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Therefore, one of the strategies to\naid the discovery of new drugs is to identify and inhibit molecular targets essential to the parasite's\nsurvival, such as the proteasome, which degrades most proteins in the parasite cells. Our study has\npresented several proteasome inhibitors with various pharmacophoric cores, and two of them, 5,\nand 13, have stood out in the clinical phase of treatment for leishmaniasis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389450124666230719104147","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T07:04:37Z","timestamp":1689836677000},"page":"781-789","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Proteasome as a Drug Target in Trypanosomatid Diseases"],"prefix":"10.2174","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-9985","authenticated-orcid":true,"given":"Mariana Luiza","family":"Silva","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese de Mol\u00e9culas Medicinais (LaSMMed), Departamento de Qu\u00edmica, Centro de Ci\u00eancias Exatas,\nUniversidade Estadual de Londrina, Londrina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6550-7820","authenticated-orcid":true,"given":"Kaio Maciel","family":"de Santiago-Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese de Mol\u00e9culas Medicinais (LaSMMed), Departamento de Qu\u00edmica, Centro de Ci\u00eancias Exatas,\nUniversidade Estadual de Londrina, Londrina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-3046","authenticated-orcid":true,"given":"Marci\u00e9li","family":"Fabris","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese de Mol\u00e9culas Medicinais (LaSMMed), Departamento de Qu\u00edmica, Centro de Ci\u00eancias Exatas,\nUniversidade Estadual de Londrina, Londrina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-2119","authenticated-orcid":true,"given":"Priscila Goes","family":"Camargo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese de Mol\u00e9culas Medicinais (LaSMMed), Departamento de Qu\u00edmica, Centro de Ci\u00eancias Exatas,\nUniversidade Estadual de Londrina, Londrina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelle","family":"de Lima Ferreira Bispo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese de Mol\u00e9culas Medicinais (LaSMMed), Departamento de Qu\u00edmica, Centro de Ci\u00eancias Exatas,\nUniversidade Estadual de Londrina, Londrina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","year":"2022","unstructured":"Leishmaniasis, World Heal. 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