{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:31:07Z","timestamp":1696336267464},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"18","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MRMC"],"published-print":{"date-parts":[[2020,12,7]]},"abstract":"<jats:sec>\n<jats:title \/>\n<jats:p>The need for new therapeutics and drug delivery systems has become necessary owing to\nthe public health concern associated with the emergence of multidrug-resistant microorganisms.\nAmong the newly discovered therapeutic agents is cefiderocol, which was discovered by Shionogi\nCompany, Japan as an injectable siderophore cephalosporin. Just like the other \u03b2-lactam antibiotics,\ncefiderocol exhibits antibacterial activity via cell wall synthesis inhibition, especially in Gram negative\nbacteria (GNB); it binds to the penicillin-binding proteins, but its unique attribute is that it crosses the\nperiplasmic space of bacteria owing to its siderophore-like attribute; it also resists the activity of\n\u03b2-lactamases. Among all the synthesized compounds with the modified C-7 side chain, cefiderocol (3)\npresented the best and well-balanced activity against multi-drug resistant (MDR) Gram negative bacteria,\nincluding those that are resistant to carbapenem. \u0130n this article, an overview of the recent studies on\ncefiderocol was presented.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389557520666200818211405","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T07:29:17Z","timestamp":1597822157000},"page":"1908-1916","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Overview of the Activities of Cefiderocol Against Sensitive and Multidrug- Resistant (MDR) Bacteria"],"prefix":"10.2174","volume":"20","author":[{"given":"Manaf","family":"AlMatar","sequence":"first","affiliation":[{"name":"Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang (UMP), Gambang, 26300 Kuantan, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Albarri","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Natural and Applied Sciences (Fen Bilimleri Enstitusu) Cukurova University, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Essam A.","family":"Makky","sequence":"additional","affiliation":[{"name":"Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang (UMP), Gambang, 26300 Kuantan, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u015f\u0131l","family":"Var","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Agricultural Faculty, Cukurova University, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"K\u00f6ksal","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Mini-Reviews in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/185044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T05:15:15Z","timestamp":1607404515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/185044\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,7]]},"references-count":0,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2020,12,7]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389557520666200818211405","relation":{},"ISSN":["1389-5575"],"issn-type":[{"value":"1389-5575","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,7]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}