovium inflammation and reduced\nthe concentration of IL-1\u03b2 and TNF-\u03b1 in serum through down-regulating NLRP3 protein expression.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>These results manifested that UTLOH-4e ameliorates GA induced by MSU crystals,\nwhich contributes to the modulation of NF-\u03baB\/ NLRP3 signaling pathway, suggesting that UTLOH-\n4e is a promising and potent drug candidate for the prevention and treatment of gouty arthritis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201024666230420101219","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T12:57:01Z","timestamp":1681995421000},"page":"350-364","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Leflunomide Analog, UTLOH-4e, Ameliorates Gouty Arthritis\nInduced by Monosodium Urate Via NF-\u03baB\/NLRP3 Signaling Pathway"],"prefix":"10.2174","volume":"25","author":[{"given":"Tianmin","family":"Yuan","sequence":"first","affiliation":[{"name":"Translational Chinese Medicine Key Laboratory of Sichuan Province, Sichuan Academy of Chinese Medicine Sciences,\nChengdu, Sichuan, 610041, P.R. 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