{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:09:08Z","timestamp":1780330148779,"version":"3.54.1"},"reference-count":244,"publisher":"Bentham Science Publishers Ltd.","issue":"6","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDT"],"published-print":{"date-parts":[[2021,4]]},"abstract":"Alzheimer\u2019s disease is a common and most chronic neurological disorder (NDs) associated with cognitive dysfunction. Pathologically, Alzheimer\u2019s disease (AD) is characterized by the presence of &#946;-amyloid (A&#946;) plaques, hyper-phosphorylated tau proteins, and neurofibrillary tangles, however, persistence oxidative-nitrative stress, endoplasmic reticulum stress, mitochondrial dysfunction, inflammatory cytokines, pro-apoptotic proteins along with altered neurotransmitters level are common etiological attributes in its pathogenesis. Rivastigmine, memantine, galantamine, and donepezil are FDA approved drugs for symptomatic management of AD, whereas tacrine has been withdrawn because of hepatotoxic profile. These approved drugs only exert symptomatic relief and exhibit poor patient compliance. In the current scenario, the number of published evidence shows the neuroprotective potential of naturally occurring bioactive molecules via their antioxidant, anti-inflammatory, antiapoptotic and neurotransmitter modulatory properties. Despite their potent therapeutic implications, concerns have arisen in context to their efficacy and probable clinical outcome. Thus, to overcome these glitches, many heterocyclic and cyclic hydrocarbon compounds inspired by natural sources have been synthesized and showed improved therapeutic activity. Computational studies (molecular docking) have been used to predict the binding affinity of these natural bioactive as well as synthetic compounds derived from natural sources for the acetylcholine esterase, &#945;\/&#946; secretase Nuclear Factor kappa- light-chain-enhancer of activated B cells (NF-kB), Nuclear factor erythroid 2-related factor 2(Nrf2) and other neurological targets. Thus, in this review, we have discussed the molecular etiology of AD, focused on the pharmacotherapeutics of natural products, chemical and pharmacological aspects and multi-targeted designed ligands (MTDLs) of synthetic and semisynthetic molecules derived from the natural sources along with some important on-going clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1389450121999201209201004","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T04:05:44Z","timestamp":1607659544000},"page":"685-720","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Current Quest in Natural Bioactive Compounds for Alzheimer\u2019s Disease: Multi-Targeted-Designed-Ligand Based Approach with Preclinical and Clinical Based Evidence"],"prefix":"10.2174","volume":"22","author":[{"given":"Ashif","family":"Iqubal","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and Research, JamiaHamdard, New Delhi-110062,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Obaidur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Medicine, School of Pharmaceutical Education and Research, JamiaHamdard, New Delhi-110062,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musheer","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education and Research, JamiaHamdard, New Delhi-110062,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratichi","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, JamiaHamdard, New Delhi-110062,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Rafi","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, JamiaHamdard, New Delhi-110062,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Kashif","family":"Iqubal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education and Research, JamiaHamdard, New Delhi-110062,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abul Kalam","family":"Najmi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and Research, JamiaHamdard, New Delhi-110062,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheem Hyder","family":"Pottoo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal, University, P.O.BOX 1982, Damman, 31441,Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Ehtaishamul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and Research, JamiaHamdard, New Delhi-110062,India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.2174\/1871527315666161003165855","volume":"15","author":"Ahmad S.S.","year":"2016","unstructured":"Ahmad S.S.; Akhtar S.; Jamal Q.M.; Multiple targets for the management of Alzheimer\u2019s disease. 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