{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T20:45:40Z","timestamp":1745268340950,"version":"3.37.3"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"10","funder":[{"DOI":"10.13039\/501100002663","name":"Seed Foundation of Innovation and Creation for Graduate Students in Northwestern Polytechnical University","doi-asserted-by":"publisher","award":["ZZ2018242","ZZ2019281"],"award-info":[{"award-number":["ZZ2018242","ZZ2019281"]}],"id":[{"id":"10.13039\/501100002663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Shaanxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2018JM7050"],"award-info":[{"award-number":["2018JM7050"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["3102018jgc010"],"award-info":[{"award-number":["3102018jgc010"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009996","name":"Shaanxi Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017BSHEDZZ119"],"award-info":[{"award-number":["2017BSHEDZZ119"]}],"id":[{"id":"10.13039\/501100009996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018T111098","2017M613211"],"award-info":[{"award-number":["2018T111098","2017M613211"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Fund","doi-asserted-by":"publisher","award":["11802246"],"award-info":[{"award-number":["11802246"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFF01012104"],"award-info":[{"award-number":["2018YFF01012104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPPS"],"published-print":{"date-parts":[[2019,9,20]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Cardiovascular disease (CVD) is the biggest killer globally and atherosclerosis (AS) is the\nmajor trigger to this pathology. Abnormal cholesterol homeostasis is the starting point of AS, especially\nthe aggregation of macrophage foam cells in the intra-arterial subcutaneous region. Reverse cholesterol\ntransport (RCT) can remove excess cholesterol from macrophages and transport it to the liver for excretion,\nmaking this process vital to alleviate AS. MicroRNAs (miRNAs) are small, noncoding RNAs that\nplay critical roles in various diseases including AS, by regulating post-transcriptional gene expression.\nMany natural compounds can exert anti-atherosclerotic effects by regulating different miRNAs that are\nimplicated in RCT. Hence, targeting these miRNAs using natural functional compounds may be a safe,\nnovel, and promising strategy to prevent and treat AS. This review describes the miRNAs involved in\nRCT and the potential uses of natural compounds to target RCT-related miRNAs to modulate AS.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389203720666190827143218","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T10:49:20Z","timestamp":1566902960000},"page":"1004-1011","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reverse cholesterol transport-related miRNAs and their regulation by natural functional compounds"],"prefix":"10.2174","volume":"20","author":[{"given":"Ziyang","family":"Lian","sequence":"first","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi\u2019an, Shaanxi 710072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi\u2019an, Shaanxi 710072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuyuan","family":"Lei","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi\u2019an, Shaanxi 710072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi\u2019an, Shaanxi 710072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingsheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi\u2019an, Shaanxi 710072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi\u2019an, Shaanxi 710072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingliang","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi\u2019an, Shaanxi 710072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junling","family":"Shi","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi\u2019an, Shaanxi 710072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyan","family":"Shao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi West Road, Xi\u2019an, Shaanxi 710072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Protein &amp; Peptide Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/174475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T23:41:45Z","timestamp":1570232505000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/174475\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,9,20]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389203720666190827143218","relation":{},"ISSN":["1389-2037"],"issn-type":[{"type":"print","value":"1389-2037"}],"subject":[],"published":{"date-parts":[[2019,9,20]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}