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Nlrp3 inflammasome, a key contributor in the pathogenesis\nof angina pectoris, requires activation and primary signaling for the commencement of inflammation.\nNlrp3 inflammasome elicits out an inflammatory response by the emission of pro-inflammatory\ncytokines by ROS (reactive oxygen species) production, mobilization of K&lt;sup&gt;+&lt;\/sup&gt; efflux and Ca&lt;sup&gt;2+&lt;\/sup&gt; and\nby activation of lysosome destabilization that eventually causes pyroptosis, a programmed cell\ndeath process. Thus, inflammasome is considered to be one of the factors involved in the progression\nof coronary artery diseases and has an intricate role in the development of angina pectoris.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389203721999201208200242","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T09:48:21Z","timestamp":1607507301000},"page":"228-236","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Understanding The Role of Inflammasome in Angina Pectoris"],"prefix":"10.2174","volume":"22","author":[{"given":"Ishita","family":"Sharma","sequence":"first","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-7708","authenticated-orcid":true,"given":"Tapan","family":"Behl","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Bungau","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine of Pharmacy, University of Oradea, Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Fatima College of Health Science, Al Ain, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Kumar","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, University Campus, Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Arora","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.12688\/f1000research.15096.1","volume":"7","author":"Saleh M.","year":"2018","unstructured":"Saleh M.; Ambrose J.A.; Understanding myocardial infarction. 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