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In this entry process, a diversity of host cell proteases and androgen receptor play a\nvery important role directly or indirectly. These features of SARS-CoV-2 entry contribute to its\nrapid spread and severe symptoms, high fatality rates among infected patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>This review is based on the latest published literature including review articles, research articles,\nhypothetical manuscript, preprint articles and official documents. The literature search was made\nfrom various published papers on physiological aspects relevant to SARS-CoV and SARS-CoV-2.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>In this report, we focus on the role of host cell proteases (ACE2, ADAM17, TMPRSS2) and androgen\nreceptor (AR) in SARS-CoV-2 infection. The hypotheses put forth by us are based on the role\nplayed by the proteases ACE2, ADAM17, TMPRSS2 and AR in SARS-CoV-2 infection, which\nwere deduced based on various studies. We have also summarized how these host proteins increase\nthe pathology and the infective ability of SARS-CoV-2 and we posit that their inhibition may be a\ntherapeutic option for preventing SARS-CoV-2 infection.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389450121999201125201112","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T04:51:50Z","timestamp":1606452710000},"page":"1149-1157","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can Host Cell Proteins Like ACE2, ADAM17, TMPRSS2, Androgen Receptor be the Efficient Targets in SARS-CoV-2 Infection?"],"prefix":"10.2174","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-5511","authenticated-orcid":true,"given":"Vivek K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Biochemistry, ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra-282004,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8177-3691","authenticated-orcid":true,"given":"Madhan K.","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Immunology, ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra-282004,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shripad","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Immunology, ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra-282004,India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","volume":"395","author":"Lu R.","year":"2020","unstructured":"Lu R.; Zhao X.; Li J.; Niu P.; Yang B.; Wu H.; Wang W.; Song H.; Huang B.; Zhu N.; Bi Y.; Ma X.; Zhan F.; Wang L.; Hu T.; Zhou H.; Hu Z.; Zhou W.; Zhao L.; Chen J.; Meng Y.; Wang J.; Lin Y.; Yuan J.; Xie Z.; Ma J.; Liu W.J.; Wang D.; Xu W.; Holmes E.C.; Gao G.F.; Wu G.; Chen W.; Shi W.; Tan W.; Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. 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