{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:08:44Z","timestamp":1793840924008,"version":"4.6.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"10","funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["81473653"],"award-info":[{"award-number":["81473653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["81774242"],"award-info":[{"award-number":["81774242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPPS"],"published-print":{"date-parts":[[2019,9,20]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Vitamin D, as a natural medicine, is known to regulate calcium and phosphate homeostasis.\nBut abundant research has shown that vitamin D also plays a regulatory role in autoimmunity, inflammation,\nangiogenesis and vascular cell activity. Since the vitamin D receptor (VDR) is widely distributed\nin vascular endothelial cells, vascular smooth muscle cells and cardiomyocytes, the role of vitamin\nD and VDR in hypertension has received extensive attention. Hypertension is a disease with high incidence\nand high cardiovascular risk. In recent years, both clinical trials and animal experiments have\nshown that vitamin D plays a regulatory role in decreasing blood pressure (BP) through inhibiting\nrenin-angiotensin-aldosterone system activity, modulating function of vascular wall and reducing vascular\noxidative stress. A growing body of data suggest that vitamin D deficiency is associated with increased\ncardiovascular disease risk in hypertension, even short-term vitamin D deficiency may directly\nraise BP and promote target organ damage. Due to the high correlation between vitamin D and hypertension,\nvitamin D supplementation therapy may be a new insight in the treatment of hypertension. The\naim of this review will explore the mechanisms of the vitamin D and VDR in regulating the BP and\nprotecting against the target organ damage.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389203720666190807130504","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T08:25:53Z","timestamp":1565166353000},"page":"984-995","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Vitamin D and Vitamin D Receptor: New Insights in the Treatment of Hypertension"],"prefix":"10.2174","volume":"20","author":[{"given":"Lin","family":"Lin","sequence":"first","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, 250003 Ji-nan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, 250003 Ji-nan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, 250003 Ji-nan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Gai","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, 250003 Ji-nan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlun","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, 250003 Ji-nan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Protein &amp; Peptide Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/174151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T23:41:42Z","timestamp":1570232502000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/174151\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,9,20]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389203720666190807130504","relation":{},"ISSN":["1389-2037"],"issn-type":[{"value":"1389-2037","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9,20]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}