{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:28:25Z","timestamp":1791419305761,"version":"4.3.3"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"10","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPPS"],"published-print":{"date-parts":[[2020,12,31]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>The neuroinflammatory process is associated with the pathogenesis of many\ncardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D\nseems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term lack\nof vitamin D leads to over-activation of the renin-angiotensin-aldosterone system (RAAS), one of the\nessential mechanisms of blood pressure regulation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Purpose of Review:<\/jats:title>\n<jats:p>This review summarizes the latest studies carried out to evaluate the primary\nmechanisms underlying the neuroprotective effect of vitamin D and its receptors (VDR) in the central\nnervous system. Besides, the present article condenses the evidence supporting the link between vitamin\nD and the RAAS in hypertension and neuroinflammation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Highlights Standpoints:<\/jats:title>\n<jats:p>Vitamin D deficiency is highly prevalent in the world, and the rising prevalence\nof neuroinflammatory diseases and associated pathologies such as hypertension around the world\njustifies the urgent need of searching new and more effective therapeutic methods that could be related\nto RAAS modulation and vitamin D levels management.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389203721666200606220719","type":"journal-article","created":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T19:37:37Z","timestamp":1591472257000},"page":"948-954","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Vitamin D-RAAS Connection: An Integrative Standpoint into Cardiovascular and Neuroinflammatory Disorders"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2188-977X","authenticated-orcid":true,"given":"Virna Margarita Mart\u00edn","family":"Gim\u00e9nez","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Ciencias Qu\u00edmicas, Facultad de Ciencias Qu\u00edmicas y Tecnol\u00f3gicas, Universidad Cat\u00f3lica de Cuyo, San Juan, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7159-2918","authenticated-orcid":true,"given":"Ra\u00fal Lelio","family":"Sanz","sequence":"additional","affiliation":[{"name":"\u00c1rea de Farmacolog\u00eda, Departamento de Patolog\u00eda, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5417-1276","authenticated-orcid":true,"given":"Feres Jos\u00e9 Mocayar","family":"Mar\u00f3n","sequence":"additional","affiliation":[{"name":"\u00c1rea de Farmacolog\u00eda, Departamento de Patolog\u00eda, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9899-5947","authenticated-orcid":true,"given":"Le\u00f3n","family":"Ferder","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nephrology Division, Miller School of Medicine, University of Miami, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2279-7626","authenticated-orcid":true,"given":"Walter","family":"Manucha","sequence":"additional","affiliation":[{"name":"\u00c1rea de Farmacolog\u00eda, Departamento de Patolog\u00eda, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Protein &amp; Peptide Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/182565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/182565\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/182565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T06:25:27Z","timestamp":1609482327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/182565\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,31]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,12,31]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389203721666200606220719","relation":{},"ISSN":["1389-2037"],"issn-type":[{"value":"1389-2037","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,31]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}