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There have been individual\nscattered experiments trying to identify potential values of various intracellular metabolites.\nPurines and Pyrimidines, which are vital molecules governing various aspects of cellular biochemical\nreactions, have been long sought as crucial candidates for the same, but there are still many\nquestions that go unanswered. Some critical functions of these molecules associated with neuromodulation\nactivities have been identified. They are also known to play a role in foetal neurodevelopment,\nbut there is a lacuna in understanding their mechanisms. In this review, we have tried to assemble\nand identify the importance of purines and pyrimidines, connecting them with the prevalence\nof neurodegenerative diseases. The leading cause of this class of diseases is protein misfolding\nand the formation of amyloids. A direct correlation between loss of balance in cellular homeostasis\nand amyloidosis is yet an unexplored area. This review aims at bringing the current literature\navailable under one umbrella serving as a foundation for further extensive research in this field of\ndrug development in neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1389203721999201208200605","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T04:48:21Z","timestamp":1607489301000},"page":"170-189","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Purines and Pyrimidines: Metabolism, Function and Potential as Therapeutic Options in Neurodegenerative Diseases"],"prefix":"10.2174","volume":"22","author":[{"given":"Debanjan","family":"Kundu","sequence":"first","affiliation":[{"name":"School of Biochemical Engineering, Indian Institute of Technology BHU, Varanasi, UP - 221005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikash Kumar","family":"Dubey","sequence":"additional","affiliation":[{"name":"School of Biochemical Engineering, Indian Institute of Technology BHU, Varanasi, UP - 221005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.brainresbull.2019.01.031","volume":"151","author":"Sebasti\u00e1n-Serrano \u00c1.","year":"2019","unstructured":"Sebasti\u00e1n-Serrano \u00c1.; de Diego-Garc\u00eda L.; di Lauro C.; Bianchi C.; D\u00edaz-Hern\u00e1ndez M.; Nucleotides regulate the common molecular mechanisms that underlie neurodegenerative diseases; Therapeutic implications. 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