{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:38:23Z","timestamp":1790253503751,"version":"4.1.0"},"reference-count":71,"publisher":"Bentham Science Publishers Ltd.","issue":"10","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MRMC"],"published-print":{"date-parts":[[2020,5,27]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Tropical infectious diseases cause millions of deaths every year in developing countries,\nwith about half of the world population living at risk. Mayaro virus (MAYV) is an emerging arbovirus\nthat causes Mayaro fever, which is characterized by fever, headache, diarrhea, arthralgia, and rash.\nThese symptoms can be clinically indistinguishable from other arboviruses, such as Dengue, Zika, and\nChikungunya, which makes the diagnosis and treatment of the disease more difficult. Though, the Mayaro\nvirus is a potential candidate to cause large-scale epidemics on the scale of ZIKV and CHIKV.\nDespite this, there is no licensed vaccine or antiviral for the treatment of Mayaro fever and most arboviruses,\nso the design and development of candidates for antiviral drugs are urgently needed. In this\ncontext, this mini-review aims to provide an overview of studies of anti-MAYV derivatives and highlight\nthe importance of the discovery and development of promising drug candidates for Mayaro fever.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389557520666200316160425","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T13:48:00Z","timestamp":1584366480000},"page":"921-928","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antiviral Drug Discovery and Development for Mayaro Fever \u2013 What do we have so far?"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2550-5315","authenticated-orcid":true,"given":"Marcos V.P.","family":"Mello","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaisa F.S.","family":"Domingos","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davis F.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Virology, Paulo de G\u00f3es Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana M.J.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thayssa P.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos R.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra M.T.","family":"Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.bjm.2016.10.008","volume":"47","author":"Mota M.T. deO","year":"2016","unstructured":"Mota M.T. deO; Terzian A.C.; Silva M.L.C.R.; Estofolete C.; Nogueira M.L.; Mosquito-transmitted viruses - the great Brazilian challenge. 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