{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:13:49Z","timestamp":1760346829785,"version":"3.37.3"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"4","funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018T111085"],"award-info":[{"award-number":["2018T111085"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011710","name":"Shaanxi Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2018HJCG-08"],"award-info":[{"award-number":["2018HJCG-08"]}],"id":[{"id":"10.13039\/501100011710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008387","name":"Xi'an Science and Technology Bureau","doi-asserted-by":"publisher","award":["2017115 SF\/YX009"],"award-info":[{"award-number":["2017115 SF\/YX009"]}],"id":[{"id":"10.13039\/501100008387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDT"],"published-print":{"date-parts":[[2020,3,2]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Millions of people, especially for the aging people, are suffered by bone-loss diseases, such\nas rheumatoid arthritis (RA) and osteoporosis. Therefore, better understanding the involved mechanisms\nof bone metabolism is required for further treat on such diseases. Particularly, during the pathological\nprocess of bone losing, RANKL as a member of the tumor necrosis factor (TNF) superfamily,\ncould induce osteoclast precursor cells differentiate into mature osteoclast, which grant its essential\nrole in osteolysis. In recent years, with the increased attention paid to the natural compounds discovering\nstudies, the therapeutic application of natural plant-derivatives have been widely recognized.\nTherefore, our present study aim to summarize the current novel research progressions on RANKL\nand its downstream signaling pathways in bone cellular differentiation, and provide a further insight\nfor RANKL as the important drug targets in bone loss diseases. Besides that, in our current study, we\nalso aim to briefly introduce the current application of several natural compounds for treating\nRANKL-mediated osteoclastic activation by modulating the RANKL signaling pathway and their\ntherapeutic effects on the prevention of osteoporosis, osteoarthritis (OA) and RA.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389450120666190930145144","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T07:45:31Z","timestamp":1569829531000},"page":"344-357","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Study of Natural Compounds Targeting RANKL Signaling Pathway for the Treatment of Bone Diseases"],"prefix":"10.2174","volume":"21","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"He","sequence":"additional","affiliation":[{"name":"Department of orthopedics, Fifth Hospital of Xi'an, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of neurosurgery, Shunde Hospital of Southern Medical University, Fo Shan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baorong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingbo","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/175218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T08:45:02Z","timestamp":1583225102000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/175218\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,2]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,3,2]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389450120666190930145144","relation":{},"ISSN":["1389-4501"],"issn-type":[{"type":"print","value":"1389-4501"}],"subject":[],"published":{"date-parts":[[2020,3,2]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}