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In order to address such concerns, poor water-soluble\ndrugs are conjugated with poly(ethylene glycol) (PEG) to obtain PEGylated drugs, which\nhave improved water solubility and can also self-assemble in an aqueous solution to form micelles\n(PEGylated drug micelles). The surface PEG layer enhances the micelles\u2019 colloidal stability and reduces\nthe interaction with physiological surroundings. Meanwhile, PEGylated drug micelles are tumor-\ntargeting via the enhanced permeation and retention (EPR) effect to improve antitumor efficacy\nin comparison with free drugs. PEGylated drug micelles employ drugs as parts of the carrier\nmedium, which increases the micelles\u2019 drug loading capacity relatively. The development of stimuli-\nresponsive PEGylated drug micelles facilitates the drug release to be smart and controllable.\nMoreover, the PEGylated drug micelles show great potentials in overcoming the challenges of cancer\ntherapy, such as multidrug resistance (MDR), angiogenesis, immunosuppression, and so on. In\nthis review, we highlight the research progresses of PEGylated drug micelles, including the structures\nand properties, smart stimuli-responsive PEGylated drug micelles, and the challenges that\nhave been overcome by PEGylated drug micelles.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389450122666201231130702","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T07:56:46Z","timestamp":1609487806000},"page":"870-881","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Self-Assembled Micelles of Amphiphilic PEGylated Drugs for Cancer Treatment"],"prefix":"10.2174","volume":"22","author":[{"given":"Majdi","family":"Al-Amili","sequence":"first","affiliation":[{"name":"School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-7705","authenticated-orcid":true,"given":"Zhu","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6897-2055","authenticated-orcid":true,"given":"Shengrong","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240,China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12951-019-0510-2","volume":"17","author":"Liu J.","year":"2019","unstructured":"Liu J.; Li F.; Zheng J.; Li B.; Zhang D.; Jia L.; Redox\/NIR dual-responsive MoS for synergetic chemo-photothermal therapy of cancer. 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