{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T08:52:23Z","timestamp":1772527943601,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"12","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDT"],"published-print":{"date-parts":[[2021,8,6]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>In neurodegenerative disorders, there is a progressive degeneration of the body, leading\nto the death of nerve cells. In this state, a patient gets affected day by day with mental weakness, dementia,\nand ataxia. Alzheimer\u2019s disease (AD) is the most common irreversible neurodegenerative\nbrain disorder mainly affecting people over the age of 65. Many types of research suggest that the\nmain culprit for AD is the aggregated form of a (39-43) amino acid peptide called amyloid beta.\nAmyloid beta (A\u03b2) is generated by the action of beta-secretase and gamma-secretase on the larger\nglycoprotein. Gamma (\u03b3) secretase is an intra-membrane protease complex that cleaves the single--\npass transmembrane protein, the amyloid precursor protein, and Notch. The \u03b3-secretase complex\ncontains presenilin, presenilin enhancer-2, anterior pharynx defective-1, and nicastrin. Any mutation\nin presenilin-1 or the cleavage of amyloid precursor protein by \u03b3-secretase directly or indirectly\nis associated with AD. Therefore, the prevention of this enzyme is one of the solutions for AD.\nIn this article, we discuss the \u03b3-secretase complex and its inhibitors that can contribute to the prevention\nof AD.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389450121999201230203709","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T07:53:18Z","timestamp":1609487598000},"page":"1376-1403","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Insight \u03b3-Secretase: Structure, Function, and Role in Alzheimer\u2019s Disease"],"prefix":"10.2174","volume":"22","author":[{"given":"Suvadeep","family":"Mal","sequence":"first","affiliation":[{"name":"Haldia Institute of Pharmacy, Kshudiram Nagar, Haldia-721657, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udita","family":"Malik","sequence":"additional","affiliation":[{"name":"Pirijpur-Rankini mahula, Jamalpur, Purba Burdwan-713404, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9623-1617","authenticated-orcid":true,"given":"Dilipkumar","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh-495 009, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Mishra","sequence":"additional","affiliation":[{"name":"2033 Addenbrock Drive Morrisville- NC-27560, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/189660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189660\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/189660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T19:46:20Z","timestamp":1628538380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189660\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,6]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,8,6]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389450121999201230203709","relation":{},"ISSN":["1389-4501"],"issn-type":[{"value":"1389-4501","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,6]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}