{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:03:13Z","timestamp":1791223393269,"version":"4.1.0"},"reference-count":99,"publisher":"Bentham Science Publishers Ltd.","issue":"11","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MRMC"],"published-print":{"date-parts":[[2020,7,17]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Sesame (Sesamum indicum L.) seeds have been authenticated for its medicinal value in both\nChinese and Indian systems of medicine. Its numerous potential nutritional benefits are attributed to its\nmain bioactive constituents, sesamol. As a result of those studies, several molecular mechanisms are\nemerging describing the pleiotropic biological effects of sesamol. This review summarized the most\ninteresting in vitro and in vivo studies on the biological effects of sesamol. The present work summarises\ndata available from Pubmed and Scopus database. Several molecular mechanisms have been elucidated\ndescribing the pleiotropic biological effects of sesamol. Its major therapeutic effects have been\nelicited in managing oxidative and inflammatory conditions, metabolic syndrome and mood disorders.\nFurther, compelling evidence reflected the ability of sesamol in inhibiting proliferation of the inflammatory\ncell, prevention of invasion and angiogenesis via affecting multiple molecular targets and\ndownstream mechanisms. Sesamol is a safe, non\u2010toxic chemical that mediates anti\u2010inflammatory\neffects by down\u2010regulating the transcription of inflammatory markers such as cytokines, redox status,\nprotein kinases, and enzymes that promote inflammation. In addition, sesamol also induces apoptosis\nin cancer cells via mitochondrial and receptor\u2010mediated pathways, as well as activation of caspase cascades.\nIn the present review, several pharmacological effects of sesamol are summarised namely, antioxidant,\nanti-cancer, neuroprotective, cardioprotective, anti-inflammatory, hypolipidemic, radioprotective,\nanti-aging, anti-ulcer, anti-dementia, anti-depressant, antiplatelet, anticonvulsant, anti-anxiolytic,\nwound healing, cosmetic (skin whitening), anti-microbial, matrix metalloproteinase (MMPs) inhibition,\nhepatoprotective activity and other biological effects. Here we have summarized the proposed\nmechanism behind these pharmacological effects.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389557520666200313120419","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T13:45:41Z","timestamp":1584107141000},"page":"988-1000","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5185-1903","authenticated-orcid":true,"given":"Bellamkonda","family":"Bosebabu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5943-6560","authenticated-orcid":true,"given":"Sri Pragnya","family":"Cheruku","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3744-8135","authenticated-orcid":true,"given":"Mallikarjuna Rao","family":"Chamallamudi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2218-2004","authenticated-orcid":true,"given":"Madhavan","family":"Nampoothiri","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7684-1242","authenticated-orcid":true,"given":"Rekha R.","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6653-4660","authenticated-orcid":true,"given":"Krishnadas","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4878-7386","authenticated-orcid":true,"given":"Vipan K.","family":"Parihar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of California, Irvine, CA 92697- 2695, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4929-3954","authenticated-orcid":true,"given":"Nitesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"328","volume":"8","author":"Miraj S.","year":"2016","unstructured":"Miraj S.; Kiani S.; Bioactivity of Sesamum Indicum: A review study. 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