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Available therapeutic agents only provide\nsymptomatic relief and their use are limited due to serious side effects. Recent research has recognized\nflavonoids as potential multi-target biomolecules that can reduce the pathogenesis of AD.\nNaringin, a natural citrus flavonoid has been traditionally used to treat various NDs including AD,\nand has gained special attention because exhibits a neuroprotective effect by affecting numerous\nsignaling pathways with minimum adverse effects. Naringin reduces deposition of A\u03b2, hyperphosphorylation\nof tau protein, cholinergic dysfunction, oxidative stress burden, mitochondrial toxicity,\nthe activity of glutamate receptors, and apoptosis of the neuronal cells. Additionally, it reduces the\nexpression of phosphorylated-P38\/P38 and the NF-\u03baB signaling pathway, showing that a wide\nrange of molecular targets is involved in naringin's neuroprotective action. The present study describes\nthe possible pharmacological targets, signaling pathways, and molecular mechanisms of\nnaringin involved in neuroprotection against AD-like pathology. Based on the above pre-clinical\nreports it can be concluded that naringin could be an alternative therapeutic agent for the management\nof AD-like manifestation. Thus, there is a strong recommendation to perform more preclinical\nand clinical studies to develop naringin as a novel molecule that could be a multi-target drug to\ncounteract AD.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389201024666230801095526","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T12:29:05Z","timestamp":1690892945000},"page":"1112-1123","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pre-clinical Evidence-based Neuroprotective Potential of Naringin against\nAlzheimer\u2019s Disease-like Pathology: A Comprehensive Review"],"prefix":"10.2174","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-6101","authenticated-orcid":true,"given":"Ashini","family":"Singh","sequence":"first","affiliation":[{"name":"Division of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, 281406, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-5067","authenticated-orcid":true,"given":"Niraj","family":"Kumar Singh","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, 281406, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/s41591-020-0781-z","volume":"26","author":"Barth\u00e9lemy N.R.","year":"2020","unstructured":"Barth\u00e9lemy N.R.; Li Y.; Joseph-Mathurin N.; Gordon B.A.; Hassenstab J.; Benzinger T.L.S.; Buckles V.; Fagan A.M.; Perrin R.J.; Goate A.M.; Morris J.C.; Karch C.M.; Xiong C.; Allegri R.; Mendez P.C.; Berman S.B.; Ikeuchi T.; Mori H.; Shimada H.; Shoji M.; Suzuki K.; Noble J.; Farlow M.; Chhatwal J.; Graff-Radford N.R.; Salloway S.; Schofield P.R.; Masters C.L.; Martins R.N.; O\u2019Connor A.; Fox N.C.; Levin J.; Jucker M.; Gabelle A.; Lehmann S.; Sato C.; Bateman R.J.; McDade E.; A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer\u2019s disease. 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