{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:38:13Z","timestamp":1792546693079,"version":"4.5.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"3","funder":[{"DOI":"10.13039\/501100010822","name":"Chengdu Bureau of Science and Technology","doi-asserted-by":"publisher","award":["2015-HM02-00042-SF"],"award-info":[{"award-number":["2015-HM02-00042-SF"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572236"],"award-info":[{"award-number":["81572236"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDT"],"published-print":{"date-parts":[[2020,2,21]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Osteoimmunology is a new subject which focuses on the communication between the immune\nand the skeletal systems. Both the immune system and bone communicate with each other. Proinflammatory\ncytokines, such as tumor necrosis factor-alpha (TNF-\u03b1) and interleukin-6 (IL-6) play\nimportant roles in immune responses and bone metabolism. TNF-\u03b1 and IL-6 enhance macrophage activation\nand antigen presentation, as well as regulating immunity through different mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>A variety of groups have reported that TNF-\u03b1 suppresses osteoblasts activity at some stages of differentiation\nand stimulates osteoclast proliferation and differentiation. In contrast, IL-6 mediates the actions\nof osteoblasts and osteoclasts through sophisticated mechanisms, which reflect dual effects. Both\nTNF-\u03b1 and IL-6 can mediate the activity of osteocytes. Furthermore, both TNF-\u03b1 and IL-6 are important\npathogenic factors related to immune-mediated bone diseases including rheumatoid arthritis and\npostmenopausal osteoporosis. This review will discuss the contradictory findings concerning TNF-\u03b1\nand IL-6 in osteoimmunology and their potential for clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1389450120666190821161259","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T12:29:33Z","timestamp":1566390573000},"page":"213-227","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["TNF-\u03b1 and IL-6: The Link between Immune and Bone System"],"prefix":"10.2174","volume":"21","author":[{"given":"Tiantian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/174389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T03:02:50Z","timestamp":1583204570000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/174389\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,21]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2,21]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389450120666190821161259","relation":{},"ISSN":["1389-4501"],"issn-type":[{"value":"1389-4501","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,21]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}